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ERG13 hydroxymethylglutaryl-CoA synthase [ Saccharomyces cerevisiae S288C ]

Gene ID: 854913, updated on 17-May-2024

Summary

Gene symbol
ERG13
Gene description
hydroxymethylglutaryl-CoA synthase
Primary source
FungiDB:YML126C
Locus tag
YML126C
See related
SGD:S000004595; AllianceGenome:SGD:S000004595; VEuPathDB:YML126C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
HMGS
Summary
Enables hydroxymethylglutaryl-CoA synthase activity. Involved in ergosterol biosynthetic process. Located in nucleus. Orthologous to human HMGCS1 (3-hydroxy-3-methylglutaryl-CoA synthase 1) and HMGCS2 (3-hydroxy-3-methylglutaryl-CoA synthase 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See ERG13 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (19060..20535, complement)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Msc1p Neighboring gene Rsc9p Neighboring gene cytochrome-b5 reductase Neighboring gene alpha-tubulin TUB3 Neighboring gene ncRNA

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
hydroxymethylglutaryl-CoA synthase
NP_013580.1
  • 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase; catalyzes the formation of HMG-CoA from acetyl-CoA and acetoacetyl-CoA; involved in the second step in mevalonate biosynthesis

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    19060..20535 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182489.1NP_013580.1  TPA: hydroxymethylglutaryl-CoA synthase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013580.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W0F9, P54839
    UniProtKB/TrEMBL
    A0A6A5PRN9, A6ZLT9, B3LLD4, C7GVA7, C8ZE76, G2WJT1, N1NXW8
    Conserved Domains (1) summary
    TIGR01833
    Location:45490
    HMG-CoA-S_euk; 3-hydroxy-3-methylglutaryl-CoA-synthase, eukaryotic clade