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RERG RAS like estrogen regulated growth inhibitor [ Homo sapiens (human) ]

Gene ID: 85004, updated on 13-Mar-2020

Summary

Official Symbol
RERGprovided by HGNC
Official Full Name
RAS like estrogen regulated growth inhibitorprovided by HGNC
Primary source
HGNC:HGNC:15980
See related
Ensembl:ENSG00000134533 MIM:612664
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
RERG, a member of the RAS superfamily of GTPases, inhibits cell proliferation and tumor formation (Finlin et al., 2001 [PubMed 11533059]).[supplied by OMIM, Mar 2009]
Expression
Broad expression in endometrium (RPKM 41.3), adrenal (RPKM 21.0) and 16 other tissues See more
Orthologs

Genomic context

See RERG in Genome Data Viewer
Location:
12p12.3
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (15107783..15221417, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (15260716..15374411, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369670 Neighboring gene long intergenic non-protein coding RNA 1489 Neighboring gene phosphodiesterase 6H Neighboring gene uncharacterized LOC107984506 Neighboring gene RERG antisense RNA 1 Neighboring gene methyltransferase like 8 pseudogene 1 Neighboring gene uncharacterized LOC105369673 Neighboring gene protein tyrosine phosphatase receptor type O

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC15754

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GDP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GDP binding TAS
Traceable Author Statement
more info
PubMed 
GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
estrogen receptor binding NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
Ras protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of cell growth IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
response to hormone IDA
Inferred from Direct Assay
more info
PubMed 
small GTPase mediated signal transduction NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ras-related and estrogen-regulated growth inhibitor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001190726.2NP_001177655.1  ras-related and estrogen-regulated growth inhibitor isoform 2

    See identical proteins and their annotated locations for NP_001177655.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AK295343, BC007997
    Consensus CDS
    CCDS53753.1
    UniProtKB/Swiss-Prot
    Q96A58
    Related
    ENSP00000444485.1, ENST00000546331.5
    Conserved Domains (1) summary
    cl21455
    Location:8150
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  2. NM_032918.3NP_116307.1  ras-related and estrogen-regulated growth inhibitor isoform 1

    See identical proteins and their annotated locations for NP_116307.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC007997, DC331754
    Consensus CDS
    CCDS8673.1
    UniProtKB/Swiss-Prot
    Q96A58
    UniProtKB/TrEMBL
    A0A024RAT4
    Related
    ENSP00000256953.2, ENST00000256953.6
    Conserved Domains (1) summary
    cd04146
    Location:8169
    RERG_RasL11_like; Ras-related and Estrogen-Regulated Growth inhibitor (RERG) and Ras-like 11 (RasL11)-like families

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    15107783..15221417 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017020121.2XP_016875610.1  ras-related and estrogen-regulated growth inhibitor isoform X1

    Conserved Domains (2) summary
    cd04146
    Location:19166
    RERG_RasL11_like; Ras-related and Estrogen-Regulated Growth inhibitor (RERG) and Ras-like 11 (RasL11)-like families
    smart00173
    Location:19167
    RAS; Ras subfamily of RAS small GTPases
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