HST3 NAD-dependent histone deacetylase HST3 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: HST3
Official Full Name: NAD-dependent histone deacetylase HST3
Primary source: SGD:S000005551
Locus tag: YOR025W
See related: AllianceGenome:SGD:S000005551; FungiDB:YOR025W; VEuPathDB:YOR025W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables NAD-dependent histone deacetylase activity. Involved in several processes, including histone deacetylation; nucleic acid metabolic process; and subtelomeric heterochromatin assembly. Predicted to be located in chromosome, telomeric region and cytoplasm. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:: chromosome: XV

Exon count:: 1

Sequence:: Chromosome: XV; NC_001147.6 (378219..379562)

Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Amazing Acrobat: Yeast's Histone H3K56 Juggles Several Important Roles While Maintaining Perfect Balance.
Title: The Amazing Acrobat: Yeast's Histone H3K56 Juggles Several Important Roles While Maintaining Perfect Balance.
A novel role for Dun1 in the regulation of origin firing upon hyper-acetylation of H3K56.
Title: A novel role for Dun1 in the regulation of origin firing upon hyper-acetylation of H3K56.
This pathway is functionally relevant to TORC1 signaling since the stress sensitivity of a nonessential TORC1 mutant (tco89Delta) to hydroxyurea and arsenic can be reversed by combining tco89Delta with either hst3Delta, hst4Delta, or sit4Delta Surprisingly, while hst3Delta or hst4Delta rescues the sensitivity tco89Delta has to low concentrations of the TORC1 inhibitor rapamycin, sit4Delta fails to do so
Title: Saccharomyces cerevisiae TORC1 Controls Histone Acetylation by Signaling Through the Sit4/PP6 Phosphatase to Regulate Sirtuin Deacetylase Nuclear Accumulation.
an intricate coordination between Hst3 synthesis, genome-wide H3K56 deacetylation by Hst3, and cell cycle-regulated degradation of Hst3 by cyclin-dependent kinases and SCF(Cdc4).
Title: Regulation of the histone deacetylase Hst3 by cyclin-dependent kinases and the ubiquitin ligase SCFCdc4.
Our results suggest that Hst3 and Hst4 regulate replicative lifespan through their ability to deacetylate histone H3-K56 to minimize genomic instability.
Title: Hst3 and Hst4 histone deacetylases regulate replicative lifespan by preventing genome instability in Saccharomyces cerevisiae.
HST3 HST4 play critical roles in maintaining the hypoacetylated state of lysine56 on histone H3 within silent chromatin.
Title: HST3/HST4-dependent deacetylation of lysine 56 of histone H3 in silent chromatin.
cells lacking Hst3p in which H3 K56 is constitutively hyperacetylated, exhibit hallmarks of spontaneous DNA damage
Title: Histone H3 K56 hyperacetylation perturbs replisomes and causes DNA damage.
Hst3 Is regulated by Mec1-dependent proteolysis and controls the S phase checkpoint and sister chromatid cohesion by deacetylating histone H3 at lysine 56
Title: Hst3 is regulated by Mec1-dependent proteolysis and controls the S phase checkpoint and sister chromatid cohesion by deacetylating histone H3 at lysine 56.
That acetylation of Histone H3 by Hst3 takes place during checkpoint regulation was determined.
Title: Cell cycle and checkpoint regulation of histone H3 K56 acetylation by Hst3 and Hst4.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables NAD+ binding	IBA Inferred from Biological aspect of Ancestor more info
enables NAD+ binding	IEA Inferred from Electronic Annotation more info
enables NAD-dependent histone deacetylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables NAD-dependent histone deacetylase activity	IDA Inferred from Direct Assay more info	PubMed
enables NAD-dependent histone deacetylase activity	IEA Inferred from Electronic Annotation more info
enables NAD-dependent histone deacetylase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables NAD-dependent protein lysine deacetylase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in heterochromatin formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in heterochromatin formation	IEA Inferred from Electronic Annotation more info
involved_in mRNA transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in replication-born double-strand break repair via sister chromatid exchange	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in short-chain fatty acid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in subtelomeric heterochromatin formation	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in chromosome, telomeric region	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IC Inferred by Curator more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: NAD-dependent histone deacetylase HST3

NP_014668.1

EC 2.3.1.286

Sirtuin, histone H3 deacetylase; involved along with Hst4p in telomeric silencing, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism; member of the Sir2 family of NAD(+)-dependent protein deacetylases

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001147.6 Reference assembly

Range

378219..379562

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183444.1 → NP_014668.1 TPA: NAD-dependent histone deacetylase HST3 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014668.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W291, P53687, Q66R16

UniProtKB/TrEMBL

B5VRS7, G2WMQ6

Conserved Domains (1) summary

COG0846
Location:42 → 349

SIR2; NAD-dependent protein deacetylase, SIR2 family [Posttranslational modification, protein turnover, chaperones]