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SCJ1 Scj1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 855254, updated on 18-Sep-2024

Summary

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Official Symbol
SCJ1
Official Full Name
Scj1p
Primary source
SGD:S000004827
Locus tag
YMR214W
See related
AllianceGenome:SGD:S000004827; FungiDB:YMR214W; VEuPathDB:YMR214W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables chaperone binding activity. Involved in protein folding in endoplasmic reticulum; response to unfolded protein; and ubiquitin-dependent ERAD pathway. Located in endoplasmic reticulum lumen. Human ortholog(s) of this gene implicated in polycystic kidney disease. Orthologous to human DNAJB11 (DnaJ heat shock protein family (Hsp40) member B11). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (695350..696483)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Efr3p Neighboring gene Cef1p Neighboring gene putative 1,3-beta-glucanosyltransferase Neighboring gene serine/threonine protein kinase SKY1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Analysis of ER resident proteins in Saccharomyces cerevisiae: implementation of H/KDEL retrieval sequences. Young CL, et al. Traffic, 2013 Apr. PMID 23324027, Free PMC Article
  2. A homologue of the bacterial heat-shock gene DnaJ that alters protein sorting in yeast. Blumberg H, et al. Nature, 1991 Feb 14. PMID 2000136
  3. The yeast JEM1p is a DnaJ-like protein of the endoplasmic reticulum membrane required for nuclear fusion. Nishikawa S, et al. J Biol Chem, 1997 May 16. PMID 9148890
  4. Cer1p, a novel Hsp70-related protein required for posttranslational endoplasmic reticulum translocation in yeast. Hamilton TG, et al. J Biol Chem, 1996 Nov 29. PMID 8940034
  5. Distinct classes of misfolded proteins differentially affect the growth of yeast compromised for proteasome function. Burns GD, et al. FEBS Lett, 2021 Sep. PMID 34358326, Free PMC Article

See all (79) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables Hsp70 protein binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein-folding chaperone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-folding chaperone binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables unfolded protein binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in ERAD pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein folding IEA
Inferred from Electronic Annotation
more info
  
involved_in protein folding in endoplasmic reticulum IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in response to unfolded protein IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum HDA PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum lumen IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum lumen IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Scj1p
NP_013941.2
  • One of several homologs of bacterial chaperone DnaJ; located in the ER lumen where it cooperates with Kar2p to mediate maturation of proteins

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    695350..696483
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182721.1 → NP_013941.2  TPA: Scj1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013941.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W039, P25303
    UniProtKB/TrEMBL
    A6ZMS6, B3LMA2, B5VPY1, C7GRD7, C8ZF78, G2WKS1, N1P0I9
    Conserved Domains (1) summary
    COG0484
    Location:21 → 377
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P25303.2

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