Format

Send to:

Choose Destination

HST1 histone deacetylase HST1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854086, updated on 9-Sep-2018

Summary

Gene symbol
HST1
Gene description
histone deacetylase HST1
Primary source
SGD:S000005429
Locus tag
YOL068C
Gene type
protein coding
RNA name
histone deacetylase HST1
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces

Genomic context

See HST1 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (200368..201879, complement)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Nba1p Neighboring gene kinetochore-associated Ndc80 complex subunit NUF2 Neighboring gene Rtg1p Neighboring gene bifunctional DRAP deaminase/tRNA pseudouridine synthase RIB2

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GO

Function Evidence Code Pubs
NAD+ binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NAD+ binding IEA
Inferred from Electronic Annotation
more info
 
NAD-dependent histone deacetylase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NAD-dependent histone deacetylase activity IDA
Inferred from Direct Assay
more info
PubMed 
NAD-dependent histone deacetylase activity (H3-K14 specific) IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NAD-dependent histone deacetylase activity (H3-K9 specific) IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NAD-independent histone deacetylase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NAD-independent histone deacetylase activity IDA
Inferred from Direct Assay
more info
PubMed 
histone deacetylase activity (H4-K16 specific) IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to nucleosome binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
chromatin organization IEA
Inferred from Electronic Annotation
more info
 
chromatin silencing at silent mating-type cassette IGI
Inferred from Genetic Interaction
more info
PubMed 
chromatin silencing at silent mating-type cassette IMP
Inferred from Mutant Phenotype
more info
PubMed 
histone H3 deacetylation IEA
Inferred from Electronic Annotation
more info
 
histone H3-K9 deacetylation IEA
Inferred from Electronic Annotation
more info
 
histone H3-K9 modification IEA
Inferred from Electronic Annotation
more info
 
histone H4 deacetylation IEA
Inferred from Electronic Annotation
more info
 
histone deacetylation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of mitotic recombination IMP
Inferred from Mutant Phenotype
more info
PubMed 
sporulation resulting in formation of a cellular spore IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Set3 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Set3 complex IDA
Inferred from Direct Assay
more info
PubMed 
chromatin silencing complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear chromatin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear heterochromatin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear pericentric heterochromatin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear telomeric heterochromatin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
histone deacetylase HST1
NP_014573.1
  • NAD(+)-dependent histone deacetylase; essential subunit of the Sum1p/Rfm1p/Hst1p complex required for ORC-dependent silencing and meiotic repression; non-essential subunit of the Set3C deacetylase complex; involved in telomere maintenance; HST1 has a paralog, SIR2, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    200368..201879 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183323.1NP_014573.1  TPA: histone deacetylase HST1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014573.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P53685
    Conserved Domains (2) summary
    cd01408
    Location:201461
    SIRT1; SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 ...
    pfam04574
    Location:53207
    DUF592; Protein of unknown function (DUF592)
Support Center