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SSA3 Hsp70 family ATPase SSA3 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852203, updated on 4-Feb-2024

Summary

Gene symbol
SSA3
Gene description
Hsp70 family ATPase SSA3
Primary source
SGD:S000000171
Locus tag
YBL075C
See related
AllianceGenome:SGD:S000000171
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
YG106
Summary
Enables ATP hydrolysis activity and unfolded protein binding activity. Involved in SRP-dependent cotranslational protein targeting to membrane, translocation; protein folding; and protein quality control for misfolded or incompletely synthesized proteins. Located in cytosol. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; artery disease (multiple); autoimmune disease of musculoskeletal system (multiple); neurodegenerative disease (multiple); and schizophrenia (multiple). Orthologous to several human genes including HSPA1L (heat shock protein family A (Hsp70) member 1 like); HSPA1B (heat shock protein family A (Hsp70) member 1B); and HSPA8 (heat shock protein family A (Hsp70) member 8). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See SSA3 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (84499..86448, complement)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene ubiquitin-like protein ATG8 Neighboring gene isoleucine--tRNA ligase ILS1 Neighboring gene U5 snRNP complex subunit AAR2 Neighboring gene ncRNA

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ATP hydrolysis activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables ATP-dependent protein folding chaperone IEA
Inferred from Electronic Annotation
more info
 
enables heat shock protein binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein folding chaperone IBA
Inferred from Biological aspect of Ancestor
more info
 
enables unfolded protein binding IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
Hsp70 family ATPase SSA3
NP_009478.1
  • ATPase involved in protein folding and the response to stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the heat shock protein 70 (HSP70) family; localized to the cytoplasm; SSA3 has a paralog, SSA4, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    84499..86448 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178315.1NP_009478.1  TPA: Hsp70 family ATPase SSA3 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009478.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VPS7, P09435, P18862
    UniProtKB/TrEMBL
    A0A8H4BUU7, A6ZKM6, B3LNK8, C7GK58, C8Z3R8, N1P8N4
    Conserved Domains (1) summary
    PTZ00009
    Location:4649
    PTZ00009; heat shock 70 kDa protein; Provisional