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MPP6 Mpp6p [ Saccharomyces cerevisiae S288C ]

Gene ID: 855758, updated on 18-Sep-2024

Summary

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Official Symbol
MPP6
Official Full Name
Mpp6p
Primary source
SGD:S000005307
Locus tag
YNR024W
See related
AllianceGenome:SGD:S000005307; FungiDB:YNR024W; VEuPathDB:YNR024W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables poly(U) RNA binding activity. Involved in exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) and nuclear RNA surveillance. Located in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (672409..672969)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene mitochondrial 54S ribosomal protein MRPL50 Neighboring gene Snf12p Neighboring gene Sar family guanine nucleotide exchange factor SEC12 Neighboring gene putative pyridoxal kinase BUD17

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structure and reconstitution of yeast Mpp6-nuclear exosome complexes reveals that Mpp6 stimulates RNA decay and recruits the Mtr4 helicase. Wasmuth EV, et al. Elife, 2017 Jul 25. PMID 28742025, Free PMC Article
  2. Substrate discrimination and quality control require each catalytic activity of TRAMP and the nuclear RNA exosome. Das M, et al. Proc Natl Acad Sci U S A, 2021 Apr 6. PMID 33782132, Free PMC Article
  3. The exosome-binding factors Rrp6 and Rrp47 form a composite surface for recruiting the Mtr4 helicase. Schuch B, et al. EMBO J, 2014 Dec 1. PMID 25319414, Free PMC Article
  4. The exosome cofactor Rrp47 is critical for the stability and normal expression of its associated exoribonuclease Rrp6 in Saccharomyces cerevisiae. Feigenbutz M, et al. PLoS One, 2013. PMID 24224060, Free PMC Article
  5. Cotranscriptional recruitment of RNA exosome cofactors Rrp47p and Mpp6p and two distinct Trf-Air-Mtr4 polyadenylation (TRAMP) complexes assists the exonuclease Rrp6p in the targeting and degradation of an aberrant messenger ribonucleoprotein particle (mRNP) in yeast. Stuparevic I, et al. J Biol Chem, 2013 Nov 1. PMID 24047896, Free PMC Article

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mpp6-exosomes can recruit Mtr4, while Mpp6 and Rrp47 each contribute to Mtr4-dependent RNA decay, with maximal Mtr4-dependent decay observed with both cofactors.
    Title: Structure and reconstitution of yeast Mpp6-nuclear exosome complexes reveals that Mpp6 stimulates RNA decay and recruits the Mtr4 helicase.
  2. Cotranscriptional recruitment of RNA exosome cofactors Rrp47p and Mpp6p and two distinct Trf-Air-Mtr4 polyadenylation (TRAMP) complexes assists the exonuclease Rrp6p in the targeting and degradation of an aberrant messenger
    Title: Cotranscriptional recruitment of RNA exosome cofactors Rrp47p and Mpp6p and two distinct Trf-Air-Mtr4 polyadenylation (TRAMP) complexes assists the exonuclease Rrp6p in the targeting and degradation of an aberrant messenger ribonucleoprotein particle (mRNP) in yeast.
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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables poly(U) RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nuclear mRNA surveillance of mRNA 3'-end processing IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in nuclear mRNA surveillance of spliceosomal pre-mRNA splicing IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in nuclear polyadenylation-dependent CUT catabolic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in nuclear polyadenylation-dependent CUT catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nuclear polyadenylation-dependent rRNA catabolic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus HDA PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Mpp6p
NP_014421.3
  • Nuclear exosome-associated RNA binding protein; involved in surveillance of pre-rRNAs and pre-mRNAs, and the degradation of cryptic non-coding RNAs (ncRNA); copurifies with ribosomes; relocalizes to the cytosol in response to hypoxia

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    672409..672969
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183201.3 → NP_014421.3  TPA: Mpp6p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014421.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W1J9, P53725
    UniProtKB/TrEMBL
    A6ZS98, B3LPL9, C7GLN3, C8ZFQ1, G2WL81, N1NWT3
    Conserved Domains (1) summary
    pfam10175
    Location:9 → 181
    MPP6; M-phase phosphoprotein 6
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53725.1

Gene LinkOut

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