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KEG1 Keg1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 850603, updated on 17-May-2024

Summary

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Gene symbol
KEG1
Gene description
Keg1p
Primary source
FungiDB:YFR042W
Locus tag
YFR042W
See related
SGD:S000001938; AllianceGenome:SGD:S000001938; VEuPathDB:YFR042W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in (1->6)-beta-D-glucan biosynthetic process and chromosome organization. Is integral component of endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See KEG1 in Genome Data Viewer
Location:
chromosome: VI
Exon count:
1
Sequence:
Chromosome: VI; NC_001138.5 (238458..239060)

Chromosome VI - NC_001138.5Genomic Context describing neighboring genes Neighboring gene Sap155p Neighboring gene Erj5p Neighboring gene Irc6p Neighboring gene metallodipeptidase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001138.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. KEG1/YFR042w encodes a novel Kre6-binding endoplasmic reticulum membrane protein responsible for beta-1,6-glucan synthesis in Saccharomyces cerevisiae. Nakamata K, et al. J Biol Chem, 2007 Nov 23. PMID 17893149
  2. Action of multiple endoplasmic reticulum chaperon-like proteins is required for proper folding and polarized localization of Kre6 protein essential in yeast cell wall β-1,6-glucan synthesis. Kurita T, et al. J Biol Chem, 2012 May 18. PMID 22447934, Free PMC Article
  3. Toward a comprehensive temperature-sensitive mutant repository of the essential genes of Saccharomyces cerevisiae. Ben-Aroya S, et al. Mol Cell, 2008 Apr 25. PMID 18439903, Free PMC Article
  4. Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae. Murakami Y, et al. Nat Genet, 1995 Jul. PMID 7670463
  5. Functional profiling of the Saccharomyces cerevisiae genome. Giaever G, et al. Nature, 2002 Jul 25. PMID 12140549

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Keg1 and Kre6 have a cooperative role in beta-1,6-glucan synthesis in S. cerevisiae.
    Title: KEG1/YFR042w encodes a novel Kre6-binding endoplasmic reticulum membrane protein responsible for beta-1,6-glucan synthesis in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in (1->6)-beta-D-glucan biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell wall organization IEA
Inferred from Electronic Annotation
more info
  
involved_in chromosome organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum HDA PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Keg1p
NP_116700.1
  • Integral membrane protein of the ER; physically interacts with Kre6p; has a role in the synthesis of beta-1,6-glucan in the cell wall; required for cell viability

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001138.5 Reference assembly

    Range
    238458..239060
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180007.1 → NP_116700.1  TPA: Keg1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_116700.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A5A8M3, D6VTS5, P43614
    UniProtKB/TrEMBL
    A0A6A5PWV4, G2WDI3, N1P2Z5
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P43614.1

Gene LinkOut

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