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GCM1 glial cells missing transcription factor 1 [ Homo sapiens (human) ]

Gene ID: 8521, updated on 23-Jun-2022

Summary

Official Symbol
GCM1provided by HGNC
Official Full Name
glial cells missing transcription factor 1provided by HGNC
Primary source
HGNC:HGNC:4197
See related
Ensembl:ENSG00000137270 MIM:603715; AllianceGenome:HGNC:4197
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GCMA; hGCMa
Summary
This gene encodes a DNA-binding protein with a gcm-motif (glial cell missing motif). The encoded protein is a homolog of the Drosophila glial cells missing gene (gcm). This protein binds to the GCM-motif (A/G)CCCGCAT, a novel sequence among known targets of DNA-binding proteins. The N-terminal DNA-binding domain confers the unique DNA-binding activity of this protein. [provided by RefSeq, Jul 2008]
Expression
Biased expression in placenta (RPKM 5.9), testis (RPKM 0.6) and 1 other tissue See more
Orthologs
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Genomic context

See GCM1 in Genome Data Viewer
Location:
6p12.1
Exon count:
6
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (53126961..53148841, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (52966559..52988449, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (52991759..53013639, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene F-box protein 9 Neighboring gene RNA, 7SL, cytoplasmic 244, pseudogene Neighboring gene Sharpr-MPRA regulatory region 2296 Neighboring gene small nucleolar RNA U3 Neighboring gene RNA, U6 small nuclear 464, pseudogene Neighboring gene superoxide dismutase 1 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in anatomical structure morphogenesis TAS
Traceable Author Statement
more info
PubMed 
involved_in astrocyte fate commitment IEA
Inferred from Electronic Annotation
more info
 
involved_in branching involved in labyrinthine layer morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in cell differentiation involved in embryonic placenta development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in gliogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of syncytium formation by plasma membrane fusion IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of cell differentiation involved in embryonic placenta development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in syncytium formation by plasma membrane fusion IEA
Inferred from Electronic Annotation
more info
 
involved_in transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in chromatin ISA
Inferred from Sequence Alignment
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of transcription regulator complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
chorion-specific transcription factor GCMa
Names
GCM motif protein 1
glial cells missing homolog 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003643.4NP_003634.2  chorion-specific transcription factor GCMa

    See identical proteins and their annotated locations for NP_003634.2

    Status: REVIEWED

    Source sequence(s)
    AB026493, AI219562, AL512347, BC096288, BC096289, D88613
    Consensus CDS
    CCDS4950.1
    UniProtKB/Swiss-Prot
    Q9NP62
    Related
    ENSP00000259803.7, ENST00000259803.8
    Conserved Domains (2) summary
    pfam03615
    Location:30167
    GCM; GCM motif protein
    cl25750
    Location:173237
    DamX; Cell division protein DamX, binds to the septal ring, contains C-terminal SPOR domain [Cell cycle control, cell division, chromosome partitioning]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    53126961..53148841 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    52966559..52988449 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)