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SLC22A16 solute carrier family 22 member 16 [ Homo sapiens (human) ]

Gene ID: 85413, updated on 23-Nov-2021

Summary

Official Symbol
SLC22A16provided by HGNC
Official Full Name
solute carrier family 22 member 16provided by HGNC
Primary source
HGNC:HGNC:20302
See related
Ensembl:ENSG00000004809 MIM:608276
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT2; OAT6; OCT6; OKB1; FLIPT2; HEL-S-18; dJ261K5.1
Summary
This gene encodes a member of the organic zwitterion transporter protein family which transports carnitine. The encoded protein has also been shown to transport anticancer drugs like bleomycin (PMID: 20037140) successful treatment has been correlated with the level of activity of this transporter in tumor cells. [provided by RefSeq, Dec 2011]
Expression
Biased expression in testis (RPKM 7.7) and bone marrow (RPKM 4.9) See more
Orthologs
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Genomic context

See SLC22A16 in Genome Data Viewer
Location:
6q21; 6q21-q22.1
Exon count:
12
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (110424587..110476674, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (110745890..110797816, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene D-aspartate oxidase Neighboring gene uncharacterized LOC105377936 Neighboring gene RNA, 7SL, cytoplasmic 617, pseudogene Neighboring gene uncharacterized LOC105377938 Neighboring gene uncharacterized LOC105377940 Neighboring gene uncharacterized LOC105377939

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in acid secretion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in amine transport IEA
Inferred from Electronic Annotation
more info
 
involved_in carnitine transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within carnitine transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in carnitine transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in flagellated sperm motility IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in organic cation transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within organic cation transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in organic cation transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in single fertilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in integral component of membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IC
Inferred by Curator
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
solute carrier family 22 member 16
Names
WUGSC:RG331P03.1
carnitine transporter 2
epididymis secretory protein Li 18
flipt 2
fly-like putative organic ion transporter 2
fly-like putative transporter 2
organic cation transporter 6
organic cation transporter OKB1
organic cation/carnitine transporter 6
solute carrier family 22 (organic cation transporter), member 16
solute carrier family 22 (organic cation/carnitine transporter), member 16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_033125.4NP_149116.2  solute carrier family 22 member 16

    See identical proteins and their annotated locations for NP_149116.2

    Status: VALIDATED

    Source sequence(s)
    AI632467, BC047565
    Consensus CDS
    CCDS5084.1
    UniProtKB/Swiss-Prot
    Q86VW1
    UniProtKB/TrEMBL
    A0A0K0K1K9
    Related
    ENSP00000357915.3, ENST00000368919.8
    Conserved Domains (1) summary
    cl26863
    Location:14535
    Sugar_tr; Sugar (and other) transporter

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    110424587..110476674 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011536205.2XP_011534507.1  solute carrier family 22 member 16 isoform X2

    UniProtKB/Swiss-Prot
    Q86VW1
    Related
    ENSP00000395642.1, ENST00000451557.5
    Conserved Domains (2) summary
    cd06174
    Location:128494
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00898
    Location:14506
    2A0119; cation transport protein
  2. XM_011536208.3XP_011534510.1  solute carrier family 22 member 16 isoform X5

    Conserved Domains (1) summary
    cd06174
    Location:49395
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
  3. XM_011536211.2XP_011534513.1  solute carrier family 22 member 16 isoform X8

    Conserved Domains (1) summary
    cd06174
    Location:193365
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
  4. XM_011536206.2XP_011534508.1  solute carrier family 22 member 16 isoform X3

    Conserved Domains (1) summary
    cd06174
    Location:81431
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
  5. XM_011536209.3XP_011534511.1  solute carrier family 22 member 16 isoform X6

    Conserved Domains (1) summary
    cd06174
    Location:44390
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
  6. XM_011536204.3XP_011534506.1  solute carrier family 22 member 16 isoform X1

    See identical proteins and their annotated locations for XP_011534506.1

    Conserved Domains (2) summary
    cd06174
    Location:85482
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00898
    Location:1492
    2A0119; cation transport protein
  7. XM_011536207.3XP_011534509.1  solute carrier family 22 member 16 isoform X4

    Conserved Domains (1) summary
    cd06174
    Location:61407
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
  8. XM_005267184.4XP_005267241.1  solute carrier family 22 member 16 isoform X9

    Conserved Domains (1) summary
    cd06174
    Location:9355
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
  9. XM_011536212.2XP_011534514.1  solute carrier family 22 member 16 isoform X10

    Conserved Domains (1) summary
    cd06174
    Location:123295
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
  10. XM_011536210.1XP_011534512.1  solute carrier family 22 member 16 isoform X7

    Related
    ENSP00000416310.1, ENST00000437378.5
    Conserved Domains (2) summary
    cd06174
    Location:128288
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00898
    Location:14393
    2A0119; cation transport protein
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