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HOP2 Hop2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 852850, updated on 18-Jan-2023

Summary

Gene symbol
HOP2
Gene description
Hop2p
Primary source
SGD:S000003001
Locus tag
YGL033W
See related
AllianceGenome:SGD:S000003001
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables double-stranded DNA binding activity. Involved in homologous chromosome pairing at meiosis and reciprocal meiotic recombination. Located in condensed nuclear chromosome. Human ortholog(s) of this gene implicated in ovarian dysgenesis 3. Orthologous to human PSMC3IP (PSMC3 interacting protein). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See HOP2 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
3
Sequence:
Chromosome: VII; NC_001139.9 (435625..436401)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene transcription factor MIG1 Neighboring gene uncharacterized protein Neighboring gene Aga2p Neighboring gene ribosomal 60S subunit protein L24A

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables double-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables double-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables recombinase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in DNA recombination IEA
Inferred from Electronic Annotation
more info
 
involved_in homologous chromosome pairing at meiosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in homologous chromosome pairing at meiosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in meiotic joint molecule formation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in meiotic strand invasion involved in reciprocal meiotic recombination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in nucleic acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in reciprocal meiotic recombination IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of DNA recombinase auxiliary factor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in condensed nuclear chromosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in condensed nuclear chromosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
Hop2p
NP_011482.3
  • Meiosis-specific protein that localizes to chromosomes; prevents synapsis between nonhomologous chromosomes and ensures synapsis between homologs; forms complex with Mnd1p to promote homolog pairing and meiotic double-strand break repair; heterodimer of Hop2p-Mnd1p stimulates the Dmc1p-mediated strand invasion

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    435625..436401
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180898.2NP_011482.3  TPA: Hop2p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011482.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O74245, P53187
    Conserved Domains (1) summary
    pfam07106
    Location:1879
    TBPIP; Tat binding protein 1(TBP-1)-interacting protein (TBPIP)