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GCM1 glial cells missing transcription factor 1 [ Homo sapiens (human) ]

Gene ID: 8521, updated on 23-Dec-2018

Summary

Official Symbol
GCM1provided by HGNC
Official Full Name
glial cells missing transcription factor 1provided by HGNC
Primary source
HGNC:HGNC:4197
See related
Ensembl:ENSG00000137270 MIM:603715
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GCMA; hGCMa
Summary
This gene encodes a DNA-binding protein with a gcm-motif (glial cell missing motif). The encoded protein is a homolog of the Drosophila glial cells missing gene (gcm). This protein binds to the GCM-motif (A/G)CCCGCAT, a novel sequence among known targets of DNA-binding proteins. The N-terminal DNA-binding domain confers the unique DNA-binding activity of this protein. [provided by RefSeq, Jul 2008]
Expression
Biased expression in placenta (RPKM 5.9), testis (RPKM 0.6) and 1 other tissue See more
Orthologs

Genomic context

See GCM1 in Genome Data Viewer
Location:
6p12.1
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 6 NC_000006.12 (53126961..53262803, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (52991759..53013624, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene intestinal cell kinase Neighboring gene F-box protein 9 Neighboring gene RNA, 7SL, cytoplasmic 244, pseudogene Neighboring gene RNA, U6 small nuclear 464, pseudogene Neighboring gene superoxide dismutase 1 pseudogene 1 Neighboring gene RNA, U1 small nuclear 136, pseudogene Neighboring gene high mobility group box 1 pseudogene 20 Neighboring gene ELOVL fatty acid elongase 5 Neighboring gene microRNA 5685 Neighboring gene uncharacterized LOC107986604 Neighboring gene ribosomal protein S16 pseudogene 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
transcription factor complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
chorion-specific transcription factor GCMa
Names
GCM motif protein 1
glial cells missing homolog 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003643.4NP_003634.2  chorion-specific transcription factor GCMa

    See identical proteins and their annotated locations for NP_003634.2

    Status: REVIEWED

    Source sequence(s)
    AB026493, AI219562, AL512347, BC096288, BC096289, D88613
    Consensus CDS
    CCDS4950.1
    UniProtKB/Swiss-Prot
    Q9NP62
    Related
    ENSP00000259803.7, ENST00000259803.7
    Conserved Domains (2) summary
    pfam03615
    Location:30167
    GCM; GCM motif protein
    cl25750
    Location:173237
    DamX; Cell division protein DamX, binds to the septal ring, contains C-terminal SPOR domain [Cell cycle control, cell division, chromosome partitioning]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p12 Primary Assembly

    Range
    53126961..53262803 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017011390.2XP_016866879.1  chorion-specific transcription factor GCMa isoform X1

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