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SED5 [ Saccharomyces cerevisiae S288C ]

Gene ID: 850713, updated on 22-Aug-2024

Summary

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Official Symbol
SED5
Primary source
FungiDB:YLR026C
Locus tag
YLR026C
See related
SGD:S000004016; AllianceGenome:SGD:S000004016; VEuPathDB:YLR026C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables SNAP receptor activity. Involved in Golgi vesicle transport and regulation of inclusion body assembly. Located in cis-Golgi network. Is integral component of membrane. Part of SNARE complex. Orthologous to human STX5 (syntaxin 5). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (195450..196472, complement)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene putative ubiquitin-protein ligase UBR2 Neighboring gene ESCRT-III subunit protein SNF7 Neighboring gene aspartate transaminase AAT2 Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The SM protein Sly1 accelerates assembly of the ER-Golgi SNARE complex. Demircioglu FE, et al. Proc Natl Acad Sci U S A, 2014 Sep 23. PMID 25189771, Free PMC Article
  2. Structural basis for the Golgi membrane recruitment of Sly1p by Sed5p. Bracher A, et al. EMBO J, 2002 Nov 15. PMID 12426383, Free PMC Article
  3. Protein-protein interactions of the yeast Golgi t-SNARE Sed5 protein distinct from its neural plasma membrane cognate syntaxin 1. Kosodo Y, et al. Biochem Biophys Res Commun, 1998 Sep 18. PMID 9753609
  4. Localization of Sed5, a putative vesicle targeting molecule, to the cis-Golgi network involves both its transmembrane and cytoplasmic domains. Banfield DK, et al. J Cell Biol, 1994 Oct. PMID 7929581, Free PMC Article
  5. SED5 encodes a 39-kD integral membrane protein required for vesicular transport between the ER and the Golgi complex. Hardwick KG, et al. J Cell Biol, 1992 Nov. PMID 1400588, Free PMC Article

See all (107) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Syntaxin 5-dependent phosphorylation of the small heat shock protein Hsp42 and its role in protein quality control.
    Title: Syntaxin 5-dependent phosphorylation of the small heat shock protein Hsp42 and its role in protein quality control.
  2. Our data suggest that Sed5 plays a novel role in autophagy, by regulating the formation of Atg9-containing vesicles in the Golgi apparatus, and the genetic interaction between Sft1/2 and Sed5 is essential for autophagy.
    Title: The Roles of the SNARE Protein Sed5 in Autophagy in Saccharomyces cerevisiae.
  3. Data show that Sed5 binds SLY1 but its stability is not influenced by Sly1 interaction.
    Title: SM-protein-controlled ER-associated degradation discriminates between different SNAREs.
  4. only Sed5p was depleted in vesicles made with Sec24p A-site mutants
    Title: ER-Golgi transport defects are associated with mutations in the Sed5p-binding domain of the COPII coat subunit, Sec24p.
  5. A cycle of Sed5 phosphorylation and dephosphorylation is required for normal t-SNARE function and may choreograph Golgi ordering and dispersal.
    Title: Control of Golgi morphology and function by Sed5 t-SNARE phosphorylation.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables SNAP receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables SNAP receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables SNAP receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intra-Golgi vesicle-mediated transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of inclusion body assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in vesicle docking IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle fusion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle fusion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in vesicle fusion with Golgi apparatus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
part_of SNARE complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SNARE complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cis-Golgi network IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
t-SNARE syntaxin
NP_013126.1
  • cis-Golgi t-SNARE syntaxin; required for vesicular transport between the ER and the Golgi complex; binds at least 9 SNARE proteins; plays a role in autophagy by regulating formation of autophagic vesicles in Golgi

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    195450..196472 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181913.1 → NP_013126.1  TPA: t-SNARE syntaxin [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013126.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VY28, Q01590
    UniProtKB/TrEMBL
    A7A0T2, B3LSZ9, B5VMW4, C7GXH2, C8ZCZ8, N1P027
    Conserved Domains (1) summary
    cd15844
    Location:252 → 324
    SNARE_syntaxin5; SNARE motif of syntaxin 5
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q01590.1

Gene LinkOut

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