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TRS85 Trs85p [ Saccharomyces cerevisiae S288C ]

Gene ID: 851686, updated on 2-Nov-2024

Summary

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Official Symbol
TRS85
Official Full Name
Trs85p
Primary source
SGD:S000002515
Locus tag
YDR108W
See related
AllianceGenome:SGD:S000002515; FungiDB:YDR108W; VEuPathDB:YDR108W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
GSG1; MUM1
Summary
Involved in several processes, including Cvt vesicle assembly; endoplasmic reticulum to Golgi vesicle-mediated transport; and macroautophagy. Located in Golgi apparatus; cytoplasmic vesicle; and phagophore assembly site. Part of TRAPPIII protein complex. Orthologous to human TRAPPC8 (trafficking protein particle complex subunit 8). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See TRS85 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (671269..673365)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene tRNA-Ile Neighboring gene Tmn2p Neighboring gene putative phosphotransferase Neighboring gene replication fork barrier binding protein FOB1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. GSG1, a yeast gene required for sporulation. Kaytor MD, et al. Yeast, 1995 Sep 30. PMID 8619313
  2. Trs85 is required for macroautophagy, pexophagy and cytoplasm to vacuole targeting in Yarrowia lipolytica and Saccharomyces cerevisiae. Nazarko TY, et al. Autophagy, 2005 Apr. PMID 16874038, Free PMC Article
  3. Trs85 (Gsg1), a component of the TRAPP complexes, is required for the organization of the preautophagosomal structure during selective autophagy via the Cvt pathway. Meiling-Wesse K, et al. J Biol Chem, 2005 Sep 30. PMID 16079147
  4. Regulation of selective autophagy onset by a Ypt/Rab GTPase module. Lipatova Z, et al. Proc Natl Acad Sci U S A, 2012 May 1. PMID 22509044, Free PMC Article
  5. Regulation of ER-phagy by a Ypt/Rab GTPase module. Lipatova Z, et al. Mol Biol Cell, 2013 Oct. PMID 23924895, Free PMC Article

See all (92) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TRAPPIII(trs85) is responsible for vesicular transport from early endosomes to Golgi, facilitating Atg9 cycling in autophagy.
    Title: TRAPPIII is responsible for vesicular transport from early endosomes to Golgi, facilitating Atg9 cycling in autophagy.
  2. Trs85 and Ypt1 are localized to the preautophagosomal structure in an Atg9-dependent manner.
    Title: Atg9 vesicles recruit vesicle-tethering proteins Trs85 and Ypt1 to the autophagosome formation site.
  3. Trs85 directs a Ypt1 GEF, TRAPPIII, to the phagophore to promote autophagy.
    Title: Trs85 directs a Ypt1 GEF, TRAPPIII, to the phagophore to promote autophagy.
  4. Trs85 is required for nonspecific autophagy, pexophagy and the cytoplasm to vacuole targeting pathway.
    Title: Trs85 is required for macroautophagy, pexophagy and cytoplasm to vacuole targeting in Yarrowia lipolytica and Saccharomyces cerevisiae.
  5. TRS85 (GSG1)is required for the organization of the preautophagosomal structure during selective autophagy via the Cvt pathway.
    Title: Trs85 (Gsg1), a component of the TRAPP complexes, is required for the organization of the preautophagosomal structure during selective autophagy via the Cvt pathway.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in Cvt vesicle assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in autophagosome assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in autophagy IEA
Inferred from Electronic Annotation
more info
  
involved_in cytoplasm to vacuole targeting by the Cvt pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in macroautophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in meiotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pexophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in piecemeal microautophagy of the nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to phagophore assembly site IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein localization to phagophore assembly site IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sporulation resulting in formation of a cellular spore IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of TRAPPIII protein complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol HDA PubMed 
located_in phagophore assembly site IDA
Inferred from Direct Assay
more info
 PubMed 
located_in phagophore assembly site IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Trs85p
NP_010393.3
  • Component of transport protein particle (TRAPP) complex III; TRAPPIII is a multimeric guanine nucleotide-exchange factor for the GTPase Ypt1p, regulating endosome-Golgi traffic and required for membrane expansion during autophagy and the CVT pathway; directs Ypt1p to the PAS; late post-replication meiotic role

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    671269..673365
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180416.3 → NP_010393.3  TPA: Trs85p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010393.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VS94, P46944, Q04563
    UniProtKB/TrEMBL
    B3LGG7, C8Z524
    Conserved Domains (1) summary
    pfam12739
    Location:225 → 666
    TRAPPC-Trs85; ER-Golgi trafficking TRAPP I complex 85 kDa subunit
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P46944.2

Gene LinkOut

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