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FAM86B1 family with sequence similarity 86 member B1 [ Homo sapiens (human) ]

Gene ID: 85002, updated on 13-May-2022

Summary

Official Symbol
FAM86B1provided by HGNC
Official Full Name
family with sequence similarity 86 member B1provided by HGNC
Primary source
HGNC:HGNC:28268
See related
Ensembl:ENSG00000186523 MIM:616122; AllianceGenome:HGNC:28268
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable methyltransferase activity. Predicted to be involved in methylation. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thyroid (RPKM 3.6), ovary (RPKM 3.6) and 25 other tissues See more
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Genomic context

See FAM86B1 in Genome Data Viewer
Location:
8p23.1
Exon count:
9
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (12182106..12194937, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (12703972..12715988, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (12039615..12051642, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 66 member D Neighboring gene defensin beta 109D (pseudogene) Neighboring gene family with sequence similarity 90 member A2, pseudogene Neighboring gene ALG1 like 11, pseudogene Neighboring gene family with sequence similarity 85 member A Neighboring gene ectonucleotide pyrophosphatase/phosphodiesterase 7 pseudogene 12 Neighboring gene defensin beta 131D (pseudogene)

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC16279, MGC104828

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in methylation IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
putative protein N-methyltransferase FAM86B1
Names
protein FAM86B1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001083537.4NP_001077006.1  putative protein N-methyltransferase FAM86B1

    See identical proteins and their annotated locations for NP_001077006.1

    Status: VALIDATED

    Source sequence(s)
    AC145124
    Consensus CDS
    CCDS59512.1
    UniProtKB/Swiss-Prot
    Q8N7N1
    UniProtKB/TrEMBL
    Q4KMP3
    Related
    ENSP00000407067.2, ENST00000448228.7
    Conserved Domains (2) summary
    pfam14904
    Location:680
    FAM86; Family of unknown function
    cl17173
    Location:101252
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

RNA

  1. NR_003494.3 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC145124
    Related
    ENST00000340537.9

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    12182106..12194937 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024447314.2XP_024303082.1  putative protein N-methyltransferase FAM86B1 isoform X7

    Conserved Domains (1) summary
    cl17173
    Location:84211
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  2. XM_047422358.1XP_047278314.1  putative protein N-methyltransferase FAM86B1 isoform X4

  3. XM_017013918.3XP_016869407.1  putative protein N-methyltransferase FAM86B1 isoform X6

  4. XM_006716260.5XP_006716323.1  putative protein N-methyltransferase FAM86B1 isoform X8

    Conserved Domains (1) summary
    cl17173
    Location:74225
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  5. XM_017013917.3XP_016869406.1  putative protein N-methyltransferase FAM86B1 isoform X5

  6. XM_006716257.5XP_006716320.1  putative protein N-methyltransferase FAM86B1 isoform X2

    Conserved Domains (2) summary
    pfam14904
    Location:670
    FAM86; Family of unknown function
    cl17173
    Location:108259
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  7. XM_047422359.1XP_047278315.1  putative protein N-methyltransferase FAM86B1 isoform X4

  8. XM_017013916.3XP_016869405.1  putative protein N-methyltransferase FAM86B1 isoform X3

  9. XM_006716256.5XP_006716319.1  putative protein N-methyltransferase FAM86B1 isoform X1

    UniProtKB/TrEMBL
    E9PN63
    Related
    ENSP00000432931.1, ENST00000533852.6
    Conserved Domains (2) summary
    pfam14904
    Location:697
    FAM86; Family of unknown function
    cl17173
    Location:135286
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  10. XM_024447315.2XP_024303083.1  putative protein N-methyltransferase FAM86B1 isoform X10

    Conserved Domains (1) summary
    cl17173
    Location:47174
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  11. XM_011543843.4XP_011542145.1  putative protein N-methyltransferase FAM86B1 isoform X9

    Conserved Domains (1) summary
    cl17173
    Location:35186
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  12. XM_047422356.1XP_047278312.1  putative protein N-methyltransferase FAM86B1 isoform X4

  13. XM_011543842.4XP_011542144.1  putative protein N-methyltransferase FAM86B1 isoform X7

    Conserved Domains (1) summary
    cl17173
    Location:84211
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  14. XM_047422362.1XP_047278318.1  putative protein N-methyltransferase FAM86B1 isoform X12

  15. XM_047422354.1XP_047278310.1  putative protein N-methyltransferase FAM86B1 isoform X4

  16. XM_024447313.2XP_024303081.1  putative protein N-methyltransferase FAM86B1 isoform X7

    Conserved Domains (1) summary
    cl17173
    Location:84211
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  17. XM_047422355.1XP_047278311.1  putative protein N-methyltransferase FAM86B1 isoform X4

  18. XM_047422357.1XP_047278313.1  putative protein N-methyltransferase FAM86B1 isoform X4

  19. XM_047422361.1XP_047278317.1  putative protein N-methyltransferase FAM86B1 isoform X11

    Related
    ENSP00000431362.1, ENST00000534520.5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    12703972..12715988 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)