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CDC14A cell division cycle 14A [ Homo sapiens (human) ]

Gene ID: 8556, updated on 13-Feb-2019

Summary

Official Symbol
CDC14Aprovided by HGNC
Official Full Name
cell division cycle 14Aprovided by HGNC
Primary source
HGNC:HGNC:1718
See related
Ensembl:ENSG00000079335 MIM:603504
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
cdc14; DFNB32; DFNB35; hCDC14; DFNB105
Summary
The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. It is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, suggesting a role in cell cycle control. This protein has been shown to interact with, and dephosphorylate tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splicing of this gene results in several transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Expression
Broad expression in testis (RPKM 5.6), bone marrow (RPKM 3.3) and 24 other tissues See more
Orthologs

Genomic context

See CDC14A in Genome Data Viewer
Location:
1p21.2
Exon count:
24
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (100345001..100520281)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (100810598..100985833)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene RNA 3'-terminal phosphate cyclase Neighboring gene microRNA 553 Neighboring gene chromosome 5 open reading frame 15 pseudogene Neighboring gene uncharacterized LOC105379827 Neighboring gene BCAS2 pseudogene 2 Neighboring gene G protein-coupled receptor 88 Neighboring gene HNF4 motif-containing MPRA enhancer 127

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • APC/C-mediated degradation of cell cycle proteins, organism-specific biosystem (from REACTOME)
    APC/C-mediated degradation of cell cycle proteins, organism-specific biosystemThe Anaphase Promoting Complex or Cyclosome (APC/C) functions during mitosis to promote sister chromatid separation and mitotic exit through the degradation of mitotic cyclins and securin. This compl...
  • Cell Cycle, organism-specific biosystem (from WikiPathways)
    Cell Cycle, organism-specific biosystemThe cell cycle is the series of events that takes place in a cell leading to its division and duplication (replication). Regulation of the cell cycle involves processes crucial to the survival of a c...
  • Cell Cycle, organism-specific biosystem (from REACTOME)
    Cell Cycle, organism-specific biosystem
    Cell Cycle
  • Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
    Cell Cycle, Mitotic, organism-specific biosystemThe replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried o...
  • Cell cycle, organism-specific biosystem (from KEGG)
    Cell cycle, organism-specific biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
  • Cell cycle, conserved biosystem (from KEGG)
    Cell cycle, conserved biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
  • Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase, organism-specific biosystem (from REACTOME)
    Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase, organism-specific biosystemThe activity of the APC/C must be appropriately regulated during the cell cycle to ensure the timely degradation of its substrates. Of particular importance is the conversion from APC/C:Cdc20 to APC...
  • MAPK family signaling cascades, organism-specific biosystem (from REACTOME)
    MAPK family signaling cascades, organism-specific biosystemThe mitogen activated protein kinases (MAPKs) are a family of conserved protein serine threonine kinases that respond to varied extracellular stimuli to activate intracellular processes including gen...
  • MAPK6/MAPK4 signaling, organism-specific biosystem (from REACTOME)
    MAPK6/MAPK4 signaling, organism-specific biosystemMAPK6 and MAPK4 (also known as ERK3 and ERK4) are vertebrate-specific atypical MAP kinases. Atypical MAPK are less well characterized than their conventional counterparts, and are generally classifi...
  • Regulation of mitotic cell cycle, organism-specific biosystem (from REACTOME)
    Regulation of mitotic cell cycle, organism-specific biosystem
    Regulation of mitotic cell cycle
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
phosphoprotein phosphatase activity TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine phosphatase activity TAS
Traceable Author Statement
more info
 
protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein tyrosine/serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cell division IEA
Inferred from Electronic Annotation
more info
 
cell proliferation TAS
Traceable Author Statement
more info
PubMed 
microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitotic cell cycle arrest IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidyl-tyrosine dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of exit from mitosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sensory perception of sound IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
centrosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
kinociliary basal body ISS
Inferred from Sequence or Structural Similarity
more info
 
kinocilium ISS
Inferred from Sequence or Structural Similarity
more info
 
mitotic spindle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear body IDA
Inferred from Direct Assay
more info
 
nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus TAS
Traceable Author Statement
more info
PubMed 
spindle pole IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
stereocilium tip ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
dual specificity protein phosphatase CDC14A
Names
CDC10 (cell division cycle 10, S. cerevisiae, homolog)
CDC14 cell division cycle 14 homolog A
NP_001306139.1
NP_001306140.1
NP_001306141.1
NP_003663.2
NP_201569.1
NP_201570.1
XP_005271351.1
XP_005271353.1
XP_011540642.1
XP_011540643.1
XP_011540647.1
XP_016858135.1
XP_016858136.1
XP_024306271.1
XP_024306272.1
XP_024306273.1
XP_024306274.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051602.1 RefSeqGene

    Range
    12453..159451
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001319210.1NP_001306139.1  dual specificity protein phosphatase CDC14A isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 3' UTR and coding sequence compared to variant 2. The resulting isoform (4) has a shorter and distinct C-terminus compared to isoform 2.
    Source sequence(s)
    AC104457, AF000367, AL589990, DA461435, DQ530256
    Consensus CDS
    CCDS86000.1
    UniProtKB/Swiss-Prot
    Q9UNH5
    Related
    ENSP00000496374.1, ENST00000644813.1
    Conserved Domains (3) summary
    COG2453
    Location:175329
    CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]
    pfam14671
    Location:17152
    DSPn; Dual specificity protein phosphatase, N-terminal half
    cl21483
    Location:187326
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  2. NM_001319211.1NP_001306140.1  dual specificity protein phosphatase CDC14A isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence compared to variant 2. The resulting isoform (5) is shorter at the N-terminus compared to isoform 2.
    Source sequence(s)
    AA929031, AF064102, AK302310, DB029799
    Consensus CDS
    CCDS81353.1
    UniProtKB/Swiss-Prot
    Q9UNH5
    UniProtKB/TrEMBL
    A0A0U1RQX7, B4DY86
    Related
    ENSP00000489217.1, ENST00000635056.2
    Conserved Domains (4) summary
    COG2453
    Location:117271
    CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]
    pfam14671
    Location:194
    DSPn; Dual specificity protein phosphatase, N-terminal half
    pfam15279
    Location:355555
    SOBP; Sine oculis-binding protein
    cl21483
    Location:129268
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  3. NM_001319212.1NP_001306141.1  dual specificity protein phosphatase CDC14A isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks an alternate exon compared to variant 2. The resulting isoform (6) is shorter at the C-terminus compared to isoform 2.
    Source sequence(s)
    AA929031, AC104457, AL589990, BC038979, DA461435
    UniProtKB/Swiss-Prot
    Q9UNH5
  4. NM_003672.4NP_003663.2  dual specificity protein phosphatase CDC14A isoform 1

    See identical proteins and their annotated locations for NP_003663.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 3' UTR and coding sequence compared to variant 2. The resulting isoform (1) has a shorter and distinct C-terminus compared to isoform 2.
    Source sequence(s)
    AC104457, AL589990
    Consensus CDS
    CCDS769.1
    UniProtKB/Swiss-Prot
    Q9UNH5
    UniProtKB/TrEMBL
    Q59EF4
    Related
    ENSP00000336739.3, ENST00000336454.4
    Conserved Domains (3) summary
    COG2453
    Location:175329
    CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]
    pfam14671
    Location:17152
    DSPn; Dual specificity protein phosphatase, N-terminal half
    cl21483
    Location:187326
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  5. NM_033312.2NP_201569.1  dual specificity protein phosphatase CDC14A isoform 2

    See identical proteins and their annotated locations for NP_201569.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) encodes the longest isoform (2).
    Source sequence(s)
    AA929031, AF122013, BC038979, DA461435, DA885382
    Consensus CDS
    CCDS770.1
    UniProtKB/Swiss-Prot
    Q9UNH5
    Related
    ENSP00000354916.6, ENST00000361544.11
    Conserved Domains (4) summary
    COG2453
    Location:175329
    CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]
    pfam14671
    Location:17152
    DSPn; Dual specificity protein phosphatase, N-terminal half
    pfam15279
    Location:413613
    SOBP; Sine oculis-binding protein
    cl21483
    Location:187326
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  6. NM_033313.2NP_201570.1  dual specificity protein phosphatase CDC14A isoform 3

    See identical proteins and their annotated locations for NP_201570.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence compared to variant 2. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 2.
    Source sequence(s)
    AF064103, AF122013, AL589990, BU609013, CB156695, DA461435, DA885382
    Consensus CDS
    CCDS771.1
    UniProtKB/Swiss-Prot
    Q9UNH5
    Related
    ENSP00000359142.3, ENST00000370124.8
    Conserved Domains (2) summary
    pfam14671
    Location:16152
    DSPn; Dual specificity protein phosphatase, N-terminal half
    cl21483
    Location:187326
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    100345001..100520281
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024450503.1XP_024306271.1  dual specificity protein phosphatase CDC14A isoform X5

    Related
    ENSP00000495617.1, ENST00000647005.1
    Conserved Domains (2) summary
    pfam14671
    Location:194
    DSPn; Dual specificity protein phosphatase, N-terminal half
    cl21483
    Location:129268
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  2. XM_024450504.1XP_024306272.1  dual specificity protein phosphatase CDC14A isoform X9

  3. XM_017002646.1XP_016858135.1  dual specificity protein phosphatase CDC14A isoform X7

  4. XM_005271294.3XP_005271351.1  dual specificity protein phosphatase CDC14A isoform X1

    Related
    ENSP00000494661.1, ENST00000644676.1
    Conserved Domains (4) summary
    COG2453
    Location:176330
    CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]
    pfam14671
    Location:18153
    DSPn; Dual specificity protein phosphatase, N-terminal half
    pfam15279
    Location:414614
    SOBP; Sine oculis-binding protein
    cl21483
    Location:188327
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  5. XM_011542340.2XP_011540642.1  dual specificity protein phosphatase CDC14A isoform X3

    Conserved Domains (3) summary
    COG2453
    Location:176330
    CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]
    pfam14671
    Location:18153
    DSPn; Dual specificity protein phosphatase, N-terminal half
    cl21483
    Location:188327
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  6. XM_005271296.3XP_005271353.1  dual specificity protein phosphatase CDC14A isoform X4

    Conserved Domains (3) summary
    COG2453
    Location:176330
    CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]
    pfam14671
    Location:18153
    DSPn; Dual specificity protein phosphatase, N-terminal half
    cl21483
    Location:188327
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  7. XM_017002647.1XP_016858136.1  dual specificity protein phosphatase CDC14A isoform X8

  8. XM_011542341.3XP_011540643.1  dual specificity protein phosphatase CDC14A isoform X2

    Conserved Domains (4) summary
    COG2453
    Location:163317
    CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]
    pfam14671
    Location:35140
    DSPn; Dual specificity protein phosphatase, N-terminal half
    pfam15279
    Location:413601
    SOBP; Sine oculis-binding protein
    cl21483
    Location:175314
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  9. XM_024450505.1XP_024306273.1  dual specificity protein phosphatase CDC14A isoform X9

  10. XM_011542345.3XP_011540647.1  dual specificity protein phosphatase CDC14A isoform X6

    Conserved Domains (4) summary
    COG2453
    Location:47201
    CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]
    pfam14671
    Location:324
    DSPn; Dual specificity protein phosphatase, N-terminal half
    pfam15279
    Location:297485
    SOBP; Sine oculis-binding protein
    cl21483
    Location:59198
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  11. XM_024450506.1XP_024306274.1  dual specificity protein phosphatase CDC14A isoform X9

RNA

  1. XR_002957888.1 RNA Sequence

  2. XR_002957887.1 RNA Sequence

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