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TMEM241 transmembrane protein 241 [ Homo sapiens (human) ]

Gene ID: 85019, updated on 22-Sep-2022

Summary

Official Symbol
TMEM241provided by HGNC
Official Full Name
transmembrane protein 241provided by HGNC
Primary source
HGNC:HGNC:31723
See related
Ensembl:ENSG00000134490 MIM:615430; AllianceGenome:HGNC:31723
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
hVVT; SLC35D4; C18orf45
Summary
Predicted to enable antiporter activity. Predicted to be involved in carbohydrate transport and transmembrane transport. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See TMEM241 in Genome Data Viewer
Location:
18q11.2
Exon count:
21
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (23238522..23437961, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (23490110..23632036, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (20875977..21017925, complement)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 2761 Neighboring gene uncharacterized LOC124904266 Neighboring gene Cdk5 and Abl enzyme substrate 1 Neighboring gene RIO kinase 3 Neighboring gene regulator of MON1-CCZ1 Neighboring gene NPC intracellular cholesterol transporter 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

EBI GWAS Catalog

Description
Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ44259, MGC11386, MGC138577

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables antiporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
transmembrane protein 241
Names
putative vertebrate vrg4-like nucleotide-sugar transporter truncated variant2
putative vertebrate vrg4-like nucleotide-sugar transporter variant1
solute carrier family 35 member D4
transmembrane protein C18orf45

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001318834.2NP_001305763.1  transmembrane protein 241 isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) includes an alternate exon which results in the use of an alternate start codon, compared to variant 1. The encoded isoform (2) has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AB253739, AK294916, BC054507, DA385968
    UniProtKB/TrEMBL
    B4DH40, F5GXY7, Q7L033
  2. NM_032933.6NP_116322.3  transmembrane protein 241 isoform 1

    See identical proteins and their annotated locations for NP_116322.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK126247, BC054507, BC114510, BC114561
    Consensus CDS
    CCDS11876.2
    UniProtKB/Swiss-Prot
    Q24JQ0, Q6ZW41
    UniProtKB/TrEMBL
    Q7L033
    Related
    ENSP00000372720.3, ENST00000383233.8
    Conserved Domains (1) summary
    COG5070
    Location:10193
    VRG4; Nucleotide-sugar transporter [Carbohydrate transport and metabolism / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]

RNA

  1. NR_134875.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK126247, AK294916, BC054507, DA385968
    Related
    ENST00000473688.5
  2. NR_134876.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks several internal exons and contains one alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC011731, AK123623, BC006280, DA385968
    Related
    ENST00000477053.5
  3. NR_134877.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK294916, AK303553, BC054507, DA385968
  4. NR_148382.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks an internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC011731, AC026634, BC082984
  5. NR_148383.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) lacks an internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC011731, AC026634, BC082984
  6. NR_148384.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) lacks an internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC011731, AC026634, BC082984
  7. NR_148385.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) lacks an internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC011731, AC026634, BC082984

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

    Range
    23238522..23437961 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047437896.1XP_047293852.1  transmembrane protein 241 isoform X7

  2. XM_047437894.1XP_047293850.1  transmembrane protein 241 isoform X5

  3. XM_047437900.1XP_047293856.1  transmembrane protein 241 isoform X12

  4. XM_047437899.1XP_047293855.1  transmembrane protein 241 isoform X11

  5. XM_047437897.1XP_047293853.1  transmembrane protein 241 isoform X8

  6. XM_017026045.2XP_016881534.1  transmembrane protein 241 isoform X9

  7. XM_047437898.1XP_047293854.1  transmembrane protein 241 isoform X10

  8. XM_047437895.1XP_047293851.1  transmembrane protein 241 isoform X6

  9. XM_047437892.1XP_047293848.1  transmembrane protein 241 isoform X3

  10. XM_047437891.1XP_047293847.1  transmembrane protein 241 isoform X1

  11. XM_047437893.1XP_047293849.1  transmembrane protein 241 isoform X4

  12. XM_011526233.3XP_011524535.1  transmembrane protein 241 isoform X2

    Conserved Domains (1) summary
    COG5070
    Location:10193
    VRG4; Nucleotide-sugar transporter [Carbohydrate transport and metabolism / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]

RNA

  1. XR_001753290.3 RNA Sequence

  2. XR_001753288.2 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060942.1 Alternate T2T-CHM13v2.0

    Range
    23490110..23632036 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)