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POMGNT2 protein O-linked mannose N-acetylglucosaminyltransferase 2 (beta 1,4-) [ Homo sapiens (human) ]

Gene ID: 84892, updated on 3-Jun-2018
Official Symbol
POMGNT2provided by HGNC
Official Full Name
protein O-linked mannose N-acetylglucosaminyltransferase 2 (beta 1,4-)provided by HGNC
Primary source
HGNC:HGNC:25902
See related
Ensembl:ENSG00000144647 MIM:614828; Vega:OTTHUMG00000133038
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AGO61; GTDC2; MDDGA8; C3orf39
Summary
This gene encodes a protein with glycosyltransferase activity although its function is not currently known. [provided by RefSeq, Sep 2012]
Expression
Ubiquitous expression in endometrium (RPKM 11.1), brain (RPKM 9.1) and 25 other tissues See more
Orthologs
See POMGNT2 in Genome Data Viewer
Location:
3p22.1
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 3 NC_000003.12 (43079229..43106085, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (43120721..43147575, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene KRBOX1 antisense RNA 1 Neighboring gene KRAB box domain containing 1 Neighboring gene family with sequence similarity 198 member A Neighboring gene uncharacterized LOC107986079 Neighboring gene uncharacterized LOC105377051 Neighboring gene Sharpr-MPRA regulatory regions 3209 and 6245

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Mannose type O-glycan biosynthesis, organism-specific biosystem (from KEGG)
    Mannose type O-glycan biosynthesis, organism-specific biosystemBiosynthesis of mammalian O-mannosyl glycans is initiated by the transfer of mannose from mannose-P-Dol to serine or threonine residue, followed by extensions with N-acetylglucosamine (GlcNAc) and ga...
  • Mannose type O-glycan biosynthesis, conserved biosystem (from KEGG)
    Mannose type O-glycan biosynthesis, conserved biosystemBiosynthesis of mammalian O-mannosyl glycans is initiated by the transfer of mannose from mannose-P-Dol to serine or threonine residue, followed by extensions with N-acetylglucosamine (GlcNAc) and ga...
  • Metabolic pathways, organism-specific biosystem (from KEGG)
    Metabolic pathways, organism-specific biosystem
    Metabolic pathways
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • O-linked glycosylation, organism-specific biosystem (from REACTOME)
    O-linked glycosylation, organism-specific biosystemO-glycosylation is an important post-translational modification (PTM) required for correct functioning of many proteins (Van den Steen et al. 1998, Moremen et al. 2012). The O-glycosylation of protei...
  • Post-translational protein modification, organism-specific biosystem (from REACTOME)
    Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ14566

Gene Ontology Provided by GOA

Function Evidence Code Pubs
acetylglucosaminyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
acetylglucosaminyltransferase activity TAS
Traceable Author Statement
more info
 
protein O-GlcNAc transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
neuron migration ISS
Inferred from Sequence or Structural Similarity
more info
 
protein O-linked glycosylation IDA
Inferred from Direct Assay
more info
PubMed 
protein O-linked glycosylation TAS
Traceable Author Statement
more info
 
protein O-linked mannosylation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2
Names
glycosyltransferase-like domain containing 2
glycosyltransferase-like domain-containing protein 2
NP_116195.2
XP_005265572.1
XP_011532465.1
XP_016862842.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032930.1 RefSeqGene

    Range
    5001..31855
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_032806.5NP_116195.2  protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2 precursor

    See identical proteins and their annotated locations for NP_116195.2

    Status: VALIDATED

    Source sequence(s)
    AC092042, BC060861
    Consensus CDS
    CCDS2709.1
    UniProtKB/Swiss-Prot
    Q8NAT1
    UniProtKB/TrEMBL
    A0A024R2P4
    Related
    ENSP00000344125.2, OTTHUMP00000164032, ENST00000344697.2, OTTHUMT00000256643
    Conserved Domains (2) summary
    cd00063
    Location:493580
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam04577
    Location:264395
    DUF563; Protein of unknown function (DUF563)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p12 Primary Assembly

    Range
    43079229..43106085 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011534163.2XP_011532465.1  protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2 isoform X1

    See identical proteins and their annotated locations for XP_011532465.1

    UniProtKB/Swiss-Prot
    Q8NAT1
    UniProtKB/TrEMBL
    A0A024R2P4
    Conserved Domains (2) summary
    cd00063
    Location:493580
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam04577
    Location:264395
    DUF563; Protein of unknown function (DUF563)
  2. XM_017007353.1XP_016862842.1  protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2 isoform X1

    UniProtKB/Swiss-Prot
    Q8NAT1
    UniProtKB/TrEMBL
    A0A024R2P4
    Conserved Domains (2) summary
    cd00063
    Location:493580
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam04577
    Location:264395
    DUF563; Protein of unknown function (DUF563)
  3. XM_005265515.3XP_005265572.1  protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2 isoform X1

    See identical proteins and their annotated locations for XP_005265572.1

    UniProtKB/Swiss-Prot
    Q8NAT1
    UniProtKB/TrEMBL
    A0A024R2P4
    Related
    ENSP00000408992.1, OTTHUMP00000209937, ENST00000441964.1
    Conserved Domains (2) summary
    cd00063
    Location:493580
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam04577
    Location:264395
    DUF563; Protein of unknown function (DUF563)
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