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HST3 NAD-dependent histone deacetylase HST3 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854190, updated on 7-Oct-2018

Summary

Gene symbol
HST3
Gene description
NAD-dependent histone deacetylase HST3
Primary source
SGD:S000005551
Locus tag
YOR025W
Gene type
protein coding
RNA name
NAD-dependent histone deacetylase HST3
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces

Genomic context

See HST3 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (378219..379562)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene putative carboxylic ester hydrolase Neighboring gene Ahc1p Neighboring gene Bub3p Neighboring gene Hsp90 cochaperone STI1

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GO

Function Evidence Code Pubs
NAD+ binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NAD+ binding IEA
Inferred from Electronic Annotation
more info
 
NAD-dependent histone deacetylase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NAD-dependent histone deacetylase activity IDA
Inferred from Direct Assay
more info
PubMed 
NAD-dependent histone deacetylase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
chromatin silencing at telomere IGI
Inferred from Genetic Interaction
more info
PubMed 
histone deacetylation IGI
Inferred from Genetic Interaction
more info
PubMed 
histone deacetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
replication-born double-strand break repair via sister chromatid exchange IMP
Inferred from Mutant Phenotype
more info
PubMed 
short-chain fatty acid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
chromosome, telomeric region IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleus IC
Inferred by Curator
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
NAD-dependent histone deacetylase HST3
NP_014668.1
  • Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst4p in telomeric silencing, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    378219..379562
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183444.1NP_014668.1  TPA: NAD-dependent histone deacetylase HST3 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014668.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P53687
    Conserved Domains (1) summary
    COG0846
    Location:42349
    SIR2; NAD-dependent protein deacetylase, SIR2 family [Posttranslational modification, protein turnover, chaperones]
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