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SOR2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851351, updated on 22-Aug-2024

Summary

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Official Symbol
SOR2
Primary source
FungiDB:YDL246C
Locus tag
YDL246C
See related
SGD:S000002405; AllianceGenome:SGD:S000002405; VEuPathDB:YDL246C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables L-iditol 2-dehydrogenase activity. Predicted to be involved in hexose metabolic process and sorbitol catabolic process. Orthologous to human SORD (sorbitol dehydrogenase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (8683..9756, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Cos7p Neighboring gene alpha-glucoside permease Neighboring gene hexose transporter HXT15 Neighboring gene 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Improving xylitol yield by deletion of endogenous xylitol-assimilating genes: a study of industrial Saccharomyces cerevisiae in fermentation of glucose and xylose. Yang BX, et al. FEMS Yeast Res, 2020 Dec 16. PMID 33201998
  2. Characterization of a (2R,3R)-2,3-butanediol dehydrogenase as the Saccharomyces cerevisiae YAL060W gene product. Disruption and induction of the gene. González E, et al. J Biol Chem, 2000 Nov 17. PMID 10938079
  3. A Chemogenomic Screen Reveals Novel Snf1p/AMPK Independent Regulators of Acetyl-CoA Carboxylase. Bozaquel-Morais BL, et al. PLoS One, 2017. PMID 28076367, Free PMC Article
  4. Hxt13, Hxt15, Hxt16 and Hxt17 from Saccharomyces cerevisiae represent a novel type of polyol transporters. Jordan P, et al. Sci Rep, 2016 Mar 21. PMID 26996892, Free PMC Article
  5. Bulk segregant analysis by high-throughput sequencing reveals a novel xylose utilization gene from Saccharomyces cerevisiae. Wenger JW, et al. PLoS Genet, 2010 May 13. PMID 20485559, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables D-xylulose reductase activity IEA
Inferred from Electronic Annotation
more info
  
enables L-iditol 2-dehydrogenase (NAD+) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables L-iditol 2-dehydrogenase (NAD+) activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in hexose metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in sorbitol catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
L-iditol 2-dehydrogenase SOR2
NP_010035.1
  • Sorbitol dehydrogenase; protein sequence is 99% identical to the Sor1p sorbitol dehydrogenase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    8683..9756 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180306.1 → NP_010035.1  TPA: L-iditol 2-dehydrogenase SOR2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010035.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VRB1, Q07786
    UniProtKB/TrEMBL
    A6ZX89, C8Z6M7, N1PAA8
    Conserved Domains (1) summary
    cd05285
    Location:8 → 353
    sorbitol_DH; Sorbitol dehydrogenase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q07786.1

Gene LinkOut

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