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CYP4F2 cytochrome P450 family 4 subfamily F member 2 [ Homo sapiens (human) ]

Gene ID: 8529, updated on 26-Nov-2021

Summary

Official Symbol
CYP4F2provided by HGNC
Official Full Name
cytochrome P450 family 4 subfamily F member 2provided by HGNC
Primary source
HGNC:HGNC:2645
See related
Ensembl:ENSG00000186115 MIM:604426
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CPF2
Summary
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. The enzyme starts the process of inactivating and degrading leukotriene B4, a potent mediator of inflammation. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F11, is approximately 16 kb away. [provided by RefSeq, Jul 2008]
Expression
Biased expression in liver (RPKM 63.5), small intestine (RPKM 42.7) and 2 other tissues See more
Orthologs
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Genomic context

See CYP4F2 in Genome Data Viewer
Location:
19p13.12
Exon count:
13
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (15878023..15898074, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (15988833..16008884, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene C-type lectin domain family 4 member O, pseudogene Neighboring gene cytochrome P450 family 4 subfamily F member 36, pseudogene Neighboring gene RNA polymerase mitochondrial pseudogene Neighboring gene RNA polymerase mitochondrial pseudogene Neighboring gene inositol polyphosphate multikinase pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome-wide assessment of variability in human serum metabolism.
GeneReviews: Not available
A genome-wide association study confirms VKORC1, CYP2C9, and CYP4F2 as principal genetic determinants of warfarin dose.
GeneReviews: Not available
A genome-wide association study of acenocoumarol maintenance dosage.
GeneReviews: Not available
Genome-wide association study identifies common variants associated with circulating vitamin E levels.
GeneReviews: Not available
Genome-wide association study identifies genetic determinants of warfarin responsiveness for Japanese.
GeneReviews: Not available
Genome-wide association study identifies three common variants associated with serologic response to vitamin E supplementation in men.
GeneReviews: Not available
Meta-analysis of genome-wide association studies for circulating phylloquinone concentrations.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 20-aldehyde-leukotriene B4 20-monooxygenase activity TAS
Traceable Author Statement
more info
 
enables 20-hydroxy-leukotriene B4 omega oxidase activity TAS
Traceable Author Statement
more info
 
enables alkane 1-monooxygenase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables alpha-tocopherol omega-hydroxylase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables arachidonic acid epoxygenase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables arachidonic acid monooxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables arachidonic acid omega-hydroxylase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables aromatase activity IEA
Inferred from Electronic Annotation
more info
 
enables docosanoate omega-hydroxylase activity IEA
Inferred from Electronic Annotation
more info
 
enables heme binding IEA
Inferred from Electronic Annotation
more info
 
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
 
enables leukotriene-B4 20-monooxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables leukotriene-B4 20-monooxygenase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables leukotriene-B4 20-monooxygenase activity TAS
Traceable Author Statement
more info
 
enables long-chain fatty acid omega-hydroxylase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables monooxygenase activity TAS
Traceable Author Statement
more info
 
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables tocotrienol omega-hydroxylase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in arachidonic acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in arachidonic acid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in blood coagulation TAS
Traceable Author Statement
more info
PubMed 
involved_in epoxygenase P450 pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in fatty acid omega-oxidation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in icosanoid metabolic process TAS
Traceable Author Statement
more info
 
involved_in leukotriene B4 catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in leukotriene B4 catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in leukotriene metabolic process TAS
Traceable Author Statement
more info
 
involved_in long-chain fatty acid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in menaquinone catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in menaquinone catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of icosanoid secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in omega-hydroxylase P450 pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in omega-hydroxylase P450 pathway TAS
Traceable Author Statement
more info
 
involved_in phylloquinone catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in phylloquinone catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in phylloquinone catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of icosanoid secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in pressure natriuresis IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in regulation of blood pressure IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in renal water homeostasis IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in sodium ion homeostasis IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in very long-chain fatty acid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in vitamin E metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in vitamin K catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in xenobiotic metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
PubMed 
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
cytochrome P450 4F2
Names
20-HETE synthase
20-hydroxyeicosatetraenoic acid synthase
CYPIVF2
arachidonic acid omega-hydroxylase
cytochrome P450, family 4, subfamily F, polypeptide 2
cytochrome P450, subfamily IVF, polypeptide 2
cytochrome P450-LTB-omega
docosahexaenoic acid omega-hydroxylase
leukotriene-B(4) 20-monooxygenase 1
leukotriene-B(4) omega-hydroxylase 1
phylloquinone omega-hydroxylase CYP4F2
NP_001073.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007971.2 RefSeqGene

    Range
    5001..25052
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001082.5NP_001073.3  cytochrome P450 4F2 precursor

    See identical proteins and their annotated locations for NP_001073.3

    Status: REVIEWED

    Source sequence(s)
    AC004791, AK290790, BC067439, DC362034, U02388
    Consensus CDS
    CCDS12336.1
    UniProtKB/Swiss-Prot
    P78329
    Related
    ENSP00000221700.3, ENST00000221700.11
    Conserved Domains (2) summary
    pfam00067
    Location:52515
    p450; Cytochrome P450
    pfam13779
    Location:457
    DUF4175; Domain of unknown function (DUF4175)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    15878023..15898074 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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