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PPP1R16A protein phosphatase 1 regulatory subunit 16A [ Homo sapiens (human) ]

Gene ID: 84988, updated on 24-Nov-2020

Summary

Official Symbol
PPP1R16Aprovided by HGNC
Official Full Name
protein phosphatase 1 regulatory subunit 16Aprovided by HGNC
Primary source
HGNC:HGNC:14941
See related
Ensembl:ENSG00000160972 MIM:609172
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MYPT3
Summary
Myosin light chain kinase and phosphatase (MLCP) complexes control the phosphorylation states of regulatory myosin light chains, which is crucial for muscle and intracellular movement. MLCPs typically contain a catalytic protein phosphatase 1 (PP1c) subunit, a myosin phosphatase targeting (MYPT) subunit, and another smaller subunit. The protein encoded by this gene represents an MYPT subunit, which is responsible for directing PP1c to its intended targets. However, while the phosphorylation of other MYPT members results in PP1c inactivation, phosphorylation of the encoded protein by protein kinase A results in PP1c activation. [provided by RefSeq, Jan 2020]
Expression
Broad expression in duodenum (RPKM 18.4), small intestine (RPKM 14.8) and 25 other tissues See more
Orthologs

Genomic context

See PPP1R16A in Genome Data Viewer
Location:
8q24.3
Exon count:
15
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (144477982..144502121)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (145703365..145727504)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene cysteine and histidine rich 1 Neighboring gene microRNA 10400 Neighboring gene kinesin family member C2 Neighboring gene forkhead box H1 Neighboring gene uncharacterized LOC101928953 Neighboring gene glutamic--pyruvic transaminase Neighboring gene major facilitator superfamily domain containing 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Common genetic variants associated with cognitive performance identified using the proxy-phenotype method.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC14333

Gene Ontology Provided by GOA

Function Evidence Code Pubs
myosin phosphatase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein phosphatase 1 binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein phosphatase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
regulation of phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
regulation of protein dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
protein phosphatase 1 regulatory subunit 16A
Names
myosin phosphatase-targeting subunit 3
protein phosphatase 1, regulatory (inhibitor) subunit 16A

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001329442.2NP_001316371.1  protein phosphatase 1 regulatory subunit 16A

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All five variants encode the same protein.
    Source sequence(s)
    AC084125, BC053506, DB457525, HY013777, HY168641
    Consensus CDS
    CCDS6429.1
    UniProtKB/Swiss-Prot
    Q96I34
    Conserved Domains (3) summary
    cd00204
    Location:98285
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:75167
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:75101
    ANK; ANK repeat [structural motif]
  2. NM_001329443.2NP_001316372.1  protein phosphatase 1 regulatory subunit 16A

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All five variants encode the same protein.
    Source sequence(s)
    BC053506, CN301973, DB457525, HY168641
    Consensus CDS
    CCDS6429.1
    UniProtKB/Swiss-Prot
    Q96I34
    Related
    ENSP00000292539.4, ENST00000292539.8
    Conserved Domains (3) summary
    cd00204
    Location:98285
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:75167
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:75101
    ANK; ANK repeat [structural motif]
  3. NM_001329444.2NP_001316373.1  protein phosphatase 1 regulatory subunit 16A

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All five variants encode the same protein.
    Source sequence(s)
    BC053506, BM761618, HY168641, HY176205
    Consensus CDS
    CCDS6429.1
    UniProtKB/Swiss-Prot
    Q96I34
    Conserved Domains (3) summary
    cd00204
    Location:98285
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:75167
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:75101
    ANK; ANK repeat [structural motif]
  4. NM_001329445.2NP_001316374.1  protein phosphatase 1 regulatory subunit 16A

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. All five variants encode the same protein.
    Source sequence(s)
    BC053506, BM762557, HY168641
    Consensus CDS
    CCDS6429.1
    UniProtKB/Swiss-Prot
    Q96I34
    Conserved Domains (3) summary
    cd00204
    Location:98285
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:75167
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:75101
    ANK; ANK repeat [structural motif]
  5. NM_032902.7NP_116291.1  protein phosphatase 1 regulatory subunit 16A

    See identical proteins and their annotated locations for NP_116291.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All five variants encode the same protein.
    Source sequence(s)
    AC084125, BC053506, DB457525, HY050499, HY168641
    Consensus CDS
    CCDS6429.1
    UniProtKB/Swiss-Prot
    Q96I34
    Conserved Domains (3) summary
    cd00204
    Location:98285
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:75167
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:75101
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    144477982..144502121
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024447311.1XP_024303079.1  protein phosphatase 1 regulatory subunit 16A isoform X1

    Conserved Domains (2) summary
    cd00204
    Location:75187
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:75101
    ANK; ANK repeat [structural motif]
  2. XM_024447312.1XP_024303080.1  protein phosphatase 1 regulatory subunit 16A isoform X2

    Conserved Domains (2) summary
    cd00204
    Location:12124
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:1238
    ANK; ANK repeat [structural motif]
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