U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

RKM2 protein-lysine N-methyltransferase [ Saccharomyces cerevisiae S288C ]

Gene ID: 851779, updated on 18-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
RKM2
Official Full Name
protein-lysine N-methyltransferase
Primary source
SGD:S000002606
Locus tag
YDR198C
See related
AllianceGenome:SGD:S000002606; FungiDB:YDR198C; VEuPathDB:YDR198C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables protein-lysine N-methyltransferase activity. Involved in peptidyl-lysine monomethylation and peptidyl-lysine trimethylation. Orthologous to human SETD4 (SET domain containing 4). [provided by Alliance of Genome Resources, Apr 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (852533..853972, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene putative dephospho-CoA kinase Neighboring gene Cbs2p Neighboring gene Vps64p Neighboring gene Spc19p

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. A novel SET domain methyltransferase in yeast: Rkm2-dependent trimethylation of ribosomal protein L12ab at lysine 10. Porras-Yakushi TR, et al. J Biol Chem, 2006 Nov 24. PMID 17005568
  2. Identification of two SET domain proteins required for methylation of lysine residues in yeast ribosomal protein Rpl42ab. Webb KJ, et al. J Biol Chem, 2008 Dec 19. PMID 18957409, Free PMC Article
  3. Ribosomal protein methyltransferases in the yeast Saccharomyces cerevisiae: Roles in ribosome biogenesis and translation. Al-Hadid Q, et al. Biochem Biophys Res Commun, 2016 Feb 12. PMID 26801560, Free PMC Article
  4. Significant conservation of synthetic lethal genetic interaction networks between distantly related eukaryotes. Dixon SJ, et al. Proc Natl Acad Sci U S A, 2008 Oct 28. PMID 18931302, Free PMC Article
  5. Genetic Networks Required to Coordinate Chromosome Replication by DNA Polymerases α, δ, and ε in Saccharomyces cerevisiae. Dubarry M, et al. G3 (Bethesda), 2015 Aug 21. PMID 26297725, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Rkm2 has a role in trimethylation of ribosomal protein L12ab at lysine 10
    Title: A novel SET domain methyltransferase in yeast: Rkm2-dependent trimethylation of ribosomal protein L12ab at lysine 10.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein-lysine N-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-lysine N-methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein-lysine N-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in peptidyl-lysine monomethylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in peptidyl-lysine trimethylation IEA
Inferred from Electronic Annotation
more info
  
involved_in peptidyl-lysine trimethylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

Go to the top of the page Help
Preferred Names
protein-lysine N-methyltransferase
NP_010484.1
  • Ribosomal protein lysine methyltransferase; responsible for trimethylation of the lysine residue at position 3 of Rpl12Ap and Rpl12Bp

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    852533..853972 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180506.1 → NP_010484.1  TPA: protein-lysine N-methyltransferase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010484.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VSI1, Q03942
    UniProtKB/TrEMBL
    A6ZYF7, B3LG85, B5VG91, C7GMZ9, N1P6U0
    Conserved Domains (1) summary
    cd19177
    Location:20 → 340
    SET_SETD4; SET domain found in SET domain-containing protein 4 (SETD4) and similar proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q03942.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools
Miscellaneous