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DGKZ diacylglycerol kinase zeta [ Homo sapiens (human) ]

Gene ID: 8525, updated on 11-Apr-2024

Summary

Official Symbol
DGKZprovided by HGNC
Official Full Name
diacylglycerol kinase zetaprovided by HGNC
Primary source
HGNC:HGNC:2857
See related
Ensembl:ENSG00000149091 MIM:601441; AllianceGenome:HGNC:2857
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DAGK5; DAGK6; DGK-ZETA; hDGKzeta
Summary
The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It may attenuate protein kinase C activity by regulating diacylglycerol levels in intracellular signaling cascade and signal transduction. Alternative splicing occurs at this locus and multiple transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Nov 2010]
Expression
Ubiquitous expression in brain (RPKM 24.7), bone marrow (RPKM 15.6) and 24 other tissues See more
Orthologs
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Genomic context

See DGKZ in Genome Data Viewer
Location:
11p11.2
Exon count:
35
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (46332926..46380554)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (46489001..46536630)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (46354476..46402104)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2489 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:46312695-46313398 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3301 Neighboring gene cAMP responsive element binding protein 3 like 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:46328063-46328758 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:46352624-46352765 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4676 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3302 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:46357769-46358498 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:46360689-46361418 Neighboring gene Sharpr-MPRA regulatory region 11965 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4678 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4679 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3303 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:46369312-46369525 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:46369839-46370824 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:46373336-46374190 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:46374191-46375045 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:46375046-46375899 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:46377222-46378090 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:46390736-46391935 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:46401950-46402584 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3306 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3307 Neighboring gene Sharpr-MPRA regulatory region 2210 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3310 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:46411613-46412218 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3309 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:46412219-46412822 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3311 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3312 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:46414340-46415114 Neighboring gene microRNA 4688 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:46428977-46429764 Neighboring gene cholinergic receptor muscarinic 4 Neighboring gene midkine Neighboring gene autophagy and beclin 1 regulator 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:46448914-46449505 Neighboring gene ribosomal protein S10 pseudogene 19

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP-dependent diacylglycerol kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ATP-dependent diacylglycerol kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ATP-dependent diacylglycerol kinase activity TAS
Traceable Author Statement
more info
 
enables alkylglycerol kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cell migration NAS
Non-traceable Author Statement
more info
PubMed 
involved_in diacylglycerol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in diacylglycerol metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in glycerolipid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in lipid phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in lipid phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of T cell receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in phosphatidic acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in phosphatidic acid biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in phosphatidic acid biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in phosphatidic acid biosynthetic process TAS
Traceable Author Statement
more info
PubMed 
involved_in platelet activation TAS
Traceable Author Statement
more info
 
involved_in protein kinase C-activating G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm TAS
Traceable Author Statement
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in lamellipodium IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nuclear speck IDA
Inferred from Direct Assay
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
diacylglycerol kinase zeta
Names
DAG kinase zeta
diacylglycerol kinase, zeta 104kDa
diglyceride kinase zeta
NP_001099010.1
NP_001186195.1
NP_001186196.1
NP_001186197.1
NP_003637.2
NP_963290.1
NP_963291.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047092.1 RefSeqGene

    Range
    19559..52647
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001105540.2NP_001099010.1  diacylglycerol kinase zeta isoform 4

    See identical proteins and their annotated locations for NP_001099010.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) encodes the longest isoform (4).
    Source sequence(s)
    AC116021, U94905
    Consensus CDS
    CCDS41640.1
    UniProtKB/TrEMBL
    Q6ZT25
    Related
    ENSP00000412178.1, ENST00000454345.6
    Conserved Domains (7) summary
    smart00045
    Location:635792
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:486607
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    COG1597
    Location:482805
    LCB5; Diacylglycerol kinase family enzyme [Lipid transport and metabolism, General function prediction only]
    cd00204
    Location:9831099
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam00130
    Location:361420
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam12796
    Location:9831077
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:9831009
    ANK; ANK repeat [structural motif]
  2. NM_001199266.2NP_001186195.1  diacylglycerol kinase zeta isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) has an alternate 5' sequence including the coding region and extra nts CAG and an extra segment at alternate splice sites, respectively, in the CDS, compared to variant 4. The resulting isoform (5) has a shorter and distinct N-terminus, and an internal additional aa and an additional segment, compared to isoform 4.
    Source sequence(s)
    AK225774, CB959911, U51477
    Consensus CDS
    CCDS55757.1
    UniProtKB/TrEMBL
    Q6ZT25
    Related
    ENSP00000436291.1, ENST00000527911.5
    Conserved Domains (7) summary
    smart00045
    Location:447604
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:298419
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    COG1597
    Location:294617
    LCB5; Diacylglycerol kinase family enzyme [Lipid transport and metabolism, General function prediction only]
    cd00204
    Location:795916
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:795894
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:795821
    ANK; ANK repeat [structural motif]
    cl00040
    Location:173232
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
  3. NM_001199267.2NP_001186196.1  diacylglycerol kinase zeta isoform 6

    See identical proteins and their annotated locations for NP_001186196.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) has an alternate 5' sequence including the coding region compared to variant 4. The resulting isoform (6) has a shorter and distinct N-terminus, compared to isoform 4.
    Source sequence(s)
    CB959911, U51477
    Consensus CDS
    CCDS55759.1
    UniProtKB/Swiss-Prot
    B7Z2M9, B7Z6M3, E9PPW4, F6UCU9, G3V0F6, J3KNJ6, O00542, Q13574, Q6ZVG7, Q8IVW9
    UniProtKB/TrEMBL
    Q6ZT25
    Related
    ENSP00000395684.2, ENST00000456247.7
    Conserved Domains (6) summary
    smart00045
    Location:446603
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:297418
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    sd00045
    Location:794820
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:794888
    Ank_2; Ankyrin repeats (3 copies)
    cd20849
    Location:88160
    C1_DGKzeta_rpt1; first protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase zeta (DAG kinase zeta) and similar proteins
    cd20895
    Location:170244
    C1_DGKzeta_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase zeta (DAG kinase zeta) and similar proteins
  4. NM_001199268.2NP_001186197.1  diacylglycerol kinase zeta isoform 7

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) has an alternate 5' sequence including the coding region and extra nts CAG at an alternate splice site in the CDS, and lacks an in-frame coding exon, compared to variant 4. The resulting isoform (7) has a shorter and distinct N-terminus and an internal additional aa, and lacks an internal segment, compared to isoform 4.
    Source sequence(s)
    AK294888, CB959911, U51477
    Consensus CDS
    CCDS55758.1
    UniProtKB/TrEMBL
    Q6ZT25
    Related
    ENSP00000320340.8, ENST00000318201.12
    Conserved Domains (6) summary
    smart00045
    Location:424581
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:275396
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    COG1597
    Location:271594
    LCB5; Diacylglycerol kinase family enzyme [Lipid transport and metabolism, General function prediction only]
    cd00204
    Location:772888
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:772866
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:772798
    ANK; ANK repeat [structural motif]
  5. NM_003646.4NP_003637.2  diacylglycerol kinase zeta isoform 2

    See identical proteins and their annotated locations for NP_003637.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an alternate 5' sequence including the coding region and extra nts CAG at an alternate splice site in the CDS, compared to variant 4. The resulting isoform (2) has a shorter and distinct N-terminus and an internal additional aa, compared to isoform 4.
    Source sequence(s)
    BU849628, CB959911, U94905
    Consensus CDS
    CCDS44580.1
    UniProtKB/TrEMBL
    Q6ZT25
    Related
    ENSP00000391021.2, ENST00000421244.6
    Conserved Domains (6) summary
    smart00045
    Location:447604
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:298419
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    sd00045
    Location:795821
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:795889
    Ank_2; Ankyrin repeats (3 copies)
    cd20849
    Location:88161
    C1_DGKzeta_rpt1; first protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase zeta (DAG kinase zeta) and similar proteins
    cd20895
    Location:171245
    C1_DGKzeta_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase zeta (DAG kinase zeta) and similar proteins
  6. NM_201532.3NP_963290.1  diacylglycerol kinase zeta isoform 1

    See identical proteins and their annotated locations for NP_963290.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) has an alternate 5' sequence including the coding region, compared to variant 4. The resulting isoform (1) has a shorter and distinct N-terminus, compared to isoform 4.
    Source sequence(s)
    AK124594
    Consensus CDS
    CCDS7918.1
    UniProtKB/TrEMBL
    Q6ZT25
    Related
    ENSP00000343065.6, ENST00000343674.10
    Conserved Domains (7) summary
    smart00045
    Location:463620
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:314435
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    COG1597
    Location:310633
    LCB5; Diacylglycerol kinase family enzyme [Lipid transport and metabolism, General function prediction only]
    cd00204
    Location:811927
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:811905
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:811837
    ANK; ANK repeat [structural motif]
    cl00040
    Location:189248
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
  7. NM_201533.3NP_963291.2  diacylglycerol kinase zeta isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has an alternate 5' sequence including the coding region, lacks nts GAG at an alternate splice site and has extra nts CAG at another alternate splice sites in the CDS, compared to variant 4. The resulting isoform (3) has a shorter and distinct N-terminus, lacks an internal aa in one region and has an additional aa in another region, compared to isoform 4.
    Source sequence(s)
    AK300577, DC416889, U51477
    Consensus CDS
    CCDS44579.2
    UniProtKB/TrEMBL
    Q6ZT25
    Related
    ENSP00000436273.2, ENST00000532868.6
    Conserved Domains (7) summary
    smart00045
    Location:451608
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:302423
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    COG1597
    Location:298621
    LCB5; Diacylglycerol kinase family enzyme [Lipid transport and metabolism, General function prediction only]
    cd00204
    Location:799915
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:799893
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:799825
    ANK; ANK repeat [structural motif]
    cl00040
    Location:177236
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    46332926..46380554
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    46489001..46536630
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)