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TRZ1 tRNase Z [ Saccharomyces cerevisiae S288C ]

Gene ID: 853954, updated on 18-Sep-2024

Summary

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Official Symbol
TRZ1
Official Full Name
tRNase Z
Primary source
SGD:S000001787
Locus tag
YKR079C
See related
AllianceGenome:SGD:S000001787; FungiDB:YKR079C; VEuPathDB:YKR079C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables 3'-tRNA processing endoribonuclease activity. Involved in mitochondrial tRNA 3'-end processing and tRNA 3'-trailer cleavage, endonucleolytic. Located in mitochondrion and nucleus. Used to study infantile hypertrophic cardiomyopathy and mitochondrial complex I deficiency. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 17. Orthologous to human ELAC2 (elaC ribonuclease Z 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (586789..589305, complement)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene Msa2p Neighboring gene sorting nexin family protein Neighboring gene methylenetetrahydrofolate dehydrogenase (NAD(+)) Neighboring gene rRNA-binding ribosome biosynthesis protein RPF2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The crystal structure of Trz1, the long form RNase Z from yeast. Ma M, et al. Nucleic Acids Res, 2017 Jun 2. PMID 28379452, Free PMC Article
  2. Metal requirements and phosphodiesterase activity of tRNase Z enzymes. Späth B, et al. Biochemistry, 2007 Dec 25. PMID 18052196
  3. ELAC2 mutations cause a mitochondrial RNA processing defect associated with hypertrophic cardiomyopathy. Haack TB, et al. Am J Hum Genet, 2013 Aug 8. PMID 23849775, Free PMC Article
  4. Retrograde nuclear import of tRNA precursors is required for modified base biogenesis in yeast. Ohira T, et al. Proc Natl Acad Sci U S A, 2011 Jun 28. PMID 21670254, Free PMC Article
  5. Unstructured RNA is a substrate for tRNase Z. Shibata HS, et al. Biochemistry, 2006 May 2. PMID 16634630

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The 3.1 A crystal structure of the long-form Trz1 from Saccharomyces cerevisiae shows Trz1 is organized into 2 beta-lactamase domains connected by a long linker. The N-terminal domain has lost its catalytic residues, but keeps the long flexible arm important for tRNA binding, but it is the opposite in the C-terminal domain. Trz1 likely evolved from a duplication and fusion of the gene for the monomeric short form RNase Z.
    Title: The crystal structure of Trz1, the long form RNase Z from yeast.
  2. The yeast tRNA 3' endonuclease tRNase Z, Trz1, is catalyzing endonucleolytic tRNA 3' processing.
    Title: tRNA 3' processing in yeast involves tRNase Z, Rex1, and Rrp6.
  3. The findings reveal that 3' end processing is a limiting step for defective tRNA maturation and demonstrate that overexpression of scTRZ1 can promote defective tRNA 3' processing in vivo.
    Title: Functional conservation of tRNase ZL among Saccharomyces cerevisiae, Schizosaccharomyces pombe and humans.
  4. AthTRZ1 shows a high affinity for Zn2+ ions
    Title: Metal requirements and phosphodiesterase activity of tRNase Z enzymes.
  5. In this work, we show that the yeast homolog of ELAC2, encoded by TRZ1 (tRNase Z 1), is involved genetically in RNA processing.
    Title: Characterization of TRZ1, a yeast homolog of the human candidate prostate cancer susceptibility gene ELAC2 encoding tRNase Z.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables 3'-tRNA processing endoribonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3'-tRNA processing endoribonuclease activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 3'-tRNA processing endoribonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables endonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in mitochondrial tRNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial tRNA 3'-end processing IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mitochondrial tRNA 3'-end processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in tRNA 3'-end processing IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in tRNA 3'-end processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in tRNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus HDA PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
tRNase Z
NP_013005.1
  • tRNA 3'-end processing endonuclease tRNase Z; also localized to mitochondria and interacts genetically with Rex2 exonuclease; homolog of the human candidate prostate cancer susceptibility gene ELAC2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    586789..589305 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179869.1 → NP_013005.1  TPA: tRNase Z [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013005.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VXD9, P36159
    UniProtKB/TrEMBL
    A7A038, C7GXD1
    Conserved Domains (3) summary
    cd07718
    Location:468 → 723
    RNaseZ_ELAC1_ELAC2-C-term-like_MBL-fold; Ribonuclease Z ELAC1, C-terminus of ELAC2, and related proteins; MBL-fold metallo-hydrolase domain
    pfam13691
    Location:6 → 68
    Lactamase_B_4; tRNase Z endonuclease
    cl00716
    Location:145 → 250
    tRNA_deacylase; D-aminoacyl-tRNA deacylase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P36159.1

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