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RANBP3 RAN binding protein 3 [ Homo sapiens (human) ]

Gene ID: 8498, updated on 5-Dec-2018

Summary

Official Symbol
RANBP3provided by HGNC
Official Full Name
RAN binding protein 3provided by HGNC
Primary source
HGNC:HGNC:9850
See related
Ensembl:ENSG00000031823 MIM:603327
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a protein with a RanBD1 domain that is found in both the nucleus and cytoplasm. This protein plays a role in nuclear export as part of a heteromeric complex. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 18.0), lung (RPKM 13.0) and 25 other tissues See more
Orthologs

Genomic context

See RANBP3 in Genome Data Viewer
Location:
19p13.3
Exon count:
19
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (5916139..5978309, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (5916150..5978320, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene NADH:ubiquinone oxidoreductase subunit A11 Neighboring gene vimentin type intermediate filament associated coiled-coil protein Neighboring gene calcyphosine Neighboring gene uncharacterized LOC100128568 Neighboring gene regulatory factor X2 Neighboring gene ribosomal protein L32 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Canonical Wnt signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
    Canonical Wnt signaling pathway, organism-specific biosystem
    Canonical Wnt signaling pathway
  • HTLV-I infection, organism-specific biosystem (from KEGG)
    HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
  • HTLV-I infection, conserved biosystem (from KEGG)
    HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp586I1520

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
R-SMAD binding IPI
Inferred from Physical Interaction
more info
PubMed 
Ran GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
protein export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear pore IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
ran-binding protein 3
Names
epididymis secretory sperm binding protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001300865.1NP_001287794.1  ran-binding protein 3 isoform 4

    See identical proteins and their annotated locations for NP_001287794.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon and uses an alternate in-frame splice site in another exons, in the 5' coding region, compared to variant RANBP3-d. It encodes isoform 4, which is shorter than isoform RANBP3-d.
    Source sequence(s)
    AK025300, AK301942, AK314343, BM786367
    Consensus CDS
    CCDS74268.1
    UniProtKB/Swiss-Prot
    Q9H6Z4
    UniProtKB/TrEMBL
    B7Z7F3
    Related
    ENSP00000465085.1, ENST00000591092.5
    Conserved Domains (1) summary
    cd13180
    Location:320435
    RanBD_RanBP3; Ran-binding protein 3 Ran-binding domain
  2. NM_003624.2NP_003615.2  ran-binding protein 3 isoform RANBP3-a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (RANBP3-a) uses an alternate in-frame splice site in the 5' coding region, compared to variant RANBP3-d, resulting in a shorter protein (isoform RANBP3-a).
    Source sequence(s)
    AK025300, AK222990, BM786367, CB306615
    Consensus CDS
    CCDS45935.1
    UniProtKB/Swiss-Prot
    Q9H6Z4
    UniProtKB/TrEMBL
    Q53GE1
    Related
    ENSP00000404837.1, ENST00000439268.6
    Conserved Domains (1) summary
    cd13180
    Location:388503
    RanBD_RanBP3; Ran-binding protein 3 Ran-binding domain
  3. NM_007320.2NP_015559.2  ran-binding protein 3 isoform RANBP3-b

    See identical proteins and their annotated locations for NP_015559.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (RANBP3-b) lacks an alternate in-frame exon, compared to variant RANBP3-d, resulting in a shorter protein (isoform RANBP3-b), compared to isoform RANBP3-d.
    Source sequence(s)
    AK025300, AK314343, BM786367
    Consensus CDS
    CCDS42477.1
    UniProtKB/Swiss-Prot
    Q9H6Z4
    Related
    ENSP00000034275.7, ENST00000034275.12
    Conserved Domains (1) summary
    cd13180
    Location:325440
    RanBD_RanBP3; Ran-binding protein 3 Ran-binding domain
  4. NM_007322.3NP_015561.1  ran-binding protein 3 isoform RANBP3-d

    See identical proteins and their annotated locations for NP_015561.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (RANBP3-d) represents the longest transcript and encodes the longest isoform (RANBP3-d).
    Source sequence(s)
    AK025300, BM786367
    Consensus CDS
    CCDS42478.1
    UniProtKB/Swiss-Prot
    Q9H6Z4
    Related
    ENSP00000341483.5, ENST00000340578.10
    Conserved Domains (1) summary
    cd13180
    Location:393508
    RanBD_RanBP3; Ran-binding protein 3 Ran-binding domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p12 Primary Assembly

    Range
    5916139..5978309 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006722928.1XP_006722991.1  ran-binding protein 3 isoform X1

    See identical proteins and their annotated locations for XP_006722991.1

    Conserved Domains (1) summary
    cd13180
    Location:112227
    RanBD_RanBP3; Ran-binding protein 3 Ran-binding domain
  2. XM_006722929.1XP_006722992.1  ran-binding protein 3 isoform X1

    See identical proteins and their annotated locations for XP_006722992.1

    Conserved Domains (1) summary
    cd13180
    Location:112227
    RanBD_RanBP3; Ran-binding protein 3 Ran-binding domain
  3. XM_011528393.2XP_011526695.1  ran-binding protein 3 isoform X1

    See identical proteins and their annotated locations for XP_011526695.1

    Conserved Domains (1) summary
    cd13180
    Location:112227
    RanBD_RanBP3; Ran-binding protein 3 Ran-binding domain
  4. XM_011528392.1XP_011526694.1  ran-binding protein 3 isoform X1

    See identical proteins and their annotated locations for XP_011526694.1

    Conserved Domains (1) summary
    cd13180
    Location:112227
    RanBD_RanBP3; Ran-binding protein 3 Ran-binding domain
  5. XM_011528394.1XP_011526696.1  ran-binding protein 3 isoform X1

    See identical proteins and their annotated locations for XP_011526696.1

    Conserved Domains (1) summary
    cd13180
    Location:112227
    RanBD_RanBP3; Ran-binding protein 3 Ran-binding domain
  6. XM_024451749.1XP_024307517.1  ran-binding protein 3 isoform X1

    Conserved Domains (1) summary
    cd13180
    Location:112227
    RanBD_RanBP3; Ran-binding protein 3 Ran-binding domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_007321.1: Suppressed sequence

    Description
    NM_007321.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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