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URA1 dihydroorotate dehydrogenase [ Saccharomyces cerevisiae S288C ]

Gene ID: 853664, updated on 17-May-2024

Summary

Gene symbol
URA1
Gene description
dihydroorotate dehydrogenase
Primary source
FungiDB:YKL216W
Locus tag
YKL216W
See related
SGD:S000001699; AllianceGenome:SGD:S000001699
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables dihydroorotate dehydrogenase activity. Involved in 'de novo' pyrimidine nucleobase biosynthetic process. Located in cytoplasm. Is extrinsic component of membrane. Human ortholog(s) of this gene implicated in postaxial acrofacial dysostosis. Orthologous to human DHODH (dihydroorotate dehydrogenase (quinone)). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (25215..26159)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene threo-3-hydroxy-L-aspartate ammonia-lyase SRY1 Neighboring gene monocarboxylate/H+ symporter Neighboring gene 5-oxoprolinase Neighboring gene Yra2p

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables dihydroorotate dehydrogenase (fumarate) activity IEA
Inferred from Electronic Annotation
more info
 
enables dihydroorotate dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables dihydroorotate dehydrogenase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables dihydroorotate dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
 
enables dihydroorotate dehydrogenase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
dihydroorotate dehydrogenase
NP_012706.1
  • Dihydroorotate dehydrogenase; catalyzes the fourth enzymatic step in the de novo biosynthesis of pyrimidines, converting dihydroorotic acid into orotic acid

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    25215..26159
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179781.1NP_012706.1  TPA: dihydroorotate dehydrogenase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012706.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VWY7, P28272, Q2XN75, Q70DC7
    UniProtKB/TrEMBL
    A0A8H4BXQ1, B5VLU9, C7GIZ7, G2WHH8, N1NZQ4
    Conserved Domains (1) summary
    PRK02506
    Location:4314
    PRK02506; dihydroorotate dehydrogenase 1A; Reviewed