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TSL1 trehalose 6-phosphate synthase/phosphatase complex subunit [ Saccharomyces cerevisiae S288C ]

Gene ID: 854872, updated on 17-May-2024

Summary

Gene symbol
TSL1
Gene description
trehalose 6-phosphate synthase/phosphatase complex subunit
Primary source
FungiDB:YML100W
Locus tag
YML100W
See related
SGD:S000004566; AllianceGenome:SGD:S000004566; VEuPathDB:YML100W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables enzyme regulator activity. Contributes to alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity and trehalose-phosphatase activity. Involved in trehalose biosynthetic process. Located in cytoplasm. Part of alpha,alpha-trehalose-phosphate synthase complex (UDP-forming). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See TSL1 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (70624..73920)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Cue4p Neighboring gene Arg81p Neighboring gene Taf13p

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables enzyme regulator activity IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to trehalose-phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in trehalose biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in trehalose biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in trehalose biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in trehalose metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in trehalose metabolism in response to stress IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
trehalose 6-phosphate synthase/phosphatase complex subunit
NP_013608.1
  • Large subunit of trehalose 6-phosphate synthase/phosphatase complex; Tps1p-Tps2p complex converts uridine-5'-diphosphoglucose and glucose 6-phosphate to trehalose; contributes to survival to acute lethal heat stress; mutant has aneuploidy tolerance; protein abundance increases in response to DNA replication stress; TSL1 has a paralog, TPS3, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    70624..73920
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182460.1NP_013608.1  TPA: trehalose 6-phosphate synthase/phosphatase complex subunit [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013608.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W0I5, P38427
    UniProtKB/TrEMBL
    G2WJV7
    Conserved Domains (2) summary
    COG1877
    Location:7981095
    OtsB; Trehalose-6-phosphatase [Carbohydrate transport and metabolism]
    pfam00982
    Location:317798
    Glyco_transf_20; Glycosyltransferase family 20