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FCN3 ficolin 3 [ Homo sapiens (human) ]

Gene ID: 8547, updated on 8-Dec-2018

Summary

Official Symbol
FCN3provided by HGNC
Official Full Name
ficolin 3provided by HGNC
Primary source
HGNC:HGNC:3625
See related
Ensembl:ENSG00000142748 MIM:604973
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FCNH; HAKA1
Summary
Ficolins are a group of proteins which consist of a collagen-like domain and a fibrinogen-like domain. In human serum, there are two types of ficolins, both of which have lectin activity. The protein encoded by this gene is a thermolabile beta-2-macroglycoprotein found in all human serum and is a member of the ficolin/opsonin p35 lectin family. The protein, which was initially identified based on its reactivity with sera from patients with systemic lupus erythematosus, has been shown to have a calcium-independent lectin activity. The protein can activate the complement pathway in association with MASPs and sMAP, thereby aiding in host defense through the activation of the lectin pathway. Alternative splicing occurs at this locus and two variants, each encoding a distinct isoform, have been identified. [provided by RefSeq, Jul 2008]
Expression
Biased expression in lung (RPKM 93.2), liver (RPKM 47.7) and 3 other tissues See more
Orthologs

Genomic context

See FCN3 in Genome Data Viewer
Location:
1p36.11
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (27369110..27374852, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (27695601..27701315, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene synaptotagmin like 1 Neighboring gene mitogen-activated protein kinase kinase kinase 6 Neighboring gene CD164 molecule like 2 Neighboring gene G protein-coupled receptor 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Complement cascade, organism-specific biosystem (from REACTOME)
    Complement cascade, organism-specific biosystemIn the complement cascade, a panel of soluble molecules rapidly and effectively senses a danger or damage and triggers reactions to provide a response that discriminates among foreign intruders, cell...
  • Creation of C4 and C2 activators, organism-specific biosystem (from REACTOME)
    Creation of C4 and C2 activators, organism-specific biosystemTwo pathways lead to a complex capable of activating C4 and C2.The classical pathway is triggered by activation of the C1-complex, which consists of hexameric molecule C1q and a tetramer comprising t...
  • Ficolins bind to repetitive carbohydrate structures on the target cell surface, organism-specific biosystem (from REACTOME)
    Ficolins bind to repetitive carbohydrate structures on the target cell surface, organism-specific biosystemFicolins are recognition molecules in the lectin pathway of complement activation. Three types of ficolin have been identified in humans: M-ficolin (ficolin-1, FCN1), L-ficolin (ficolin-2, FCN2) and ...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Initial triggering of complement, organism-specific biosystem (from REACTOME)
    Initial triggering of complement, organism-specific biosystemComplement activation is due to a cascade of proteolytic steps, performed by serine protease domains in some of the components. Three different pathways of activation are distinguished triggered by t...
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
  • Lectin pathway of complement activation, organism-specific biosystem (from REACTOME)
    Lectin pathway of complement activation, organism-specific biosystemActivation of the lectin pathway (LP) is initiated by Mannose-binding lectin (MBL), the hetero-complex CL-LK formed from COLEC11 (Collectin liver 1, CL-L1) and COLEC10 (Collectin kidney 1, CL-K1), an...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC22543

Gene Ontology Provided by GOA

Function Evidence Code Pubs
antigen binding IDA
Inferred from Direct Assay
more info
PubMed 
carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
serine-type endopeptidase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
complement activation IDA
Inferred from Direct Assay
more info
PubMed 
complement activation TAS
Traceable Author Statement
more info
 
complement activation, lectin pathway IDA
Inferred from Direct Assay
more info
PubMed 
complement activation, lectin pathway TAS
Traceable Author Statement
more info
 
defense response to virus IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of RNA biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of viral entry into host cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
proteolysis IEA
Inferred from Electronic Annotation
more info
 
recognition of apoptotic cell IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
blood microparticle HDA PubMed 
collagen trimer IEA
Inferred from Electronic Annotation
more info
 
extracellular region NAS
Non-traceable Author Statement
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
ficolin-3
Names
H-ficolin
collagen/fibrinogen domain-containing lectin 3 p35
collagen/fibrinogen domain-containing protein 3
ficolin (collagen/fibrinogen domain containing) 3 (Hakata antigen)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016279.1 RefSeqGene

    Range
    5001..10715
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_171

mRNA and Protein(s)

  1. NM_003665.3NP_003656.2  ficolin-3 isoform 1 precursor

    See identical proteins and their annotated locations for NP_003656.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AY358081, BG546674, CR456808
    Consensus CDS
    CCDS300.1
    UniProtKB/Swiss-Prot
    O75636
    UniProtKB/TrEMBL
    Q6UY50
    Related
    ENSP00000270879.4, ENST00000270879.8
    Conserved Domains (1) summary
    cd00087
    Location:90299
    FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
  2. NM_173452.2NP_775628.1  ficolin-3 isoform 2 precursor

    See identical proteins and their annotated locations for NP_775628.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1, resulting in a shorter protein (isoform 2) that lacks an internal segment compared to isoform 1.
    Source sequence(s)
    AY358081, BC020731, BG546674
    Consensus CDS
    CCDS301.1
    UniProtKB/Swiss-Prot
    O75636
    UniProtKB/TrEMBL
    Q6UXM4, Q6UY50
    Related
    ENSP00000347077.2, ENST00000354982.2
    Conserved Domains (1) summary
    cd00087
    Location:77288
    FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    27369110..27374852 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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