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VMA21 Vma21p [ Saccharomyces cerevisiae S288C ]

Gene ID: 852997, updated on 3-Nov-2024

Summary

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Official Symbol
VMA21
Official Full Name
Vma21p
Primary source
SGD:S000003337
Locus tag
YGR105W
See related
AllianceGenome:SGD:S000003337; FungiDB:YGR105W; VEuPathDB:YGR105W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in vacuolar proton-transporting V-type ATPase complex assembly. Located in endoplasmic reticulum membrane. Used to study X-linked myopathy with excessive autophagy and follicular lymphoma. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See VMA21 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (698599..698832)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene mRNA-binding ribosome synthesis protein NOP7 Neighboring gene Srb5p Neighboring gene Voa1p Neighboring gene tRNA-Leu

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Vma21p is a yeast membrane protein retained in the endoplasmic reticulum by a di-lysine motif and is required for the assembly of the vacuolar H(+)-ATPase complex. Hill KJ, et al. Mol Biol Cell, 1994 Sep. PMID 7841520, Free PMC Article
  2. VMA12 is essential for assembly of the vacuolar H(+)-ATPase subunits onto the vacuolar membrane in Saccharomyces cerevisiae. Hirata R, et al. J Biol Chem, 1993 Jan 15. PMID 8419376
  3. Assembly of the yeast vacuolar proton-translocating ATPase. Graham LA, et al. J Bioenerg Biomembr, 1999 Feb. PMID 10340847
  4. Isolation of vacuolar membrane H(+)-ATPase-deficient yeast mutants; the VMA5 and VMA4 genes are essential for assembly and activity of the vacuolar H(+)-ATPase. Ho MN, et al. J Biol Chem, 1993 Jan 5. PMID 8416931
  5. Loss of vacuolar acidity results in iron-sulfur cluster defects and divergent homeostatic responses during aging in Saccharomyces cerevisiae. Chen KL, et al. Geroscience, 2020 Apr. PMID 31975050, Free PMC Article

See all (67) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in vacuolar proton-transporting V-type ATPase complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vacuolar proton-transporting V-type ATPase complex assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in vacuolar proton-transporting V-type ATPase complex assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in ER to Golgi transport vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum HDA PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum-Golgi intermediate compartment membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Vma21p
NP_011619.3
  • Integral membrane protein required for V-ATPase function; not actual component of vacuolar H+-ATPase (V-ATPase) complex; diverged ortholog of human VMA21/XMEA (X-linked Myopathy with Excessive Autophagy); functions in assembly of V-ATPase; localizes to endoplasmic reticulum (ER)

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    698599..698832
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181234.3 → NP_011619.3  TPA: Vma21p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011619.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A6ZV87, B3LIC1, D6VUN7, P41806, Q6Q5Q3
    UniProtKB/TrEMBL
    C7GWV8, C8Z8Z8, G2WEJ0, N1P9W3
    Conserved Domains (1) summary
    pfam09446
    Location:9 → 61
    VMA21; VMA21-like domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P41806.1

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