BNA4 kynurenine 3-monooxygenase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: BNA4
Official Full Name: kynurenine 3-monooxygenase
Primary source: SGD:S000000194
Locus tag: YBL098W
See related: AllianceGenome:SGD:S000000194; FungiDB:YBL098W; VEuPathDB:YBL098W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables kynurenine 3-monooxygenase activity. Involved in 'de novo' NAD biosynthetic process from tryptophan. Located in mitochondrial outer membrane. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human KMO (kynurenine 3-monooxygenase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:: chromosome: II

Exon count:: 1

Sequence:: Chromosome: II; NC_001134.8 (39145..40527)

Chromosome II - NC_001134.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the first crystal structure of Saccharomyces cerevisiae KMO, in the free form and in complex with the tight-binding inhibitor UPF 648
Title: Structural basis of kynurenine 3-monooxygenase inhibition.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables FAD binding	IEA Inferred from Electronic Annotation more info
enables flavin adenine dinucleotide binding	IEA Inferred from Electronic Annotation more info
enables kynurenine 3-monooxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables kynurenine 3-monooxygenase activity	IEA Inferred from Electronic Annotation more info
enables kynurenine 3-monooxygenase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables monooxygenase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in 'de novo' NAD biosynthetic process from tryptophan	IEA Inferred from Electronic Annotation more info
involved_in 'de novo' NAD biosynthetic process from tryptophan	IGI Inferred from Genetic Interaction more info	PubMed
involved_in NAD biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in anthranilate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in kynurenine metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in pyridine nucleotide biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in quinolinate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in tryptophan catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrial membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial outer membrane	HDA more info	PubMed
is_active_in mitochondrial outer membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in peroxisome	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: kynurenine 3-monooxygenase

NP_009454.1

EC 1.14.13.9

Kynurenine 3-monooxygenase; required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p; localizes to mitochondria and peroxisomes; putative therapeutic target for Huntington disease

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001134.8 Reference assembly

Range

39145..40527

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001178338.1 → NP_009454.1 TPA: kynurenine 3-monooxygenase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_009454.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VPQ7, P38169

UniProtKB/TrEMBL

A6ZKK6, B3LNM8, B5VDP6, C7GSE7, C8Z3U6, N1P8U1

Conserved Domains (1) summary

COG0654
Location:1 → 378

UbiH; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme transport and metabolism, Energy production and conversion]