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ERG26 sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) [ Saccharomyces cerevisiae S288C ]

Gene ID: 852883, updated on 10-Feb-2026
Official Symbol
ERG26
Official Full Name
sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating)
Primary source
SGD:S000002969
Locus tag
YGL001C
See related
AllianceGenome:SGD:S000002969; FungiDB:YGL001C; VEuPathDB:YGL001C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables 3-beta-hydroxysteroid dehydrogenase (NAD+)/C4-decarboxylase activity. Involved in ergosterol biosynthetic process. Located in endoplasmic reticulum membrane. Is active in endoplasmic reticulum. Used to study cancer. Human ortholog(s) of this gene implicated in CHILD syndrome and CK syndrome. Orthologous to human NSDHL (NAD(P) dependent 3-beta-hydroxysteroid dehydrogenase NSDHL). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See ERG26 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (495453..496502, complement)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Cdh1p Neighboring gene Erp6p Neighboring gene protein-lysine N-methyltransferase Neighboring gene Swc4p

Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. The Candida albicans ERG26 gene encoding the C-3 sterol dehydrogenase (C-4 decarboxylase) is essential for growth. Aaron KE, et al. FEMS Yeast Res, 2001 Jul. PMID 12702354
  2. Characterization of the Saccharomyces cerevisiae ERG26 gene encoding the C-3 sterol dehydrogenase (C-4 decarboxylase) involved in sterol biosynthesis. Gachotte D, et al. Proc Natl Acad Sci U S A, 1998 Nov 10. PMID 9811880, Free PMC Article
  3. Hypomorphic temperature-sensitive alleles of NSDHL cause CK syndrome. McLarren KW, et al. Am J Hum Genet, 2010 Dec 10. PMID 21129721, Free PMC Article
  4. The effect of the erg26-1 mutation on the regulation of lipid metabolism in Saccharomyces cerevisiae. Baudry K, et al. J Biol Chem, 2001 Apr 20. PMID 11279045
  5. Sterol-dependent regulation of sphingolipid metabolism in Saccharomyces cerevisiae. Swain E, et al. J Biol Chem, 2002 Jul 19. PMID 12006573

See all (61) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables 3-beta-hydroxysteroid dehydrogenase (NAD+)/C4-decarboxylase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables 3-beta-hydroxysteroid dehydrogenase [NAD(P)+]/C4-decarboxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3-beta-hydroxysteroid dehydrogenase [NAD(P)+]/C4-decarboxylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 3-beta-hydroxysteroid dehydrogenase [NAD(P)+]/C4-decarboxylase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in ergosterol biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ergosterol biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in ergosterol biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in steroid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in steroid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in sterol biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum HDA PubMed 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating)
NP_011514.1
  • C-3 sterol dehydrogenase; catalyzes the second of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; human homolog NSDHL implicated in CK syndrome, and can complement yeast null mutant; molecular target of natural product and antifungal compound FR171456

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    495453..496502 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180866.1 → NP_011514.1  sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating)

    See identical proteins and their annotated locations for NP_011514.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VUD7, P53199
    UniProtKB/TrEMBL
    A6ZUZ2, B3LIL6, B5VIW1, C7GK71, C8Z8P4, G2WE93, N1P3D7
    Conserved Domains (1) summary
    cd09813
    Location:6 → 345
    3b-HSD-NSDHL-like_SDR_e; human NSDHL (NAD(P)H steroid dehydrogenase-like protein)-like, extended (e) SDRs
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53199.1

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