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ATP18 F1F0 ATP synthase subunit i [ Saccharomyces cerevisiae S288C ]

Gene ID: 854893, updated on 5-Jul-2025
Official Symbol
ATP18
Official Full Name
F1F0 ATP synthase subunit i
Primary source
SGD:S000007247
Locus tag
YML081C-A
See related
AllianceGenome:SGD:S000007247; FungiDB:YML081C-A; VEuPathDB:YML081C-A
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Contributes to proton-transporting ATP synthase activity, rotational mechanism. Involved in mitochondrial proton-transporting ATP synthase complex assembly and proton motive force-driven ATP synthesis. Located in mitochondrion. Part of proton-transporting ATP synthase complex. [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
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See ATP18 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (103983..104162, complement)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene putative cystathionine gamma-synthase Neighboring gene Tda9p Neighboring gene tRNA dihydrouridine synthase

Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Isolation of supernumerary yeast ATP synthase subunits e and i. Characterization of subunit i and disruption of its structural gene ATP18. Vaillier J, et al. J Biol Chem, 1999 Jan 1. PMID 9867878
  2. F1F0-ATP synthase complex interactions in vivo can occur in the absence of the dimer specific subunit e. Gavin PD, et al. J Bioenerg Biomembr, 2005 Apr. PMID 15906150
  3. Roles of the lipid-binding motifs of Atg18 and Atg21 in the cytoplasm to vacuole targeting pathway and autophagy. Nair U, et al. J Biol Chem, 2010 Apr 9. PMID 20154084, Free PMC Article
  4. The peripheral stalk participates in the yeast ATP synthase dimerization independently of e and g subunits. Fronzes R, et al. Biochemistry, 2006 May 30. PMID 16716082
  5. Stepwise assembly of dimeric F(1)F(o)-ATP synthase in mitochondria involves the small F(o)-subunits k and i. Wagner K, et al. Mol Biol Cell, 2010 May 1. PMID 20219971, Free PMC Article

See all (49) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that Su k (Atp19) and Su i (Atp18) are involved in the assembly of Su e (Atp21) and Su g (Atp20) F(1)F(o)-ATP synthase dimers and oligomers.
    Title: Stepwise assembly of dimeric F(1)F(o)-ATP synthase in mitochondria involves the small F(o)-subunits k and i.
  2. lipid-binding motifs of Atg18 and Atg21 have roles in the cytoplasm to vacuole targeting pathway and autophagy
    Title: Roles of the lipid-binding motifs of Atg18 and Atg21 in the cytoplasm to vacuole targeting pathway and autophagy.
  3. Membrane complexes form stable associations such that dimers can be retrieved from detergent lysates of mitochondria.
    Title: F1F0-ATP synthase complex interactions in vivo can occur in the absence of the dimer specific subunit e.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables proton transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to proton-transporting ATP synthase activity, rotational mechanism IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to proton-transporting ATP synthase activity, rotational mechanism IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to proton-transporting ATP synthase activity, rotational mechanism IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in ATP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial proton-transporting ATP synthase complex assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in protein-containing complex assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proton motive force-driven ATP synthesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proton motive force-driven ATP synthesis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in proton motive force-driven ATP synthesis IEA
Inferred from Electronic Annotation
more info
  
involved_in proton motive force-driven ATP synthesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
part_of proton-transporting ATP synthase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of proton-transporting ATP synthase complex IEA
Inferred from Electronic Annotation
more info
  
part_of proton-transporting ATP synthase complex IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Preferred Names
F1F0 ATP synthase subunit i
NP_013629.1
  • Subunit of the mitochondrial F1F0 ATP synthase; F1F0 ATP synthase is a large, evolutionarily conserved enzyme complex required for ATP synthesis; termed subunit I or subunit j; does not correspond to known ATP synthase subunits in other organisms

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    103983..104162 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184340.1 → NP_013629.1  TPA: F1F0 ATP synthase subunit i

    See identical proteins and their annotated locations for NP_013629.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W0K1, P81450
    UniProtKB/TrEMBL
    A0ABF7PIS7, A6ZLY3, B3LLH4, C7GW17, C8ZEC3, G2WJX3, N1NXV6
    Conserved Domains (1) summary
    pfam04911
    Location:4 → 54
    ATP-synt_J; ATP synthase j chain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P81450.1

Gene LinkOut

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