CYP4F2 cytochrome P450 family 4 subfamily F member 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: CYP4F2provided by HGNC
Official Full Name: cytochrome P450 family 4 subfamily F member 2provided by HGNC
Primary source: HGNC:HGNC:2645
See related: Ensembl:ENSG00000186115 MIM:604426
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CPF2
Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. The enzyme starts the process of inactivating and degrading leukotriene B4, a potent mediator of inflammation. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F11, is approximately 16 kb away. [provided by RefSeq, Jul 2008]
Expression: Biased expression in liver (RPKM 63.5), small intestine (RPKM 42.7) and 2 other tissues See more
Orthologs: all
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Genomic context

Location:: 19p13.12

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
109.20211119	current	GRCh38.p13 (GCF_000001405.39)	19	NC_000019.10 (15878023..15898074, complement)
105.20201022	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (15988833..16008884, complement)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Influence of CYP4F2, ApoE, and CYP2A6 gene polymorphisms on the variability of Warfarin dosage requirements and susceptibility to cardiovascular disease in Jordan.
Title: Influence of CYP4F2, ApoE, and CYP2A6 gene polymorphisms on the variability of Warfarin dosage requirements and susceptibility to cardiovascular disease in Jordan.
Impact of VKORC1, CYP2C9, and CYP4F2 Polymorphisms on Optimal Warfarin Dose: Does Ethnicity Matters?
Title: Impact of VKORC1, CYP2C9, and CYP4F2 Polymorphisms on Optimal Warfarin Dose: Does Ethnicity Matters?
CYP4F2 and CYP3A5 gene polymorphisms and lung cancer in Chinese Han population.
Title: CYP4F2 and CYP3A5 gene polymorphisms and lung cancer in Chinese Han population.
Association of genetic variants at CETP, AGER, and CYP4F2 locus with the risk of atrophic age-related macular degeneration.
Title: Association of genetic variants at CETP, AGER, and CYP4F2 locus with the risk of atrophic age-related macular degeneration.
CYP4F2 and VKORC1 Polymorphisms Amplify the Risk of Carotid Plaque Formation.
Title: CYP4F2 and VKORC1 Polymorphisms Amplify the Risk of Carotid Plaque Formation.
The correlation between CYP4F2 variants and chronic obstructive pulmonary disease risk in Hainan Han population.
Title: The correlation between CYP4F2 variants and chronic obstructive pulmonary disease risk in Hainan Han population.
A Genome-wide Association Study Discovers 46 Loci of the Human Metabolome in the Hispanic Community Health Study/Study of Latinos.
Title: A Genome-wide Association Study Discovers 46 Loci of the Human Metabolome in the Hispanic Community Health Study/Study of Latinos.
The serum selenium level is negatively correlated with CAD. The polymorphism of the CYP4F2 rs3093135 and CTRP9 rs9553238 was significantly related to the susceptibility of CAD, and there is a synergistic effect between the serum selenium level and the CTRP9 rs9553238 CC genotype, which significantly increases the risk of CAD.
Title: Association of CYP4F2 and CTRP9 polymorphisms and serum selenium levels with coronary artery disease.
Patients with stable angina pectoris had higher hsa-miR-24-3p and hsa-miR-34a-5p expression, but lower CYP4F2 enzyme levels in blood plasma.
Title: New potential modulators of CYP4F2 enzyme activity in angina pectoris: hsa-miR-24-3p and hsa-miR-34a-5p.
Aspirin use and CYP4F2 T allele were significantly associated with bleeding during dual antiplatelet therapy.
Title: The impact of CYP2C19 and CYP4F2 variants and clinical factors on treatment outcomes during antiplatelet therapy.

Submit: New GeneRIF Correction See all GeneRIFs (107)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
A genome-wide assessment of variability in human serum metabolism. GeneReviews: Not available
A genome-wide association study confirms VKORC1, CYP2C9, and CYP4F2 as principal genetic determinants of warfarin dose. GeneReviews: Not available
A genome-wide association study of acenocoumarol maintenance dosage. GeneReviews: Not available
Genome-wide association study identifies common variants associated with circulating vitamin E levels. GeneReviews: Not available
Genome-wide association study identifies genetic determinants of warfarin responsiveness for Japanese. GeneReviews: Not available
Genome-wide association study identifies three common variants associated with serologic response to vitamin E supplementation in men. GeneReviews: Not available
Meta-analysis of genome-wide association studies for circulating phylloquinone concentrations. GeneReviews: Not available

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:482394

SHGC-12532 (e-PCR)
- UniSTS:41569

SHGC-12532 (e-PCR)
- UniSTS:23514

Homology

Homologs of the CYP4F2 gene: The CYP4F2 gene is conserved in chimpanzee, Rhesus monkey, cow, mouse, rat, and zebrafish.
Orthologs from Annotation Pipeline: 1 organisms have orthologs with human gene CYP4F2
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables 20-aldehyde-leukotriene B4 20-monooxygenase activity	TAS Traceable Author Statement more info
enables 20-hydroxy-leukotriene B4 omega oxidase activity	TAS Traceable Author Statement more info
enables alkane 1-monooxygenase activity	IDA Inferred from Direct Assay more info	PubMed
enables alpha-tocopherol omega-hydroxylase activity	IDA Inferred from Direct Assay more info	PubMed
enables arachidonic acid epoxygenase activity	IDA Inferred from Direct Assay more info	PubMed
enables arachidonic acid monooxygenase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables arachidonic acid omega-hydroxylase activity	IDA Inferred from Direct Assay more info	PubMed
enables aromatase activity	IEA Inferred from Electronic Annotation more info
enables docosanoate omega-hydroxylase activity	IEA Inferred from Electronic Annotation more info
enables heme binding	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables leukotriene-B4 20-monooxygenase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables leukotriene-B4 20-monooxygenase activity	IDA Inferred from Direct Assay more info	PubMed
enables leukotriene-B4 20-monooxygenase activity	TAS Traceable Author Statement more info
enables long-chain fatty acid omega-hydroxylase activity	IDA Inferred from Direct Assay more info	PubMed
enables monooxygenase activity	TAS Traceable Author Statement more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables tocotrienol omega-hydroxylase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in arachidonic acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in arachidonic acid metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in blood coagulation	TAS Traceable Author Statement more info	PubMed
involved_in epoxygenase P450 pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in fatty acid omega-oxidation	IDA Inferred from Direct Assay more info	PubMed
involved_in icosanoid metabolic process	TAS Traceable Author Statement more info
involved_in leukotriene B4 catabolic process	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in leukotriene B4 catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in leukotriene metabolic process	TAS Traceable Author Statement more info
involved_in long-chain fatty acid metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in menaquinone catabolic process	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in menaquinone catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of icosanoid secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in omega-hydroxylase P450 pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in omega-hydroxylase P450 pathway	TAS Traceable Author Statement more info
involved_in phylloquinone catabolic process	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in phylloquinone catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in phylloquinone catabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of icosanoid secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pressure natriuresis	IEP Inferred from Expression Pattern more info	PubMed
involved_in regulation of blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in renal water homeostasis	IEP Inferred from Expression Pattern more info	PubMed
involved_in sodium ion homeostasis	IEP Inferred from Expression Pattern more info	PubMed
involved_in very long-chain fatty acid metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in vitamin E metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in vitamin K catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in xenobiotic metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	TAS Traceable Author Statement more info	PubMed
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: cytochrome P450 4F2

Names: 20-HETE synthase; 20-hydroxyeicosatetraenoic acid synthase; CYPIVF2; arachidonic acid omega-hydroxylase; cytochrome P450, family 4, subfamily F, polypeptide 2; cytochrome P450, subfamily IVF, polypeptide 2; cytochrome P450-LTB-omega; docosahexaenoic acid omega-hydroxylase; leukotriene-B(4) 20-monooxygenase 1; leukotriene-B(4) omega-hydroxylase 1; phylloquinone omega-hydroxylase CYP4F2

NP_001073.3

EC 1.14.14.1

EC 1.14.14.78

EC 1.14.14.79

EC 1.14.14.94

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.