U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ERJ5 Erj5p [ Saccharomyces cerevisiae S288C ]

Gene ID: 850602, updated on 18-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
ERJ5
Official Full Name
Erj5p
Primary source
SGD:S000001937
Locus tag
YFR041C
See related
AllianceGenome:SGD:S000001937; FungiDB:YFR041C; VEuPathDB:YFR041C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in protein folding. Located in endoplasmic reticulum. Orthologous to human DNAJC1 (DnaJ heat shock protein family (Hsp40) member C1). [provided by Alliance of Genome Resources, Apr 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: VI
Exon count:
1
Sequence:
Chromosome: VI; NC_001138.5 (237368..238255, complement)

Chromosome VI - NC_001138.5Genomic Context describing neighboring genes Neighboring gene Osw7p Neighboring gene Sap155p Neighboring gene Keg1p Neighboring gene Irc6p

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001138.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The Saccharomyces cerevisiae YFR041C/ERJ5 gene encoding a type I membrane protein with a J domain is required to preserve the folding capacity of the endoplasmic reticulum. Carla Famá M, et al. Biochim Biophys Acta, 2007 Feb. PMID 17157937, Free PMC Article
  2. The Hsp70 co-chaperone Ydj1/HDJ2 regulates ribonucleotide reductase activity. Sluder IT, et al. PLoS Genet, 2018 Nov. PMID 30452489, Free PMC Article
  3. Mechanisms by which PE21, an extract from the white willow Salix alba, delays chronological aging in budding yeast. Medkour Y, et al. Oncotarget, 2019 Oct 8. PMID 31645900, Free PMC Article
  4. Ltc1 is an ER-localized sterol transporter and a component of ER-mitochondria and ER-vacuole contacts. Murley A, et al. J Cell Biol, 2015 May 25. PMID 25987606, Free PMC Article
  5. Systems analysis of the genetic interaction network of yeast molecular chaperones. Rizzolo K, et al. Mol Omics, 2018 Apr 16. PMID 29659649

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Loss of the non-essential ERJ5 gene leads to a constitutively induced unfolded protein response, indicating that ERJ5 is required for maintenance of an optimal folding environment in the yeast endoplasmic reticulum.
    Title: The Saccharomyces cerevisiae YFR041C/ERJ5 gene encoding a type I membrane protein with a J domain is required to preserve the folding capacity of the endoplasmic reticulum.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein folding IEA
Inferred from Electronic Annotation
more info
  
involved_in protein folding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum HDA PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Erj5p
NP_116699.3
  • Type I membrane protein with a J domain; required to preserve the folding capacity of the endoplasmic reticulum; loss of the non-essential ERJ5 gene leads to a constitutively induced unfolded protein response

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001138.5 Reference assembly

    Range
    237368..238255 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180006.3 → NP_116699.3  TPA: Erj5p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_116699.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VTS4, P43613
    UniProtKB/TrEMBL
    A7A281, B3LUQ2, B5VI66, C7GYE5, C8Z7X6, G2WDI2, N1P4R8
    Conserved Domains (2) summary
    COG2214
    Location:41 → 271
    CbpA; Curved DNA-binding protein CbpA, contains a DnaJ-like domain [Transcription]
    pfam00226
    Location:44 → 105
    DnaJ; DnaJ domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P43613.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools