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VVS1 Vvs1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 852543, updated on 18-Sep-2024

Summary

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Official Symbol
VVS1
Official Full Name
Vvs1p
Primary source
SGD:S000000445
Locus tag
YBR241C
See related
AllianceGenome:SGD:S000000445; FungiDB:YBR241C; VEuPathDB:YBR241C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Located in fungal-type vacuole membrane. Human ortholog(s) of this gene implicated in several diseases, including brain disease (multiple); carbohydrate metabolic disorder (multiple); myelomeningocele; obesity; and type 2 diabetes mellitus. Orthologous to several human genes including SLC2A3 (solute carrier family 2 member 3) and SLC2A4 (solute carrier family 2 member 4). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (702589..704055, complement)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Ert1p Neighboring gene Thi2p Neighboring gene 5'-deoxynucleotidase Neighboring gene UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A phylogenetic analysis of the sugar porters in hemiascomycetous yeasts. Palma M, et al. J Mol Microbiol Biotechnol, 2007. PMID 17587872
  2. Organelle acidification is important for localisation of vacuolar proteins in Saccharomyces cerevisiae. Matsumoto R, et al. Protoplasma, 2013 Dec. PMID 23708375
  3. The yeast vacuolar membrane proteome. Wiederhold E, et al. Mol Cell Proteomics, 2009 Feb. PMID 19001347
  4. Complete DNA sequence of yeast chromosome II. Feldmann H, et al. EMBO J, 1994 Dec 15. PMID 7813418, Free PMC Article
  5. An in vivo map of the yeast protein interactome. Tarassov K, et al. Science, 2008 Jun 13. PMID 18467557

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables hexose transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in hexose transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monosaccharide transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
located_in fungal-type vacuole membrane HDA PubMed 
located_in fungal-type vacuole membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in vacuolar membrane IEA
Inferred from Electronic Annotation
more info
  
located_in vacuole IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Vvs1p
NP_009800.1
  • Putative transporter, member of the sugar porter family; localizes to the vacuolar membrane; non-essential gene; upregulated by and required for tolerance to 4-Methylcyclohexane methanol; YBR241C has a paralog, VPS73, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    702589..704055 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178589.1 → NP_009800.1  TPA: Vvs1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009800.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQN7, P38142, Q6B2Y5
    UniProtKB/TrEMBL
    B3LMS1, B5VEJ1, C7GMR3, D3UEY9, N1P743
    Conserved Domains (1) summary
    cd17357
    Location:28 → 478
    MFS_GLUT_Class1_2_like; Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38142.1

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