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FIBCD1 fibrinogen C domain containing 1 [ Homo sapiens (human) ]

Gene ID: 84929, updated on 22-Sep-2022

Summary

Official Symbol
FIBCD1provided by HGNC
Official Full Name
fibrinogen C domain containing 1provided by HGNC
Primary source
HGNC:HGNC:25922
See related
Ensembl:ENSG00000130720 MIM:613357; AllianceGenome:HGNC:25922
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
FIBCD1 is a conserved type II transmembrane endocytic receptor that binds chitin and is located primarily in the intestinal brush border (Schlosser et al., 2009 [PubMed 19710473]).[supplied by OMIM, Apr 2010]
Expression
Biased expression in testis (RPKM 2.4), adrenal (RPKM 1.6) and 6 other tissues See more
Orthologs
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Genomic context

See FIBCD1 in Genome Data Viewer
Location:
9q34.12
Exon count:
10
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (130902440..130940709, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (143107312..143144126, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (133777827..133814634, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 3771 Neighboring gene pyroglutamylated RFamide peptide Neighboring gene Sharpr-MPRA regulatory region 15615 Neighboring gene FIBCD1 antisense RNA 1 Neighboring gene small nucleolar RNA SNORA31 Neighboring gene laminin subunit gamma 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ14810

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables chitin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in collagen-containing extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
fibrinogen C domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145106.2NP_001138578.1  fibrinogen C domain-containing protein 1

    See identical proteins and their annotated locations for NP_001138578.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL161733, BC032953, DC404353
    Consensus CDS
    CCDS6937.1
    UniProtKB/Swiss-Prot
    Q8N539, Q96SJ7
    Related
    ENSP00000414501.1, ENST00000448616.5
    Conserved Domains (1) summary
    cd00087
    Location:241457
    FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
  2. NM_032843.5NP_116232.3  fibrinogen C domain-containing protein 1

    See identical proteins and their annotated locations for NP_116232.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript.
    Source sequence(s)
    AL161733, BC032953
    Consensus CDS
    CCDS6937.1
    UniProtKB/Swiss-Prot
    Q8N539, Q96SJ7
    Related
    ENSP00000361413.4, ENST00000372338.9
    Conserved Domains (1) summary
    cd00087
    Location:241457
    FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    130902440..130940709 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047423989.1XP_047279945.1  fibrinogen C domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q96SJ7
  2. XM_047423990.1XP_047279946.1  fibrinogen C domain-containing protein 1 isoform X2

    UniProtKB/TrEMBL
    A3KFJ8
    Related
    ENSP00000361412.1, ENST00000372337.6

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    143107312..143144126 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)