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ERG1 squalene monooxygenase [ Saccharomyces cerevisiae S288C ]

Gene ID: 853086, updated on 17-May-2024

Summary

Gene symbol
ERG1
Gene description
squalene monooxygenase
Primary source
FungiDB:YGR175C
Locus tag
YGR175C
See related
SGD:S000003407; AllianceGenome:SGD:S000003407; VEuPathDB:YGR175C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables squalene monooxygenase activity. Involved in ergosterol biosynthetic process. Located in endoplasmic reticulum and lipid droplet. Used to study cancer. Orthologous to human SQLE (squalene epoxidase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See ERG1 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (846933..848423, complement)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Cbp4p Neighboring gene uncharacterized protein Neighboring gene alcohol O-acetyltransferase Neighboring gene Pbp1p

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables squalene monooxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables squalene monooxygenase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables squalene monooxygenase activity IEA
Inferred from Electronic Annotation
more info
 
enables squalene monooxygenase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
involved_in ergosterol biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in ergosterol biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in ergosterol biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sterol biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in sterol metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in endoplasmic reticulum HDA PubMed 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
located_in lipid droplet IDA
Inferred from Direct Assay
more info
PubMed 
located_in lipid droplet IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
squalene monooxygenase
NP_011691.1
  • Squalene epoxidase; catalyzes epoxidation of squalene to 2,3-oxidosqualene; plays essential role in ergosterol-biosynthesis pathway and is specific target of antifungal drug terbinafine; directed to ER via guided entry of tail-anchored proteins (GET) pathway; degradation by ERAD triggered by membrane lipid saturation; human SQLE functionally complements the lethality of the erg1 null mutation

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    846933..848423 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181304.1NP_011691.1  TPA: squalene monooxygenase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011691.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VUW0, P32476
    UniProtKB/TrEMBL
    A0A6A5PXG6, A6ZUI8, B3LI54, C7GT22, C8Z972, G2WEQ6, N1P3V6
    Conserved Domains (3) summary
    PRK06370
    Location:1951
    PRK06370; FAD-containing oxidoreductase
    pfam08491
    Location:201473
    SE; Squalene epoxidase
    cl21454
    Location:1986
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins