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TMEM241 transmembrane protein 241 [ Homo sapiens (human) ]

Gene ID: 85019, updated on 23-Nov-2021

Summary

Official Symbol
TMEM241provided by HGNC
Official Full Name
transmembrane protein 241provided by HGNC
Primary source
HGNC:HGNC:31723
See related
Ensembl:ENSG00000134490 MIM:615430
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
hVVT; C18orf45
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See TMEM241 in Genome Data Viewer
Location:
18q11.2
Exon count:
23
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 18 NC_000018.10 (23237252..23437969, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (20875977..21017925, complement)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene RB binding protein 8, endonuclease Neighboring gene RNA, 7SL, cytoplasmic 745, pseudogene Neighboring gene Sharpr-MPRA regulatory region 2761 Neighboring gene Cdk5 and Abl enzyme substrate 1 Neighboring gene RIO kinase 3 Neighboring gene regulator of MON1-CCZ1 Neighboring gene NPC intracellular cholesterol transporter 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

Associated conditions

Description Tests
Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ44259, MGC11386, MGC138577

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables antiporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
transmembrane protein 241
Names
putative vertebrate vrg4-like nucleotide-sugar transporter truncated variant2
putative vertebrate vrg4-like nucleotide-sugar transporter variant1
transmembrane protein C18orf45

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001318834.2NP_001305763.1  transmembrane protein 241 isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) includes an alternate exon which results in the use of an alternate start codon, compared to variant 1. The encoded isoform (2) has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AB253739, AK294916, BC054507, DA385968
    UniProtKB/TrEMBL
    B4DH40, F5GXY7, Q7L033
  2. NM_032933.6NP_116322.3  transmembrane protein 241 isoform 1

    See identical proteins and their annotated locations for NP_116322.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK126247, BC054507, BC114510, BC114561
    Consensus CDS
    CCDS11876.2
    UniProtKB/Swiss-Prot
    Q24JQ0
    UniProtKB/TrEMBL
    Q7L033
    Related
    ENSP00000372720.3, ENST00000383233.8
    Conserved Domains (1) summary
    COG5070
    Location:10193
    VRG4; Nucleotide-sugar transporter [Carbohydrate transport and metabolism / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]

RNA

  1. NR_134875.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK126247, AK294916, BC054507, DA385968
    Related
    ENST00000473688.5
  2. NR_134876.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks several internal exons and contains one alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC011731, AK123623, BC006280, DA385968
    Related
    ENST00000477053.5
  3. NR_134877.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK294916, AK303553, BC054507, DA385968
  4. NR_148382.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks an internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC011731, AC026634, BC082984
  5. NR_148383.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) lacks an internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC011731, AC026634, BC082984
  6. NR_148384.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) lacks an internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC011731, AC026634, BC082984
  7. NR_148385.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) lacks an internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC011731, AC026634, BC082984

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p13 Primary Assembly

    Range
    23237252..23437969 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017026043.1XP_016881532.1  transmembrane protein 241 isoform X1

  2. XM_024451277.1XP_024307045.1  transmembrane protein 241 isoform X5

  3. XM_017026046.1XP_016881535.1  transmembrane protein 241 isoform X5

  4. XM_017026047.1XP_016881536.1  transmembrane protein 241 isoform X5

  5. XM_017026048.1XP_016881537.1  transmembrane protein 241 isoform X6

  6. XM_017026045.1XP_016881534.1  transmembrane protein 241 isoform X4

  7. XM_011526233.2XP_011524535.1  transmembrane protein 241 isoform X3

    Conserved Domains (1) summary
    COG5070
    Location:10193
    VRG4; Nucleotide-sugar transporter [Carbohydrate transport and metabolism / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]
  8. XM_017026049.1XP_016881538.1  transmembrane protein 241 isoform X7

  9. XM_017026050.1XP_016881539.1  transmembrane protein 241 isoform X7

  10. XM_017026051.1XP_016881540.1  transmembrane protein 241 isoform X7

  11. XM_017026044.2XP_016881533.1  transmembrane protein 241 isoform X2

RNA

  1. XR_001753291.1 RNA Sequence

  2. XR_001753289.1 RNA Sequence

  3. XR_001753288.1 RNA Sequence

  4. XR_001753287.1 RNA Sequence

  5. XR_001753290.2 RNA Sequence

  6. XR_001753293.1 RNA Sequence

  7. XR_001753292.2 RNA Sequence

  8. XR_935260.1 RNA Sequence

    Related
    ENST00000578520.5
  9. XR_935259.1 RNA Sequence

  10. XR_001753294.1 RNA Sequence

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