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SEC66 Sec63 complex subunit SEC66 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852469, updated on 4-Feb-2024

Summary

Gene symbol
SEC66
Gene description
Sec63 complex subunit SEC66
Primary source
SGD:S000000375
Locus tag
YBR171W
See related
AllianceGenome:SGD:S000000375
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
HSS1; KAR7; SEC71
Summary
Contributes to protein transmembrane transporter activity. Involved in filamentous growth and posttranslational protein targeting to membrane, translocation. Located in endoplasmic reticulum membrane. Part of Sec62/Sec63 complex. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See SEC66 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (578364..578984)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene adenyl-nucleotide exchange factor SSE2 Neighboring gene nuclear protein localization protein 4 Neighboring gene Smy2p Neighboring gene Ump1p

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
contributes_to protein transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of Sec62/Sec63 complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of Sec62/Sec63 complex IEA
Inferred from Electronic Annotation
more info
 
part_of Sec62/Sec63 complex IPI
Inferred from Physical Interaction
more info
PubMed 
located_in cell periphery HDA PubMed 
located_in endoplasmic reticulum HDA PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
Sec63 complex subunit SEC66
NP_009730.3
  • Non-essential subunit of Sec63 complex; with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and translocation into the ER; other members are Sec63p, Sec62p, and Sec72p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    578364..578984
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178519.3NP_009730.3  TPA: Sec63 complex subunit SEC66 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009730.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQG7, P33754
    UniProtKB/TrEMBL
    A0A6A5Q4J8, A6ZLB4, B3LMY8, C7GUI6, D3UER6, G2W9H4, N1P9J2
    Conserved Domains (1) summary
    pfam09802
    Location:27197
    Sec66; Preprotein translocase subunit Sec66