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GYP8 GTPase-activating protein GYP8 [ Saccharomyces cerevisiae S288C ]

Gene ID: 850517, updated on 18-Sep-2024

Summary

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Official Symbol
GYP8
Official Full Name
GTPase-activating protein GYP8
Primary source
SGD:S000001867
Locus tag
YFL027C
See related
AllianceGenome:SGD:S000001867; FungiDB:YFL027C; VEuPathDB:YFL027C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables GTPase activator activity. Involved in vesicle-mediated transport. Located in cytoplasm. Human ortholog(s) of this gene implicated in Warburg micro syndrome 4. Orthologous to human TBC1D20 (TBC1 domain family member 20). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: VI
Exon count:
1
Sequence:
Chromosome: VI; NC_001138.5 (80419..81912, complement)

Chromosome VI - NC_001138.5Genomic Context describing neighboring genes Neighboring gene cyclin-dependent protein kinase-activating kinase CAK1 Neighboring gene putative ATP-binding cassette family ATPase CAF16 Neighboring gene alpha-factor pheromone receptor STE2 Neighboring gene Bst1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001138.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A Rab GAP cascade defines the boundary between two Rab GTPases on the secretory pathway. Rivera-Molina FE, et al. Proc Natl Acad Sci U S A, 2009 Aug 25. PMID 19666511, Free PMC Article
  2. Significance of GTP hydrolysis in Ypt1p-regulated endoplasmic reticulum to Golgi transport revealed by the analysis of two novel Ypt1-GAPs. De Antoni A, et al. J Biol Chem, 2002 Oct 25. PMID 12189143
  3. Analysis of subcellular localization and function of the yeast Rab6 homologue, Ypt6p, using a novel amino-terminal tagging strategy. Kawamura S, et al. Biochem Biophys Res Commun, 2014 Jul 18. PMID 24924636
  4. Yeast reveals similar molecular mechanisms underlying alpha- and beta-synuclein toxicity. Tenreiro S, et al. Hum Mol Genet, 2016 Jan 15. PMID 26586132
  5. The Msb3/Gyp3 GAP controls the activity of the Rab GTPases Vps21 and Ypt7 at endosomes and vacuoles. Lachmann J, et al. Mol Biol Cell, 2012 Jul. PMID 22593206, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
  
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
involved_in vesicle-mediated transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in peroxisome IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
GTPase-activating protein GYP8
NP_444296.1
  • GTPase-activating protein for yeast Rab family members; Ypt1p is the preferred in vitro substrate but also acts on Sec4p, Ypt31p and Ypt32p; involved in the regulation of ER to Golgi vesicle transport; localizes to the ER and peroxisomes

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001138.5 Reference assembly

    Range
    80419..81912 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179939.1 → NP_444296.1  TPA: GTPase-activating protein GYP8 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_444296.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VTK3, P43570
    UniProtKB/TrEMBL
    C7GY84, G2WDB4, N1P4L0
    Conserved Domains (1) summary
    COG5210
    Location:2 → 497
    COG5210; GTPase-activating protein [General function prediction only]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P43570.1

Gene LinkOut

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