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PUP2 proteasome core particle subunit alpha 5 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853168, updated on 10-Mar-2023

Summary

Gene symbol
PUP2
Gene description
proteasome core particle subunit alpha 5
Primary source
SGD:S000003485
Locus tag
YGR253C
See related
AllianceGenome:SGD:S000003485
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
DOA5
Summary
Involved in proteasomal ubiquitin-independent protein catabolic process and proteasome-mediated ubiquitin-dependent protein catabolic process. Located in proteasome storage granule. Part of proteasome core complex, alpha-subunit complex. Orthologous to human PSMA5 (proteasome 20S subunit alpha 5). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See PUP2 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (998358..999140, complement)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Nop19p Neighboring gene histone acetyltransferase GCN5 Neighboring gene phosphopyruvate hydratase ENO1 Neighboring gene putative N,N-dimethylaniline monooxygenase COQ6

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the PUP2 gene: The PUP2 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.
  • Orthologs

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear outer membrane-endoplasmic reticulum membrane network IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
part_of proteasome complex IEA
Inferred from Electronic Annotation
more info
 
part_of proteasome core complex IEA
Inferred from Electronic Annotation
more info
 
part_of proteasome core complex, alpha-subunit complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of proteasome core complex, alpha-subunit complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of proteasome core complex, alpha-subunit complex IEA
Inferred from Electronic Annotation
more info
 
located_in proteasome storage granule IDA
Inferred from Direct Assay
more info
PubMed 
located_in proteasome storage granule IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
proteasome core particle subunit alpha 5
NP_011769.1
  • Alpha 5 subunit of the 20S proteasome; involved in ubiquitin-dependent catabolism; human homolog is subunit zeta

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    998358..999140 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181382.1NP_011769.1  TPA: proteasome core particle subunit alpha 5 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011769.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VV33, P32379
    UniProtKB/TrEMBL
    A0A0L8VPR8, A0A6A5PXN2, A0A6C1DRW4, A6ZUR1, B3LHY7, C7GNH7, C8Z9E5, G2WEX9, H0GGY3, N1P678
    Conserved Domains (1) summary
    cd03753
    Location:8222
    proteasome_alpha_type_5; The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on top of one another forming ...