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RNR4 ribonucleotide-diphosphate reductase subunit RNR4 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853091, updated on 19-Jun-2024

Summary

Gene symbol
RNR4
Gene description
ribonucleotide-diphosphate reductase subunit RNR4
Primary source
FungiDB:YGR180C
Locus tag
YGR180C
See related
SGD:S000003412; AllianceGenome:SGD:S000003412; VEuPathDB:YGR180C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
CRT3; PSO3
Summary
Contributes to ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor. Involved in deoxyribonucleotide biosynthetic process. Located in cytoplasm and nucleus. Part of ribonucleoside-diphosphate reductase complex. Human ortholog(s) of this gene implicated in autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 5; mitochondrial DNA depletion syndrome 8a; mitochondrial DNA depletion syndrome 8b; and pancreatic cancer. Orthologous to human RRM2B (ribonucleotide reductase regulatory TP53 inducible subunit M2B) and RRM2 (ribonucleotide reductase regulatory subunit M2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See RNR4 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (855264..856301, complement)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Pbp1p Neighboring gene Okp1p Neighboring gene tRNA-Leu Neighboring gene protein translocase subunit TIM13

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Process Evidence Code Pubs
involved_in deoxyribonucleotide biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in deoxyribonucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ribonucleotide-diphosphate reductase subunit RNR4
NP_011696.3
  • Ribonucleotide-diphosphate reductase (RNR) small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits; relocalizes from nucleus to cytoplasm upon DNA replication stress; RNR4 has a paralog, RNR2, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    855264..856301 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181309.3NP_011696.3  TPA: ribonucleotide-diphosphate reductase subunit RNR4 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011696.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VUW4, P49723, Q66R92
    UniProtKB/TrEMBL
    A0A6A5PXA7, A6ZUJ2, B3LI51, C7GT18, C8Z975, G2WER0, N1P3W2
    Conserved Domains (1) summary
    cl00264
    Location:18345
    Ferritin_like; Ferritin-like superfamily of diiron-containing four-helix-bundle proteins