U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

PRP18 mRNA splicing protein PRP18 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852889, updated on 17-May-2024

Summary

Gene symbol
PRP18
Gene description
mRNA splicing protein PRP18
Primary source
FungiDB:YGR006W
Locus tag
YGR006W
See related
SGD:S000003238; AllianceGenome:SGD:S000003238
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Contributes to second spliceosomal transesterification activity. Involved in generation of catalytic spliceosome for second transesterification step and nuclear retention of unspliced pre-mRNA at the site of transcription. Part of U2-type post-spliceosomal complex; U4/U6 x U5 tri-snRNP complex; and U5 snRNP. Orthologous to human PRPF18 (pre-mRNA processing factor 18). [provided by Alliance of Genome Resources, Apr 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (506070..506825)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene peroxisome biogenesis protein Neighboring gene transcription factor IIF subunit TFG2 Neighboring gene ethanolamine-phosphate cytidylyltransferase Neighboring gene ATPase-stabilizing factor family protein

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Component Evidence Code Pubs
part_of U2-type post-spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of U2-type post-spliceosomal complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of U4/U6 x U5 tri-snRNP complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of U4/U6 x U5 tri-snRNP complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of U5 snRNP IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of U5 snRNP IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
part_of spliceosomal complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
mRNA splicing protein PRP18
NP_011520.2
  • Splicing factor and component of snRNP U5; factor involved in the positioning of the 3' splice site during the second catalytic step of splicing; interacts with Slu7p

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    506070..506825
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181135.1NP_011520.2  TPA: mRNA splicing protein PRP18 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011520.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VUE3, P33411, Q02459, Q05724
    UniProtKB/TrEMBL
    A0A6A5PX22, A6ZUZ8, B3LIL0, C7GK76, C8Z8Q0, G2WE99, N1P217
    Conserved Domains (1) summary
    pfam02840
    Location:116243
    Prp18; Prp18 domain