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SPC2 signal peptidase complex subunit SPC2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854949, updated on 19-Nov-2025
Official Symbol
SPC2
Official Full Name
signal peptidase complex subunit SPC2
Primary source
SGD:S000004519
Locus tag
YML055W
See related
AllianceGenome:SGD:S000004519; FungiDB:YML055W; VEuPathDB:YML055W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
SPY1
Summary
Contributes to peptidase activity. Involved in negative regulation of post-translational protein targeting to membrane, translocation; protein targeting to ER; and signal peptide processing. Located in endoplasmic reticulum. Part of signal peptidase complex. Orthologous to human SPCS2 (signal peptidase complex subunit 2). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See SPC2 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (164790..165326)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene calcineurin catalytic subunit A Neighboring gene IMP dehydrogenase IMD4 Neighboring gene ncRNA Neighboring gene L-lactate dehydrogenase (cytochrome) Neighboring gene uncharacterized protein

Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Elucidation of Ubiquitin-Related Functions via an Ubiquitin Overexpression Approach. Masuda R, et al. Cells, 2024 Dec 5. PMID 39682759, Free PMC Article
  2. Yeast signal peptidase contains a glycoprotein and the Sec11 gene product. YaDeau JT, et al. Proc Natl Acad Sci U S A, 1991 Jan 15. PMID 1846444, Free PMC Article
  3. Structurally related Spc1p and Spc2p of yeast signal peptidase complex are functionally distinct. Mullins C, et al. J Biol Chem, 1996 Nov 15. PMID 8910564
  4. In addition to SEC11, a newly identified gene, SPC3, is essential for signal peptidase activity in the yeast endoplasmic reticulum. Fang H, et al. J Biol Chem, 1997 May 16. PMID 9148930
  5. The yeast SPC22/23 homolog Spc3p is essential for signal peptidase activity. Meyer HA, et al. J Biol Chem, 1997 May 16. PMID 9148931

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
contributes_to peptidase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of post-translational protein targeting to membrane, translocation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein targeting to ER IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein targeting to ER IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein targeting to ER IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein targeting to ER IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in signal peptide processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal peptide processing IEA
Inferred from Electronic Annotation
more info
  
involved_in signal peptide processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal peptide processing NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum HDA PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane NAS
Non-traceable Author Statement
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of signal peptidase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of signal peptidase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of signal peptidase complex IEA
Inferred from Electronic Annotation
more info
  
part_of signal peptidase complex IPI
Inferred from Physical Interaction
more info
 PubMed 
Preferred Names
signal peptidase complex subunit SPC2
NP_013657.1
  • Subunit of signal peptidase complex; complex catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; inhibits SRP-independent translocation into the ER with STE24; homologous to mammalian SPC25; other members of the complex are Spc1p, Spc1p, and Sec11p

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    164790..165326
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182413.1 → NP_013657.1  TPA: signal peptidase complex subunit SPC2

    See identical proteins and their annotated locations for NP_013657.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VZB9, Q04969
    UniProtKB/TrEMBL
    A0A0L8VK16, A6ZM11, B3LLK1, B5VP75, C7GME8, C8ZEF2, G2WK01, N1P686
    Conserved Domains (1) summary
    pfam06703
    Location:20 → 170
    SPC25; Microsomal signal peptidase 25 kDa subunit (SPC25)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q04969.1

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