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FIBCD1 fibrinogen C domain containing 1 [ Homo sapiens (human) ]

Gene ID: 84929, updated on 19-Feb-2024

Summary

Official Symbol
FIBCD1provided by HGNC
Official Full Name
fibrinogen C domain containing 1provided by HGNC
Primary source
HGNC:HGNC:25922
See related
Ensembl:ENSG00000130720 MIM:613357; AllianceGenome:HGNC:25922
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
FIBCD1 is a conserved type II transmembrane endocytic receptor that binds chitin and is located primarily in the intestinal brush border (Schlosser et al., 2009 [PubMed 19710473]).[supplied by OMIM, Apr 2010]
Expression
Biased expression in testis (RPKM 2.4), adrenal (RPKM 1.6) and 6 other tissues See more
Orthologs
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Genomic context

See FIBCD1 in Genome Data Viewer
Location:
9q34.12
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (130902440..130940709, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (143107312..143145777, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (133777827..133814634, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene ABL breakpoint recombination region Neighboring gene ABL proto-oncogene 1, non-receptor tyrosine kinase Neighboring gene uncharacterized LOC124902287 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:133709696-133710222 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:133710223-133710748 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20408 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr9:133722835-133723457 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:133735115-133735964 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:133735965-133736812 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:133737874-133738374 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:133738375-133738875 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr9:133741863-133742364 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29164 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr9:133756258-133757457 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:133759146-133759916 Neighboring gene Sharpr-MPRA regulatory region 3771 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:133769017-133769531 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:133770320-133771007 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:133771008-133771694 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:133789692-133790384 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:133794286-133794826 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:133796861-133797810 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:133798030-133798213 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:133798761-133799708 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29165 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:133805119-133805663 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29166 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29167 Neighboring gene pyroglutamylated RFamide peptide Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:133814336-133815266 Neighboring gene Sharpr-MPRA regulatory region 15615 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:133818700-133818873 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:133822337-133822542 Neighboring gene FIBCD1 antisense RNA 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:133835976-133836150 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr9:133837863-133838450 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr9:133838451-133839037 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:133856871-133857391 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:133861291-133862162 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:133870475-133871031 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20410 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29169 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:133887620-133888188 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:133888189-133888756 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:133888757-133889324 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:133892018-133892589 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:133894433-133894620 Neighboring gene uncharacterized LOC124900284 Neighboring gene laminin subunit gamma 3 Neighboring gene LAMC3 intron enhancer-blocking element 9-5 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:133925447-133925947 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr9:133927058-133928257 Neighboring gene LAMC3 intron enhancer-blocking element 9-2 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:133933565-133934066 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:133944345-133944854 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:133954421-133954984 Neighboring gene uncharacterized LOC124902289 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:133967720-133968318 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:133968319-133968915

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ14810

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables chitin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in collagen-containing extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
fibrinogen C domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145106.2NP_001138578.1  fibrinogen C domain-containing protein 1

    See identical proteins and their annotated locations for NP_001138578.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL161733, BC032953, DC404353
    Consensus CDS
    CCDS6937.1
    UniProtKB/Swiss-Prot
    A3KFK0, Q6UXK6, Q8N539, Q96SJ7
    UniProtKB/TrEMBL
    A8K8X4
    Related
    ENSP00000414501.1, ENST00000448616.5
    Conserved Domains (1) summary
    cd00087
    Location:241457
    FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
  2. NM_032843.5NP_116232.3  fibrinogen C domain-containing protein 1

    See identical proteins and their annotated locations for NP_116232.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript.
    Source sequence(s)
    AL161733, BC032953
    Consensus CDS
    CCDS6937.1
    UniProtKB/Swiss-Prot
    A3KFK0, Q6UXK6, Q8N539, Q96SJ7
    UniProtKB/TrEMBL
    A8K8X4
    Related
    ENSP00000361413.4, ENST00000372338.9
    Conserved Domains (1) summary
    cd00087
    Location:241457
    FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    130902440..130940709 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047423989.1XP_047279945.1  fibrinogen C domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A3KFK0, Q6UXK6, Q8N539, Q96SJ7
    UniProtKB/TrEMBL
    A8K8X4
  2. XM_047423990.1XP_047279946.1  fibrinogen C domain-containing protein 1 isoform X2

    UniProtKB/TrEMBL
    A3KFJ8
    Related
    ENSP00000361412.1, ENST00000372337.6

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    143107312..143145777 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054364052.1XP_054220027.1  fibrinogen C domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A3KFK0, Q6UXK6, Q8N539, Q96SJ7
    UniProtKB/TrEMBL
    A8K8X4
  2. XM_054364053.1XP_054220028.1  fibrinogen C domain-containing protein 1 isoform X2

    UniProtKB/TrEMBL
    A3KFJ8