CYP4F2 cytochrome P450 family 4 subfamily F member 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: CYP4F2provided by HGNC
Official Full Name: cytochrome P450 family 4 subfamily F member 2provided by HGNC
Primary source: HGNC:HGNC:2645
See related: Ensembl:ENSG00000186115 MIM:604426
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CPF2
Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. The enzyme starts the process of inactivating and degrading leukotriene B4, a potent mediator of inflammation. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F11, is approximately 16 kb away. [provided by RefSeq, Jul 2008]
Expression: Biased expression in liver (RPKM 63.5), small intestine (RPKM 42.7) and 2 other tissues See more
Orthologs: all

Genomic context

Location:: 19p13.12

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
109.20200228	current	GRCh38.p13 (GCF_000001405.39)	19	NC_000019.10 (15878023..15898074, complement)
105	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (15988834..16008884, complement)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Aspirin use and CYP4F2 T allele were significantly associated with bleeding during dual antiplatelet therapy.
Title: The impact of CYP2C19 and CYP4F2 variants and clinical factors on treatment outcomes during antiplatelet therapy.
polymorphisms of CYP2C9, VKORC1 and CYP4F2 genes can influence the stable dose of warfarin in Shandong population.
Title: [Verification of accuracy of warfarin stable dose prediction models in Shandong population].
Patients whose donors carried the same CYP4F2 433M variant showed higher risk of acute rejection and lower glomerular filtration rate values.
Title: Polymorphisms in vasoactive eicosanoid genes of kidney donors affect biopsy scores and clinical outcomes in renal transplantation.
The CYP4F2*3 polymorphism was consistently associated with an increase in mean coumarin dose, with a higher effect in women and white patients.
Title: Effect of CYP4F2, VKORC1, and CYP2C9 in Influencing Coumarin Dose: A Single-Patient Data Meta-Analysis in More Than 15,000 Individuals.
Genetic variants in CYP4F2 were significantly correlated with susceptibility to ischemic stroke.
Title: Genetic variants in CYP4F2 were significantly correlated with susceptibility to ischemic stroke.
After incubating human liver microsomes expressing only recombinant human CYP-4F2, cytochrome b5, and NADPH P450 reductase with d6-alpha-tocopheryl quinone (d6-alphaTQ), the study showed that the omega-hydroxylated (13-OH) d6-alpha-TQ was produced.
Title: ω-Hydroxylation of α-tocopheryl quinone reveals a dual function for cytochrome P450-4F2 in vitamin E metabolism.
Meta-analysis demonstrates that the rs1558139 and rs2108622 single nucleotide polymorphisms of the CYP4F2 gene are associated with hypertension, with a particularly strong link between the rs1558139 polymorphism in males.
Title: Association Between the CYP4F2 Gene rs1558139 and rs2108622 Polymorphisms and Hypertension: A Meta-Analysis.
CYP4F2 affects phenotypic outcome in adrenoleukodystrophy by modulating the clearance of very long-chain fatty acids.
Title: CYP4F2 affects phenotypic outcome in adrenoleukodystrophy by modulating the clearance of very long-chain fatty acids.
CYP4F2 rs2108622 determines warfarin dose for Han Chinese atrial fibrillation patients undergoing catheter ablation.
Title: Impact of VKORC1, CYP4F2 and NQO1 gene variants on warfarin dose requirement in Han Chinese patients with catheter ablation for atrial fibrillation.
The allele frequency, haplotype distribution, new genetic variants and linkage disequilibrium of CYP4F2 in Koreans.
Title: Identification of novel CYP4F2 genetic variants exhibiting decreased catalytic activity in the conversion of arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE).

Submit: New GeneRIF Correction See all GeneRIFs (98)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

NHGRI GWAS Catalog

Description
A genome-wide assessment of variability in human serum metabolism. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
A genome-wide association study confirms VKORC1, CYP2C9, and CYP4F2 as principal genetic determinants of warfarin dose. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
A genome-wide association study of acenocoumarol maintenance dosage. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Genome-wide association study identifies common variants associated with circulating vitamin E levels. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Genome-wide association study identifies genetic determinants of warfarin responsiveness for Japanese. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Genome-wide association study identifies three common variants associated with serologic response to vitamin E supplementation in men. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Meta-analysis of genome-wide association studies for circulating phylloquinone concentrations. NHGRI GWA Catalog NHGRI GWA CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:482394

SHGC-12532 (e-PCR)
- UniSTS:41569

SHGC-12532 (e-PCR)
- UniSTS:23514

Homology

Homologs of the CYP4F2 gene: The CYP4F2 gene is conserved in chimpanzee, Rhesus monkey, cow, mouse, rat, and zebrafish.
Orthologs from Annotation Pipeline: 1 organisms have orthologs with human gene CYP4F2
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
alkane 1-monooxygenase activity	IDA Inferred from Direct Assay more info	PubMed
alpha-tocopherol omega-hydroxylase activity	IDA Inferred from Direct Assay more info	PubMed
arachidonic acid epoxygenase activity	IDA Inferred from Direct Assay more info	PubMed
arachidonic acid monooxygenase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
arachidonic acid omega-hydroxylase activity	IDA Inferred from Direct Assay more info	PubMed
aromatase activity	IEA Inferred from Electronic Annotation more info
heme binding	IEA Inferred from Electronic Annotation more info
iron ion binding	IEA Inferred from Electronic Annotation more info
leukotriene-B4 20-monooxygenase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
leukotriene-B4 20-monooxygenase activity	IDA Inferred from Direct Assay more info	PubMed
monooxygenase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	IDA Inferred from Direct Assay more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed
tocotrienol omega-hydroxylase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
arachidonic acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info	PubMed
arachidonic acid metabolic process	IDA Inferred from Direct Assay more info	PubMed
blood coagulation	TAS Traceable Author Statement more info	PubMed
drug metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
epoxygenase P450 pathway	IDA Inferred from Direct Assay more info	PubMed
icosanoid metabolic process	TAS Traceable Author Statement more info
leukotriene B4 catabolic process	IBA Inferred from Biological aspect of Ancestor more info	PubMed
leukotriene B4 catabolic process	IDA Inferred from Direct Assay more info	PubMed
leukotriene metabolic process	TAS Traceable Author Statement more info
long-chain fatty acid metabolic process	IDA Inferred from Direct Assay more info	PubMed
menaquinone catabolic process	IBA Inferred from Biological aspect of Ancestor more info	PubMed
menaquinone catabolic process	IDA Inferred from Direct Assay more info	PubMed
negative regulation of icosanoid secretion	IMP Inferred from Mutant Phenotype more info	PubMed
omega-hydroxylase P450 pathway	TAS Traceable Author Statement more info
oxidation-reduction process	IBA Inferred from Biological aspect of Ancestor more info	PubMed
oxidation-reduction process	IDA Inferred from Direct Assay more info	PubMed
phylloquinone catabolic process	IBA Inferred from Biological aspect of Ancestor more info	PubMed
phylloquinone catabolic process	IDA Inferred from Direct Assay more info	PubMed
phylloquinone catabolic process	IEA Inferred from Electronic Annotation more info
positive regulation of icosanoid secretion	IMP Inferred from Mutant Phenotype more info	PubMed
pressure natriuresis	IEP Inferred from Expression Pattern more info	PubMed
regulation of blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
renal water homeostasis	IEP Inferred from Expression Pattern more info	PubMed
sodium ion homeostasis	IEP Inferred from Expression Pattern more info	PubMed
very long-chain fatty acid metabolic process	IDA Inferred from Direct Assay more info	PubMed
vitamin E metabolic process	IDA Inferred from Direct Assay more info	PubMed
vitamin K catabolic process	IBA Inferred from Biological aspect of Ancestor more info	PubMed
vitamin K catabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
endoplasmic reticulum membrane	TAS Traceable Author Statement more info	PubMed
intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info	PubMed
intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: cytochrome P450 4F2

Names: 20-HETE synthase; 20-hydroxyeicosatetraenoic acid synthase; CYPIVF2; arachidonic acid omega-hydroxylase; cytochrome P450, family 4, subfamily F, polypeptide 2; cytochrome P450, subfamily IVF, polypeptide 2; cytochrome P450-LTB-omega; docosahexaenoic acid omega-hydroxylase; leukotriene-B(4) 20-monooxygenase 1; leukotriene-B(4) omega-hydroxylase 1; phylloquinone omega-hydroxylase CYP4F2

NP_001073.3

EC 1.14.14.1

EC 1.14.14.78

EC 1.14.14.79

EC 1.14.14.94

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.