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SAP190 Sap190p [ Saccharomyces cerevisiae S288C ]

Gene ID: 853899, updated on 18-Sep-2024

Summary

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Official Symbol
SAP190
Official Full Name
Sap190p
Primary source
SGD:S000001736
Locus tag
YKR028W
See related
AllianceGenome:SGD:S000001736; FungiDB:YKR028W; VEuPathDB:YKR028W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable protein phosphatase regulator activity. Involved in several processes, including G1/S transition of mitotic cell cycle; TOR signaling; and tRNA wobble uridine modification. Predicted to be located in cytoplasm. Predicted to be active in cytosol and nucleus. Orthologous to human PPP6R1 (protein phosphatase 6 regulatory subunit 1); PPP6R2 (protein phosphatase 6 regulatory subunit 2); and PPP6R3 (protein phosphatase 6 regulatory subunit 3). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (494257..497358)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene tRNA-Arg Neighboring gene Bch2p Neighboring gene histone-binding protein SET3 Neighboring gene Gmh1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sit4p protein phosphatase is required for sensitivity of Saccharomyces cerevisiae to Kluyveromyces lactis zymocin. Jablonowski D, et al. Genetics, 2001 Dec. PMID 11779790, Free PMC Article
  2. The sensitivity of yeast mutants to oleic acid implicates the peroxisome and other processes in membrane function. Lockshon D, et al. Genetics, 2007 Jan. PMID 17151231, Free PMC Article
  3. TOR controls transcriptional and translational programs via Sap-Sit4 protein phosphatase signaling effectors. Rohde JR, et al. Mol Cell Biol, 2004 Oct. PMID 15367655, Free PMC Article
  4. Identification of phosphatase 2A-like Sit4-mediated signalling and ubiquitin-dependent protein sorting as modulators of caffeine sensitivity in S. cerevisiae. Hood-DeGrenier JK. Yeast, 2011 Mar. PMID 21360731
  5. The yeast elongator histone acetylase requires Sit4-dependent dephosphorylation for toxin-target capacity. Jablonowski D, et al. Mol Biol Cell, 2004 Mar. PMID 14718557, Free PMC Article

See all (64) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables protein phosphatase binding IEA
Inferred from Electronic Annotation
more info
  
enables protein phosphatase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in G1/S transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in TOR signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tRNA wobble uridine modification IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Sap190p
NP_012953.2
  • Protein that forms a complex with the Sit4p protein phosphatase; required for Sit4p function; member of a family of similar proteins including Sap4p, Sap155p, and Sap185p; SAP190 has a paralog, SAP185, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    494257..497358
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179818.2 → NP_012953.2  TPA: Sap190p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012953.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B5VMH6, D6VX93, P36123
    UniProtKB/TrEMBL
    N1NZG5
    Conserved Domains (1) summary
    pfam04499
    Location:266 → 762
    SAPS; SIT4 phosphatase-associated protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P36123.2

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