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LEO1 Leo1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 854290, updated on 17-May-2024

Summary

Gene symbol
LEO1
Gene description
Leo1p
Primary source
FungiDB:YOR123C
Locus tag
YOR123C
See related
SGD:S000005649; AllianceGenome:SGD:S000005649; VEuPathDB:YOR123C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables several functions, including RNA polymerase II C-terminal domain phosphoserine binding activity; RNA polymerase II-specific DNA-binding transcription factor binding activity; and transcription coregulator activity. Involved in several processes, including histone H3-K4 trimethylation; positive regulation of DNA-templated transcription, elongation; and transcription, DNA-templated. Located in nucleus. Part of Cdc73/Paf1 complex. Orthologous to human LEO1 (LEO1 homolog, Paf1/RNA polymerase II complex component). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See LEO1 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (553176..554570, complement)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene glycerol 2-dehydrogenase (NADP(+)) GCY1 Neighboring gene profilin Neighboring gene ubiquitin-specific protease UBP2 Neighboring gene putative monooxygenase CAT5

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Component Evidence Code Pubs
part_of Cdc73/Paf1 complex IEA
Inferred from Electronic Annotation
more info
 
part_of Cdc73/Paf1 complex IPI
Inferred from Physical Interaction
more info
PubMed 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
Leo1p
NP_014766.1
  • Component of the Paf1 complex; which associates with RNA polymerase II and is involved in histone methylation; plays a role in regulating Ty1 transposition; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    553176..554570 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183542.1NP_014766.1  TPA: Leo1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014766.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W2I1, P38439
    UniProtKB/TrEMBL
    A0A8H4BUW0, A6ZNX0, B3LJG5, C8ZI85, N1NVS8
    Conserved Domains (1) summary
    pfam04004
    Location:169335
    Leo1; Leo1-like protein