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ABCC11 ATP binding cassette subfamily C member 11 [ Homo sapiens (human) ]

Gene ID: 85320, updated on 23-May-2018
Official Symbol
ABCC11provided by HGNC
Official Full Name
ATP binding cassette subfamily C member 11provided by HGNC
Primary source
HGNC:HGNC:14639
See related
Ensembl:ENSG00000121270 MIM:607040; Vega:OTTHUMG00000133146
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
WW; EWWD; MRP8
Summary
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This ABC full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. The product of this gene participates in physiological processes involving bile acids, conjugated steroids, and cyclic nucleotides. In addition, a SNP in this gene is responsible for determination of human earwax type. This gene and family member ABCC12 are determined to be derived by duplication and are both localized to chromosome 16q12.1. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2008]
Expression
Biased expression in testis (RPKM 1.2), prostate (RPKM 0.5) and 3 other tissues See more
Orthologs
See ABCC11 in Genome Data Viewer
Location:
16q12.1
Exon count:
40
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 16 NC_000016.10 (48164842..48249973, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (48200782..48281479, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2134 Neighboring gene ATP binding cassette subfamily C member 12 Neighboring gene lon peptidase 2, peroxisomal Neighboring gene ubiquitin A-52 residue ribosomal protein fusion product 1 pseudogene 8 Neighboring gene siah E3 ubiquitin protein ligase 1

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Associated conditions

Description Tests
Apocrine gland secretion, variation in
MedGen: C1861696 OMIM: 117800 GeneReviews: Not available
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NHGRI GWAS Catalog

Description
Genome-wide association meta-analysis identifies novel variants associated with fasting plasma glucose in East Asians.
NHGRI GWA Catalog
  • ABC transporters, organism-specific biosystem (from KEGG)
    ABC transporters, organism-specific biosystemThe ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of ...
  • ABC transporters, conserved biosystem (from KEGG)
    ABC transporters, conserved biosystemThe ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of ...
  • ABC-family proteins mediated transport, organism-specific biosystem (from REACTOME)
    ABC-family proteins mediated transport, organism-specific biosystemThe ATP-binding cassette (ABC) superfamily of active transporters involves a large number of functionally diverse transmembrane proteins. They transport a variety of compounds through membranes agai...
  • Transmembrane transport of small molecules, organism-specific biosystem (from REACTOME)
    Transmembrane transport of small molecules, organism-specific biosystem
    Transmembrane transport of small molecules

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATPase activity, coupled to transmembrane movement of substances IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ATPase-coupled anion transmembrane transporter activity TAS
Traceable Author Statement
more info
 
organic anion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
organic anion transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
purine nucleotide transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
purine nucleotide transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
ATP hydrolysis coupled anion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
organic anion transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
organic anion transport IDA
Inferred from Direct Assay
more info
PubMed 
purine nucleotide transport IDA
Inferred from Direct Assay
more info
PubMed 
transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transmembrane transport TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytoplasmic vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome HDA PubMed 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
vacuolar membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
ATP-binding cassette sub-family C member 11
Names
ATP-binding cassette protein C11
ATP-binding cassette transporter MRP8
ATP-binding cassette transporter sub-family C member 11
ATP-binding cassette, sub-family C (CFTR/MRP), member 11
multi-resistance protein 8
multidrug resistance-associated protein 8

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011522.1 RefSeqGene

    Range
    5001..73267
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_032583.3NP_115972.2  ATP-binding cassette sub-family C member 11 isoform a

    See identical proteins and their annotated locations for NP_115972.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1), as well as variant 2, encodes the predominant isoform (a).
    Source sequence(s)
    AF352582, AF411579, AY040219
    Consensus CDS
    CCDS10732.1
    UniProtKB/Swiss-Prot
    Q96J66
    UniProtKB/TrEMBL
    A0A024R6Q6
    Related
    ENSP00000378231.1, ENST00000394748.5
    Conserved Domains (4) summary
    cd03244
    Location:11391359
    ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
    cd03250
    Location:517709
    ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
    TIGR01271
    Location:851357
    CFTR_protein; cystic fibrosis transmembrane conductor regulator (CFTR)
    cl00549
    Location:8101087
    ABC_membrane; ABC transporter transmembrane region
  2. NM_033151.3NP_149163.2  ATP-binding cassette sub-family C member 11 isoform a

    See identical proteins and their annotated locations for NP_149163.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same predominant isoform (a).
    Source sequence(s)
    AF352582, AY040219
    Consensus CDS
    CCDS10732.1
    UniProtKB/Swiss-Prot
    Q96J66
    UniProtKB/TrEMBL
    A0A024R6Q6
    Related
    ENSP00000378230.1, OTTHUMP00000253663, ENST00000394747.5, OTTHUMT00000429984
    Conserved Domains (4) summary
    cd03244
    Location:11391359
    ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
    cd03250
    Location:517709
    ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
    TIGR01271
    Location:851357
    CFTR_protein; cystic fibrosis transmembrane conductor regulator (CFTR)
    cl00549
    Location:8101087
    ABC_membrane; ABC transporter transmembrane region
  3. NM_145186.2NP_660187.1  ATP-binding cassette sub-family C member 11 isoform b

    See identical proteins and their annotated locations for NP_660187.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1, resulting in a shorter protein (isoform b), compared to isoform a.
    Source sequence(s)
    AF352582, AF411579, AY040219
    Consensus CDS
    CCDS10733.1
    UniProtKB/Swiss-Prot
    Q96J66
    UniProtKB/TrEMBL
    A0A024R6R9
    Related
    ENSP00000311326.6, OTTHUMP00000164192, ENST00000353782.9, OTTHUMT00000256844
    Conserved Domains (4) summary
    cd03244
    Location:11391321
    ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
    cd03250
    Location:517709
    ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
    TIGR01271
    Location:851319
    CFTR_protein; cystic fibrosis transmembrane conductor regulator (CFTR)
    cl00549
    Location:8101087
    ABC_membrane; ABC transporter transmembrane region

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p12 Primary Assembly

    Range
    48164842..48249973 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017023801.2XP_016879290.1  ATP-binding cassette sub-family C member 11 isoform X2

  2. XM_017023795.2XP_016879284.1  ATP-binding cassette sub-family C member 11 isoform X1

    UniProtKB/Swiss-Prot
    Q96J66
    UniProtKB/TrEMBL
    A0A024R6Q6
    Related
    ENSP00000349017.2, OTTHUMP00000164191, ENST00000356608.6
    Conserved Domains (4) summary
    cd03244
    Location:11391359
    ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
    cd03250
    Location:517709
    ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
    TIGR01271
    Location:851357
    CFTR_protein; cystic fibrosis transmembrane conductor regulator (CFTR)
    cl00549
    Location:8101087
    ABC_membrane; ABC transporter transmembrane region
  3. XM_017023797.2XP_016879286.1  ATP-binding cassette sub-family C member 11 isoform X1

    UniProtKB/Swiss-Prot
    Q96J66
    UniProtKB/TrEMBL
    A0A024R6Q6
    Conserved Domains (4) summary
    cd03244
    Location:11391359
    ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
    cd03250
    Location:517709
    ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
    TIGR01271
    Location:851357
    CFTR_protein; cystic fibrosis transmembrane conductor regulator (CFTR)
    cl00549
    Location:8101087
    ABC_membrane; ABC transporter transmembrane region
  4. XM_017023798.2XP_016879287.1  ATP-binding cassette sub-family C member 11 isoform X1

    UniProtKB/Swiss-Prot
    Q96J66
    UniProtKB/TrEMBL
    A0A024R6Q6
    Conserved Domains (4) summary
    cd03244
    Location:11391359
    ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
    cd03250
    Location:517709
    ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
    TIGR01271
    Location:851357
    CFTR_protein; cystic fibrosis transmembrane conductor regulator (CFTR)
    cl00549
    Location:8101087
    ABC_membrane; ABC transporter transmembrane region
  5. XM_017023800.2XP_016879289.1  ATP-binding cassette sub-family C member 11 isoform X1

    UniProtKB/Swiss-Prot
    Q96J66
    UniProtKB/TrEMBL
    A0A024R6Q6
    Conserved Domains (4) summary
    cd03244
    Location:11391359
    ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
    cd03250
    Location:517709
    ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
    TIGR01271
    Location:851357
    CFTR_protein; cystic fibrosis transmembrane conductor regulator (CFTR)
    cl00549
    Location:8101087
    ABC_membrane; ABC transporter transmembrane region
  6. XM_017023796.2XP_016879285.1  ATP-binding cassette sub-family C member 11 isoform X1

    UniProtKB/Swiss-Prot
    Q96J66
    UniProtKB/TrEMBL
    A0A024R6Q6
    Conserved Domains (4) summary
    cd03244
    Location:11391359
    ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
    cd03250
    Location:517709
    ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
    TIGR01271
    Location:851357
    CFTR_protein; cystic fibrosis transmembrane conductor regulator (CFTR)
    cl00549
    Location:8101087
    ABC_membrane; ABC transporter transmembrane region
  7. XM_017023799.2XP_016879288.1  ATP-binding cassette sub-family C member 11 isoform X1

    UniProtKB/Swiss-Prot
    Q96J66
    UniProtKB/TrEMBL
    A0A024R6Q6
    Conserved Domains (4) summary
    cd03244
    Location:11391359
    ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
    cd03250
    Location:517709
    ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
    TIGR01271
    Location:851357
    CFTR_protein; cystic fibrosis transmembrane conductor regulator (CFTR)
    cl00549
    Location:8101087
    ABC_membrane; ABC transporter transmembrane region
  8. XM_011523397.2XP_011521699.1  ATP-binding cassette sub-family C member 11 isoform X3

    See identical proteins and their annotated locations for XP_011521699.1

    Conserved Domains (1) summary
    PLN03130
    Location:161052
    PLN03130; ABC transporter C family member; Provisional
  9. XM_024450475.1XP_024306243.1  ATP-binding cassette sub-family C member 11 isoform X3

    Conserved Domains (1) summary
    PLN03130
    Location:161052
    PLN03130; ABC transporter C family member; Provisional
  10. XM_017023802.2XP_016879291.1  ATP-binding cassette sub-family C member 11 isoform X3

    Conserved Domains (1) summary
    PLN03130
    Location:161052
    PLN03130; ABC transporter C family member; Provisional
  11. XM_011523398.3XP_011521700.1  ATP-binding cassette sub-family C member 11 isoform X5

    Conserved Domains (4) summary
    cd03244
    Location:516736
    ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
    COG1132
    Location:185753
    MdlB; ABC-type multidrug transport system, ATPase and permease component [Defense mechanisms]
    cl00549
    Location:187464
    ABC_membrane; ABC transporter transmembrane region
    cl21455
    Location:186
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  12. XM_017023803.1XP_016879292.1  ATP-binding cassette sub-family C member 11 isoform X4

RNA

  1. XR_001752012.1 RNA Sequence

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