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putative Xaa-Pro dipeptidase [ Saccharomyces cerevisiae S288C ]

Gene ID: 850556, updated on 18-Sep-2024

Summary

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Official Full Name
putative Xaa-Pro dipeptidase
Primary source
SGD:S000001902
Locus tag
YFR006W
See related
AllianceGenome:SGD:S000001902; FungiDB:YFR006W; VEuPathDB:YFR006W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable peptidase activity. Predicted to be involved in proteolysis. Located in cytoplasm. Human ortholog(s) of this gene implicated in prolidase deficiency. Orthologous to human PEPD (peptidase D). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: VI
Exon count:
1
Sequence:
Chromosome: VI; NC_001138.5 (156145..157752)

Chromosome VI - NC_001138.5Genomic Context describing neighboring genes Neighboring gene proteasome regulatory particle lid subunit RPN11 Neighboring gene mRNA splicing protein SAD1 Neighboring gene tRNA-Phe Neighboring gene Yfh7p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001138.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The COG database: a tool for genome-scale analysis of protein functions and evolution. Tatusov RL, et al. Nucleic Acids Res, 2000 Jan 1. PMID 10592175, Free PMC Article
  2. APEX2-mediated proximity labeling resolves protein networks in Saccharomyces cerevisiae cells. Singer-Krüger B, et al. FEBS J, 2020 Jan. PMID 31323700
  3. Analysis of the vacuolar luminal proteome of Saccharomyces cerevisiae. Sarry JE, et al. FEBS J, 2007 Aug. PMID 17651441
  4. Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae. Murakami Y, et al. Nat Genet, 1995 Jul. PMID 7670463
  5. A Network of Conserved Synthetic Lethal Interactions for Exploration of Precision Cancer Therapy. Srivas R, et al. Mol Cell, 2016 Aug 4. PMID 27453043, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables manganese ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metalloaminopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables peptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
putative Xaa-Pro dipeptidase
NP_116661.1
  • Putative X-Pro aminopeptidase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YFR006W is not an essential gene

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001138.5 Reference assembly

    Range
    156145..157752
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179971.1 → NP_116661.1  TPA: putative Xaa-Pro dipeptidase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_116661.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VTN6, P43590, Q66RB5
    UniProtKB/TrEMBL
    B5VI32, C7GYB2, C8Z7T9, G2WDE5
    Conserved Domains (2) summary
    smart01011
    Location:72 → 192
    AMP_N; Aminopeptidase P, N-terminal domain
    cd01087
    Location:237 → 508
    Prolidase; E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-Pro.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P43590.1

Gene LinkOut

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