CDC14A cell division cycle 14A [Homo sapiens (human)] - Gene

Summary

Official Symbol: CDC14Aprovided by HGNC
Official Full Name: cell division cycle 14Aprovided by HGNC
Primary source: HGNC:HGNC:1718
See related: Ensembl:ENSG00000079335 MIM:603504; AllianceGenome:HGNC:1718
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: cdc14; DFNB32; DFNB35; hCDC14; DFNB105
Summary: The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. It is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, suggesting a role in cell cycle control. This protein has been shown to interact with, and dephosphorylate tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splicing of this gene results in several transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Expression: Broad expression in testis (RPKM 5.6), bone marrow (RPKM 3.3) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1p21.2

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (100345001..100520277)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (100192980..100368314)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (100810557..100985833)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

UNC5B mediates G2/M phase arrest of bladder cancer cells by binding to CDC14A and P53.
Title: UNC5B mediates G2/M phase arrest of bladder cancer cells by binding to CDC14A and P53.
Human cells lacking CDC14A and CDC14B show differences in ciliogenesis but not in mitotic progression.
Title: Human cells lacking CDC14A and CDC14B show differences in ciliogenesis but not in mitotic progression.
The phosphorylation of hCDC14A modulated by ZIPK regulates autophagy of murine pancreatic islet beta-TC3 cells upon glucose stimulation.
Title: The phosphorylation of hCDC14A modulated by ZIPK regulates autophagy of murine pancreatic islet β-TC3 cells upon glucose stimulation.
When transcripts matter: delineating between non-syndromic hearing loss DFNB32 and hearing impairment infertile male syndrome (HIIMS).
Title: When transcripts matter: delineating between non-syndromic hearing loss DFNB32 and hearing impairment infertile male syndrome (HIIMS).
The study functionally characterizes two variants and provides further confirmatory evidence that CDC14A is associated with a rare form of hereditary hearing loss.
Title: Novel Loss-of-Function Variants in CDC14A are Associated with Recessive Sensorineural Hearing Loss in Iranian and Pakistani Patients.
Point to differences in Cdk1-mediated mechanisms of regulation between human and yeast Cdc14 orthologues.
Title: Biochemical analyses reveal amino acid residues critical for cell cycle-dependent phosphorylation of human Cdc14A phosphatase by cyclin-dependent kinase 1.
we show that drebrin and hCDC14A regulate the recruitment of the actin organizer Arp2 to centrosomes. In addition, during ciliogenesis hCDC14A also regulates endocytosis and targeting of myosin Va vesicles to the basal body in a drebrin-independent manner, indicating that it impacts primary cilia formation in a multilayered manner.
Title: The human phosphatase CDC14A modulates primary cilium length by regulating centrosomal actin nucleation.
CDC14A activity is necessary for hearing and male fertility.
Title: CDC14A phosphatase is essential for hearing and male fertility in mouse and human.
Reduction in the levels of hCDC14A and eplin mRNA is frequently associated with colorectal carcinoma and is correlated with poor prognosis. Authors therefore propose that eplin dephosphorylation by hCDC14A reduces actin dynamics to restrict tumor malignancy.
Title: Human phosphatase CDC14A regulates actin organization through dephosphorylation of epithelial protein lost in neoplasm.
Mutations in CDC14A gene are associated with Autosomal-Recessive Severe to Profound Deafness.
Title: Mutations in CDC14A, Encoding a Protein Phosphatase Involved in Hair Cell Ciliogenesis, Cause Autosomal-Recessive Severe to Profound Deafness.

Submit: New GeneRIF Correction See all GeneRIFs (31)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Autosomal recessive nonsyndromic hearing loss 32 MedGen: C1837608 OMIM: 608653 GeneReviews: Not available	Compare labs

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-143777 (e-PCR)
- UniSTS:172042

SHGC-75230 (e-PCR)
- UniSTS:58647

A008M41 (e-PCR)
- UniSTS:46408

SHGC-145140 (e-PCR)
- UniSTS:174413

CDC14A_422 (e-PCR)
- UniSTS:277080

NoName (e-PCR)
- UniSTS:483673

RH92716 (e-PCR)
- UniSTS:90747

AL009775 (e-PCR)
- UniSTS:77471

RH119509 (e-PCR)
- UniSTS:133550

AFMa109wh5 (e-PCR)
- UniSTS:25338

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables myosin phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine/threonine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine phosphatase activity	TAS Traceable Author Statement more info
enables protein tyrosine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in cilium assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cytokinesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein dephosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of exit from mitosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in sensory perception of sound	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info
located_in kinociliary basal body	ISS Inferred from Sequence or Structural Similarity more info
located_in kinocilium	ISS Inferred from Sequence or Structural Similarity more info
is_active_in mitotic spindle	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear body	IDA Inferred from Direct Assay more info
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in spindle pole	IBA Inferred from Biological aspect of Ancestor more info
located_in stereocilium tip	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: dual specificity protein phosphatase CDC14A

Names: CDC10 (cell division cycle 10, S. cerevisiae, homolog); CDC14 cell division cycle 14 homolog A

NP_001306139.1

EC 3.1.3.16

EC 3.1.3.48

NP_001306140.1

EC 3.1.3.16

EC 3.1.3.48

NP_001306141.1

EC 3.1.3.16

EC 3.1.3.48

NP_003663.2

EC 3.1.3.16

EC 3.1.3.48

NP_201569.1

EC 3.1.3.16

EC 3.1.3.48

NP_201570.1

EC 3.1.3.16

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_051602.2 RefSeqGene

Range

12506..180277

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_1418

mRNA and Protein(s)

NM_001319210.2 → NP_001306139.1 dual specificity protein phosphatase CDC14A isoform 4

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 3' UTR and coding sequence compared to variant 2. The resulting isoform (4) has a shorter and distinct C-terminus compared to isoform 2.

Source sequence(s)

AC104457, AL589990

Consensus CDS

CCDS86000.1

UniProtKB/TrEMBL

A0A2R8Y6L0

Related

ENSP00000496374.1, ENST00000644813.1

Conserved Domains (3) summary

COG2453
Location:175 → 329

CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]

pfam14671
Location:17 → 152

DSPn; Dual specificity protein phosphatase, N-terminal half

cl21483
Location:187 → 326

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
NM_001319211.2 → NP_001306140.1 dual specificity protein phosphatase CDC14A isoform 5

Status: REVIEWED

Description

Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence compared to variant 2. The resulting isoform (5) is shorter at the N-terminus compared to isoform 2.

Source sequence(s)

AA929031, AC104457, AF064102, AK302310, DB029799

Consensus CDS

CCDS81353.1

UniProtKB/TrEMBL

A0A0U1RQX7, B4DY86

Related

ENSP00000489217.1, ENST00000635056.2

Conserved Domains (4) summary

COG2453
Location:117 → 271

CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]

pfam14671
Location:1 → 94

DSPn; Dual specificity protein phosphatase, N-terminal half

pfam15279
Location:355 → 555

SOBP; Sine oculis-binding protein

cl21483
Location:129 → 268

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
NM_001319212.2 → NP_001306141.1 dual specificity protein phosphatase CDC14A isoform 6

Status: REVIEWED

Description

Transcript Variant: This variant (6) lacks an alternate exon compared to variant 2. The resulting isoform (6) is shorter at the C-terminus compared to isoform 2.

Source sequence(s)

AC104457, AL589990

UniProtKB/Swiss-Prot

Q9UNH5
NM_003672.4 → NP_003663.2 dual specificity protein phosphatase CDC14A isoform 1

See identical proteins and their annotated locations for NP_003663.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) differs in the 3' UTR and coding sequence compared to variant 2. The resulting isoform (1) has a shorter and distinct C-terminus compared to isoform 2.

Source sequence(s)

AC104457, AL589990

Consensus CDS

CCDS769.1

UniProtKB/Swiss-Prot

A6MA65, B1AQ14, B1AQ15, O43171, O60727, O60728, Q52LH9, Q8IXX0, Q9UNH5

UniProtKB/TrEMBL

Q59EF4

Related

ENSP00000336739.3, ENST00000336454.5

Conserved Domains (3) summary

COG2453
Location:175 → 329

CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]

pfam14671
Location:17 → 152

DSPn; Dual specificity protein phosphatase, N-terminal half

cl21483
Location:187 → 326

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
NM_033312.3 → NP_201569.1 dual specificity protein phosphatase CDC14A isoform 2

See identical proteins and their annotated locations for NP_201569.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) encodes the longest isoform (2).

Source sequence(s)

AC104457, AL589990

Consensus CDS

CCDS770.1

UniProtKB/TrEMBL

A0A2R8YDJ8

Related

ENSP00000354916.6, ENST00000361544.11

Conserved Domains (4) summary

COG2453
Location:175 → 329

CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]

pfam14671
Location:17 → 152

DSPn; Dual specificity protein phosphatase, N-terminal half

pfam15279
Location:413 → 613

SOBP; Sine oculis-binding protein

cl21483
Location:187 → 326

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
NM_033313.3 → NP_201570.1 dual specificity protein phosphatase CDC14A isoform 3

See identical proteins and their annotated locations for NP_201570.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence compared to variant 2. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 2.

Source sequence(s)

AC104457, AL589990

Consensus CDS

CCDS771.1

UniProtKB/TrEMBL

A0A2R8YEK7

Related

ENSP00000359142.3, ENST00000370124.8

Conserved Domains (2) summary

pfam14671
Location:16 → 152

DSPn; Dual specificity protein phosphatase, N-terminal half

cl21483
Location:187 → 326

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...