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RPS19B [ Saccharomyces cerevisiae S288C ]

Gene ID: 855414, updated on 22-Aug-2024

Summary

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Official Symbol
RPS19B
Primary source
FungiDB:YNL302C
Locus tag
YNL302C
See related
SGD:S000005246; AllianceGenome:SGD:S000005246; VEuPathDB:YNL302C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
RP55B
Summary
A structural constituent of ribosome. Involved in rRNA export from nucleus and ribosomal small subunit biogenesis. Part of cytosolic small ribosomal subunit. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia and Diamond-Blackfan anemia 1. Orthologous to human RPS19 (ribosomal protein S19). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XIV
Exon count:
2
Sequence:
Chromosome: XIV; NC_001146.8 (61958..62943, complement)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Bxi1p Neighboring gene Rab family GTPase YPT11 Neighboring gene ribosomal 60S subunit protein L18B Neighboring gene Tos6p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The role of promoter elements of a ribosomal protein gene in Saccharomyces cerevisiae under various physiological conditions. Papciak SM, et al. Mol Gen Genet, 1992 Jul. PMID 1495481
  2. Genetic evidence for 18S rRNA binding and an Rps19p assembly function of yeast nucleolar protein Nep1p. Buchhaupt M, et al. Mol Genet Genomics, 2006 Sep. PMID 16721597
  3. Molecular basis of Diamond-Blackfan anemia: structure and function analysis of RPS19. Gregory LA, et al. Nucleic Acids Res, 2007. PMID 17726054, Free PMC Article
  4. Genetic mapping of two pairs of linked ribosomal protein genes in Saccharomyces cerevisiae. Papciak SM, et al. Curr Genet, 1987. PMID 3329973
  5. Association of RAP1 binding sites with stringent control of ribosomal protein gene transcription in Saccharomyces cerevisiae. Moehle CM, et al. Mol Cell Biol, 1991 May. PMID 2017175, Free PMC Article

See all (76) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
enables structural constituent of ribosome IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in ribosomal small subunit assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ribosomal small subunit biogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in ribosomal small subunit biogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ribosomal subunit export from nucleus IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in ribosomal subunit export from nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of cytosolic small ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytosolic small ribosomal subunit IDA
Inferred from Direct Assay
more info
 PubMed 
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
located_in ribosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ribosomal 40S subunit protein S19B
NP_014097.1
  • Protein component of the small (40S) ribosomal subunit; required for assembly and maturation of pre-40 S particles; homologous to mammalian ribosomal protein S19, no bacterial homolog; mutations in human RPS19 are associated with Diamond Blackfan anemia; RPS19B has a paralog, RPS19A, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    61958..62943 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183140.1 → NP_014097.1  TPA: ribosomal 40S subunit protein S19B [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014097.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W0P2, P07281
    UniProtKB/TrEMBL
    A6ZSH7, D3UFA5, G2WLG6, N1NY24
    Conserved Domains (1) summary
    pfam01090
    Location:5 → 142
    Ribosomal_S19e; Ribosomal protein S19e
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P07281.2

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