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DGKZ diacylglycerol kinase zeta [ Homo sapiens (human) ]

Gene ID: 8525, updated on 3-Oct-2018

Summary

Official Symbol
DGKZprovided by HGNC
Official Full Name
diacylglycerol kinase zetaprovided by HGNC
Primary source
HGNC:HGNC:2857
See related
Ensembl:ENSG00000149091 MIM:601441; Vega:OTTHUMG00000166437
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DAGK5; DAGK6; DGK-ZETA; hDGKzeta
Summary
The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It may attenuate protein kinase C activity by regulating diacylglycerol levels in intracellular signaling cascade and signal transduction. Alternative splicing occurs at this locus and multiple transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Nov 2010]
Expression
Ubiquitous expression in brain (RPKM 24.7), bone marrow (RPKM 15.6) and 24 other tissues See more
Orthologs

Genomic context

See DGKZ in Genome Data Viewer
Location:
11p11.2
Exon count:
36
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 11 NC_000011.10 (46332905..46380554)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (46354455..46402104)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2489 Neighboring gene cAMP responsive element binding protein 3 like 1 Neighboring gene microRNA 4688 Neighboring gene cholinergic receptor muscarinic 4 Neighboring gene midkine

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Association of IFIH1 and other autoimmunity risk alleles with selective IgA deficiency.
NHGRI GWA Catalog

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
NAD+ kinase activity IEA
Inferred from Electronic Annotation
more info
 
diacylglycerol kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
diacylglycerol kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
diacylglycerol kinase activity TAS
Traceable Author Statement
more info
 
kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell migration NAS
Non-traceable Author Statement
more info
PubMed 
diacylglycerol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
diacylglycerol metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
glycerolipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glycerolipid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
lipid phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lipid phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidic acid biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
phosphatidic acid biosynthetic process TAS
Traceable Author Statement
more info
PubMed 
platelet activation TAS
Traceable Author Statement
more info
 
positive regulation of 1-phosphatidylinositol-4-phosphate 5-kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein kinase C-activating G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
lamellipodium IDA
Inferred from Direct Assay
more info
PubMed 
nuclear speck IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
postsynaptic density IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
diacylglycerol kinase zeta
Names
DAG kinase zeta
diacylglycerol kinase, zeta 104kDa
diglyceride kinase zeta
NP_001099010.1
NP_001186195.1
NP_001186196.1
NP_001186197.1
NP_003637.2
NP_963290.1
NP_963291.2
XP_005253239.1
XP_016873944.1
XP_016873945.1
XP_024304497.1
XP_024304498.1
XP_024304499.1
XP_024304500.1
XP_024304501.1
XP_024304502.1
XP_024304503.1
XP_024304504.1
XP_024304505.1
XP_024304506.1
XP_024304507.1
XP_024304508.1
XP_024304509.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047092.1 RefSeqGene

    Range
    5001..52650
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001105540.1NP_001099010.1  diacylglycerol kinase zeta isoform 4

    See identical proteins and their annotated locations for NP_001099010.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) encodes the longest isoform (4).
    Source sequence(s)
    AC116021, U94905
    Consensus CDS
    CCDS41640.1
    UniProtKB/Swiss-Prot
    Q13574
    Related
    ENSP00000412178.1, OTTHUMP00000232891, ENST00000454345.5, OTTHUMT00000389772
    Conserved Domains (7) summary
    smart00045
    Location:635792
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:486607
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    COG1597
    Location:482805
    LCB5; Diacylglycerol kinase family enzyme [Lipid transport and metabolism, General function prediction only]
    cd00204
    Location:9831099
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam00130
    Location:361420
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam12796
    Location:9831077
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:9831009
    ANK; ANK repeat [structural motif]
  2. NM_001199266.1NP_001186195.1  diacylglycerol kinase zeta isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) has an alternate 5' sequence including the coding region and extra nts CAG and an extra segment at alternate splice sites, respectively, in the CDS, compared to variant 4. The resulting isoform (5) has a shorter and distinct N-terminus, and an internal additional aa and an additional segment, compared to isoform 4.
    Source sequence(s)
    AK225774, CB959911, U51477
    Consensus CDS
    CCDS55757.1
    UniProtKB/Swiss-Prot
    Q13574
    Related
    ENSP00000436291.1, OTTHUMP00000233029, ENST00000527911.5, OTTHUMT00000389999
    Conserved Domains (7) summary
    smart00045
    Location:447604
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:298419
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    COG1597
    Location:294617
    LCB5; Diacylglycerol kinase family enzyme [Lipid transport and metabolism, General function prediction only]
    cd00204
    Location:795916
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:795894
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:795821
    ANK; ANK repeat [structural motif]
    cl00040
    Location:173232
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
  3. NM_001199267.1NP_001186196.1  diacylglycerol kinase zeta isoform 6

    See identical proteins and their annotated locations for NP_001186196.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) has an alternate 5' sequence including the coding region compared to variant 4. The resulting isoform (6) has a shorter and distinct N-terminus, compared to isoform 4.
    Source sequence(s)
    CB959911, U51477
    Consensus CDS
    CCDS55759.1
    UniProtKB/Swiss-Prot
    Q13574
    Related
    ENSP00000395684.2, OTTHUMP00000238021, ENST00000456247.6, OTTHUMT00000398328
    Conserved Domains (7) summary
    smart00045
    Location:446603
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:297418
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    COG1597
    Location:293616
    LCB5; Diacylglycerol kinase family enzyme [Lipid transport and metabolism, General function prediction only]
    cd00204
    Location:794910
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:794888
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:794820
    ANK; ANK repeat [structural motif]
    cl00040
    Location:172231
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
  4. NM_001199268.1NP_001186197.1  diacylglycerol kinase zeta isoform 7

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) has an alternate 5' sequence including the coding region and extra nts CAG at an alternate splice site in the CDS, and lacks an in-frame coding exon, compared to variant 4. The resulting isoform (7) has a shorter and distinct N-terminus and an internal additional aa, and lacks an internal segment, compared to isoform 4.
    Source sequence(s)
    AK294888, CB959911, U51477
    Consensus CDS
    CCDS55758.1
    UniProtKB/Swiss-Prot
    Q13574
    Related
    ENSP00000320340.8, OTTHUMP00000274878, ENST00000318201.12, OTTHUMT00000474167
    Conserved Domains (6) summary
    smart00045
    Location:424581
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:275396
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    COG1597
    Location:271594
    LCB5; Diacylglycerol kinase family enzyme [Lipid transport and metabolism, General function prediction only]
    cd00204
    Location:772888
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:772866
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:772798
    ANK; ANK repeat [structural motif]
  5. NM_003646.3NP_003637.2  diacylglycerol kinase zeta isoform 2

    See identical proteins and their annotated locations for NP_003637.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an alternate 5' sequence including the coding region and extra nts CAG at an alternate splice site in the CDS, compared to variant 4. The resulting isoform (2) has a shorter and distinct N-terminus and an internal additional aa, compared to isoform 4.
    Source sequence(s)
    BU849628, CB959911, U94905
    Consensus CDS
    CCDS44580.1
    UniProtKB/Swiss-Prot
    Q13574
    Related
    ENSP00000391021.2, OTTHUMP00000238022, ENST00000421244.6, OTTHUMT00000398329
    Conserved Domains (7) summary
    smart00045
    Location:447604
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:298419
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    COG1597
    Location:294617
    LCB5; Diacylglycerol kinase family enzyme [Lipid transport and metabolism, General function prediction only]
    cd00204
    Location:795911
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:795889
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:795821
    ANK; ANK repeat [structural motif]
    cl00040
    Location:173232
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
  6. NM_201532.2NP_963290.1  diacylglycerol kinase zeta isoform 1

    See identical proteins and their annotated locations for NP_963290.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) has an alternate 5' sequence including the coding region, compared to variant 4. The resulting isoform (1) has a shorter and distinct N-terminus, compared to isoform 4.
    Source sequence(s)
    AK124594, U51477
    Consensus CDS
    CCDS7918.1
    UniProtKB/Swiss-Prot
    Q13574
    Related
    ENSP00000343065.6, OTTHUMP00000232889, ENST00000343674.10, OTTHUMT00000389770
    Conserved Domains (7) summary
    smart00045
    Location:463620
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:314435
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    COG1597
    Location:310633
    LCB5; Diacylglycerol kinase family enzyme [Lipid transport and metabolism, General function prediction only]
    cd00204
    Location:811927
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:811905
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:811837
    ANK; ANK repeat [structural motif]
    cl00040
    Location:189248
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
  7. NM_201533.3NP_963291.2  diacylglycerol kinase zeta isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has an alternate 5' sequence including the coding region, lacks nts GAG at an alternate splice site and has extra nts CAG at another alternate splice sites in the CDS, compared to variant 4. The resulting isoform (3) has a shorter and distinct N-terminus, lacks an internal aa in one region and has an additional aa in another region, compared to isoform 4.
    Source sequence(s)
    AK300577, DC416889, U51477
    Consensus CDS
    CCDS44579.2
    UniProtKB/Swiss-Prot
    Q13574
    Related
    ENSP00000436273.2, OTTHUMP00000233028, ENST00000532868.6, OTTHUMT00000389998
    Conserved Domains (7) summary
    smart00045
    Location:451608
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:302423
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    COG1597
    Location:298621
    LCB5; Diacylglycerol kinase family enzyme [Lipid transport and metabolism, General function prediction only]
    cd00204
    Location:799915
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:799893
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:799825
    ANK; ANK repeat [structural motif]
    cl00040
    Location:177236
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p12 Primary Assembly

    Range
    46332905..46380554
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024448733.1XP_024304501.1  diacylglycerol kinase zeta isoform X7

    Conserved Domains (5) summary
    smart00045
    Location:464654
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:315436
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00204
    Location:845961
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:845871
    ANK; ANK repeat [structural motif]
    cl00040
    Location:190249
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
  2. XM_024448734.1XP_024304502.1  diacylglycerol kinase zeta isoform X8

    Conserved Domains (5) summary
    smart00045
    Location:463653
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:314435
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00204
    Location:844960
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:844870
    ANK; ANK repeat [structural motif]
    cl00040
    Location:189248
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
  3. XM_024448741.1XP_024304509.1  diacylglycerol kinase zeta isoform X15

    Related
    ENSP00000434719.1, ENST00000528615.5
    Conserved Domains (5) summary
    smart00045
    Location:327517
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:178299
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00204
    Location:708824
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:708734
    ANK; ANK repeat [structural motif]
    cl00040
    Location:53112
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
  4. XM_024448735.1XP_024304503.1  diacylglycerol kinase zeta isoform X9

    Conserved Domains (5) summary
    smart00045
    Location:452642
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:303424
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00204
    Location:833949
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:833859
    ANK; ANK repeat [structural motif]
    cl00040
    Location:178237
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
  5. XM_005253182.3XP_005253239.1  diacylglycerol kinase zeta isoform X16

    See identical proteins and their annotated locations for XP_005253239.1

    Conserved Domains (7) summary
    smart00045
    Location:452609
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:303424
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    COG1597
    Location:299622
    LCB5; Diacylglycerol kinase family enzyme [Lipid transport and metabolism, General function prediction only]
    cd00204
    Location:800916
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:800894
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:800826
    ANK; ANK repeat [structural motif]
    cl00040
    Location:178237
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
  6. XM_024448739.1XP_024304507.1  diacylglycerol kinase zeta isoform X13

    Conserved Domains (4) summary
    smart00045
    Location:429619
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:280401
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00204
    Location:810926
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:810836
    ANK; ANK repeat [structural motif]
  7. XM_024448740.1XP_024304508.1  diacylglycerol kinase zeta isoform X14

    Conserved Domains (2) summary
    smart00045
    Location:429586
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:280401
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
  8. XM_024448736.1XP_024304504.1  diacylglycerol kinase zeta isoform X10

    Conserved Domains (5) summary
    smart00045
    Location:451641
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:302423
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00204
    Location:832948
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:832858
    ANK; ANK repeat [structural motif]
    cl00040
    Location:177236
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
  9. XM_024448738.1XP_024304506.1  diacylglycerol kinase zeta isoform X12

    Conserved Domains (5) summary
    smart00045
    Location:446636
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:297418
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00204
    Location:827943
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:827853
    ANK; ANK repeat [structural motif]
    cl00040
    Location:172231
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
  10. XM_024448731.1XP_024304499.1  diacylglycerol kinase zeta isoform X3

    Conserved Domains (4) summary
    smart00045
    Location:671861
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:522643
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00204
    Location:10521168
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:10521078
    ANK; ANK repeat [structural motif]
  11. XM_024448729.1XP_024304497.1  diacylglycerol kinase zeta isoform X1

    Conserved Domains (5) summary
    smart00045
    Location:694884
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:545666
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00204
    Location:10751191
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam00130
    Location:420479
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    sd00045
    Location:10751101
    ANK; ANK repeat [structural motif]
  12. XM_024448730.1XP_024304498.1  diacylglycerol kinase zeta isoform X2

    Conserved Domains (5) summary
    smart00045
    Location:693883
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:544665
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00204
    Location:10741190
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam00130
    Location:419478
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    sd00045
    Location:10741100
    ANK; ANK repeat [structural motif]
  13. XM_024448737.1XP_024304505.1  diacylglycerol kinase zeta isoform X11

    Conserved Domains (5) summary
    smart00045
    Location:447637
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:298419
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00204
    Location:828944
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:828854
    ANK; ANK repeat [structural motif]
    cl00040
    Location:173232
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
  14. XM_017018456.1XP_016873945.1  diacylglycerol kinase zeta isoform X5

  15. XM_017018455.1XP_016873944.1  diacylglycerol kinase zeta isoform X4

  16. XM_024448732.1XP_024304500.1  diacylglycerol kinase zeta isoform X6

    Conserved Domains (5) summary
    smart00045
    Location:636826
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:487608
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00204
    Location:10171133
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam00130
    Location:362421
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    sd00045
    Location:10171043
    ANK; ANK repeat [structural motif]

RNA

  1. XR_002957206.1 RNA Sequence

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