U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

BNA4 kynurenine 3-monooxygenase [ Saccharomyces cerevisiae S288C ]

Gene ID: 852179, updated on 8-Sep-2022

Summary

Gene symbol
BNA4
Gene description
kynurenine 3-monooxygenase
Primary source
SGD:S000000194
Locus tag
YBL098W
See related
AllianceGenome:SGD:S000000194
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables kynurenine 3-monooxygenase activity. Involved in 'de novo' NAD biosynthetic process from tryptophan. Located in mitochondrial outer membrane. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human KMO (kynurenine 3-monooxygenase). [provided by Alliance of Genome Resources, Apr 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See BNA4 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (39145..40527)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene tRNA-Phe Neighboring gene F1F0 ATP synthase subunit alpha Neighboring gene condensin subunit BRN1 Neighboring gene Mrx3p

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the BNA4 gene: The BNA4 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, E.gossypii, M.oryzae, N.crassa, and frog.

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables FAD binding IEA
Inferred from Electronic Annotation
more info
 
enables NAD(P)H oxidase H2O2-forming activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables flavin adenine dinucleotide binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables kynurenine 3-monooxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables kynurenine 3-monooxygenase activity IEA
Inferred from Electronic Annotation
more info
 
enables kynurenine 3-monooxygenase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables monooxygenase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in 'de novo' NAD biosynthetic process from tryptophan IEA
Inferred from Electronic Annotation
more info
 
involved_in 'de novo' NAD biosynthetic process from tryptophan IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in NAD biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in NAD metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in anthranilate metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in kynurenine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in pyridine nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in quinolinate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in tryptophan catabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial outer membrane HDA PubMed 
is_active_in mitochondrial outer membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
kynurenine 3-monooxygenase
NP_009454.1
  • Kynurenine 3-monooxygenase; required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p; putative therapeutic target for Huntington disease

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    39145..40527
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178338.1NP_009454.1  TPA: kynurenine 3-monooxygenase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009454.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VPQ7, P38169
    UniProtKB/TrEMBL
    A0A6C1DL29, A0A815W2D9, A0A8H4BSS7, B3LNM8, B5VDP6, C7GSE7, H0GC17, N1P8U1
    Conserved Domains (1) summary
    COG0654
    Location:1378
    UbiH; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme transport and metabolism, Energy production and conversion]