HOP2 Hop2p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: HOP2
Official Full Name: Hop2p
Primary source: SGD:S000003001
Locus tag: YGL033W
See related: AllianceGenome:SGD:S000003001; FungiDB:YGL033W; VEuPathDB:YGL033W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables double-stranded DNA binding activity. Involved in homologous chromosome pairing at meiosis and reciprocal meiotic recombination. Located in condensed nuclear chromosome. Human ortholog(s) of this gene implicated in ovarian dysgenesis 3. Orthologous to human PSMC3IP (PSMC3 interacting protein). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:: chromosome: VII

Exon count:: 3

Sequence:: Chromosome: VII; NC_001139.9 (435625..436401)

Chromosome VII - NC_001139.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Two auxiliary factors promote Dmc1-driven DNA strand exchange via stepwise mechanisms.
Title: Two auxiliary factors promote Dmc1-driven DNA strand exchange via stepwise mechanisms.
Hop2-Mnd1 bound rapidlyto Dmc1-ssDNA filaments with high affinity and remained bound for approximately 1.3 min before dissociating.
Title: Dynamic interactions of the homologous pairing 2 (Hop2)-meiotic nuclear divisions 1 (Mnd1) protein complex with meiotic presynaptic filaments in budding yeast.
Study provides evidence that both Hop2 and Sae3 promote homolog bias through a Dmc1-mediated double-strand break repair during meiosis.
Title: Hop2 and Sae3 Are Required for Dmc1-Mediated Double-Strand Break Repair via Homolog Bias during Meiosis.
findings allow us to propose a model explaining how Hop2-Mnd1 juxtaposes Dmc1-bound ssDNA with distorted recipient double-stranded DNA and thus facilitates strand invasion
Title: Crystal structure of Hop2-Mnd1 and mechanistic insights into its role in meiotic recombination.
The third exon of HOP2 is required for calcium-dependent and recombinase Dmc1-specific stimulation of homologous strand assimilation.
Title: The third exon of the budding yeast meiotic recombination gene HOP2 is required for calcium-dependent and recombinase Dmc1-specific stimulation of homologous strand assimilation.
bipartite mechanism of Hop2-Mnd1 in homologous DNA pairing: stabilization of the Rad51 presynaptic filament and duplex DNA capture to enhance synaptic complex formation
Title: Bipartite stimulatory action of the Hop2-Mnd1 complex on the Rad51 recombinase.
HOP2 facilitates Dmc1-dependent interhomolog crossover formation in meiosis.
Title: Mnd1/Hop2 facilitates Dmc1-dependent interhomolog crossover formation in meiosis of budding yeast.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables double-stranded DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables recombinase activator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in DNA recombination	IEA Inferred from Electronic Annotation more info
involved_in homologous chromosome pairing at meiosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in homologous chromosome pairing at meiosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in meiotic joint molecule formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in meiotic strand invasion involved in reciprocal meiotic recombination	IBA Inferred from Biological aspect of Ancestor more info
involved_in reciprocal meiotic recombination	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of DNA recombinase auxiliary factor complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in condensed nuclear chromosome	IBA Inferred from Biological aspect of Ancestor more info
located_in condensed nuclear chromosome	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Hop2p

NP_011482.3

Meiosis-specific protein that localizes to chromosomes; prevents synapsis between nonhomologous chromosomes and ensures synapsis between homologs; forms complex with Mnd1p to promote homolog pairing and meiotic double-strand break repair; heterodimer of Hop2p-Mnd1p stimulates the Dmc1p-mediated strand invasion

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001139.9 Reference assembly

Range

435625..436401

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180898.2 → NP_011482.3 TPA: Hop2p [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_011482.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VUA5, O74245, P53187

UniProtKB/TrEMBL

A0A059UDV5

Conserved Domains (1) summary

pfam07106
Location:18 → 79

TBPIP; Tat binding protein 1(TBP-1)-interacting protein (TBPIP)