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HST1 histone deacetylase HST1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854086, updated on 18-Jan-2023

Summary

Gene symbol
HST1
Gene description
histone deacetylase HST1
Primary source
SGD:S000005429
Locus tag
YOL068C
See related
AllianceGenome:SGD:S000005429
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables NAD-dependent histone deacetylase activity and NAD-independent histone deacetylase activity. Involved in histone deacetylation; negative regulation of mitotic recombination; and silent mating-type cassette heterochromatin assembly. Part of Set3 complex. Human ortholog(s) of this gene implicated in Huntington's disease. Orthologous to human SIRT1 (sirtuin 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See HST1 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (200368..201879, complement)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Nba1p Neighboring gene kinetochore-associated Ndc80 complex subunit NUF2 Neighboring gene Rtg1p Neighboring gene bifunctional DRAP deaminase/tRNA pseudouridine synthase RIB2

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables NAD+ binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables NAD+ binding IEA
Inferred from Electronic Annotation
more info
 
enables NAD-dependent histone H4K16 deacetylase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables NAD-dependent histone deacetylase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables NAD-dependent histone deacetylase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein lysine deacetylase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
Component Evidence Code Pubs
part_of Set3 complex IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
histone deacetylase HST1
NP_014573.1
  • NAD(+)-dependent histone deacetylase; essential subunit of the Sum1p/Rfm1p/Hst1p complex required for ORC-dependent silencing and meiotic repression; non-essential subunit of the Set3C deacetylase complex; involved in telomere maintenance; HST1 has a paralog, SIR2, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    200368..201879 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183323.1NP_014573.1  TPA: histone deacetylase HST1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014573.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W1Z9, P53685
    UniProtKB/TrEMBL
    A0A8H4BWL9, A6ZNE2, C7GK35, G2WMG6, N1P426
    Conserved Domains (2) summary
    cd01408
    Location:201461
    SIRT1; Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins ...
    pfam04574
    Location:53207
    DUF592; Protein of unknown function (DUF592)