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MIR503HG MIR503 host gene [ Homo sapiens (human) ]

Gene ID: 84848, updated on 17-Sep-2024

Summary

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Official Symbol
MIR503HGprovided by HGNC
Official Full Name
MIR503 host geneprovided by HGNC
Primary source
HGNC:HGNC:28258
See related
AllianceGenome:HGNC:28258
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
H19X; MIR503HG2
Expression
Biased expression in placenta (RPKM 36.8), ovary (RPKM 11.9) and 3 other tissues See more
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Genomic context

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See MIR503HG in Genome Data Viewer
Location:
Xq26.3
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (134543377..134546630, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (132868562..132871818, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (133677407..133680660, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21011 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21012 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:133684089-133684718 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:133684719-133685347 Neighboring gene microRNA 450a-2 Neighboring gene long intergenic non-protein coding RNA 629 Neighboring gene microRNA 542 Neighboring gene microRNA 503 Neighboring gene microRNA 424 Neighboring gene placenta enriched 1 Neighboring gene MED14-independent group 3 enhancer GRCh37_chrX:133737986-133739185 Neighboring gene ribosomal protein L21 pseudogene 133

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. lncRNA MIR503HG functioned as a tumor suppressor and inhibited cell proliferation, metastasis and epithelial-mesenchymal transition in bladder cancer. Qiu F, et al. J Cell Biochem, 2019 Jun. PMID 30672010
  2. The Increased lncRNA MIR503HG in Preeclampsia Modulated Trophoblast Cell Proliferation, Invasion, and Migration via Regulating Matrix Metalloproteinases and NF-κB Signaling. Cheng D, et al. Dis Markers, 2019. PMID 31467616, Free PMC Article
  3. Structure and expression of the long noncoding RNA gene MIR503 in humans and non-human primates. Choudhari R, et al. Mol Cell Endocrinol, 2020 Jun 15. PMID 32311422
  4. LncRNA MIR503HG inhibits cell migration and invasion via miR-103/OLFM4 axis in triple negative breast cancer. Fu J, et al. J Cell Mol Med, 2019 Jul. PMID 31062436, Free PMC Article
  5. Long non-coding RNA MIR503HG inhibits the proliferation, migration and invasion of colon cancer cells via miR-107/Par4 axis. Han H, et al. Exp Cell Res, 2020 Oct 15. PMID 32738347

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LINC MIR503HG Controls SC-beta Cell Differentiation and Insulin Production by Targeting CDH1 and HES1.
    Title: LINC MIR503HG Controls SC-β Cell Differentiation and Insulin Production by Targeting CDH1 and HES1.
  2. Loss of MIR503HG facilitates papillary renal cell carcinoma associated lymphatic metastasis by triggering NOTCH1/VEGFC signaling.
    Title: Loss of MIR503HG facilitates papillary renal cell carcinoma associated lymphatic metastasis by triggering NOTCH1/VEGFC signaling.
  3. lncRNA MIR503HG Targets miR-191-5p/PLCD1 Axis and Negatively Modulates Apoptosis, Extracellular Matrix Disruption, and Inflammation in Abdominal Aortic Aneurysm.
    Title: lncRNA MIR503HG Targets miR-191-5p/PLCD1 Axis and Negatively Modulates Apoptosis, Extracellular Matrix Disruption, and Inflammation in Abdominal Aortic Aneurysm.
  4. MIR503HG: A potential diagnostic and therapeutic target in human diseases.
    Title: MIR503HG: A potential diagnostic and therapeutic target in human diseases.
  5. [MIR503HG promotes esophageal squamous cell carcinoma cell proliferation, invasion and migration via hsa-miR-503 pathway].
    Title: [MIR503HG promotes esophageal squamous cell carcinoma cell proliferation, invasion and migration via hsa-miR-503 pathway].
  6. MIR503HG impeded ovarian cancer progression by interacting with SPI1 and preventing TMEFF1 transcription.
    Title: MIR503HG impeded ovarian cancer progression by interacting with SPI1 and preventing TMEFF1 transcription.
  7. Neutrophil Extracellular Traps (NETs) Promote Non-Small Cell Lung Cancer Metastasis by Suppressing lncRNA MIR503HG to Activate the NF-kappaB/NLRP3 Inflammasome Pathway.
    Title: Neutrophil Extracellular Traps (NETs) Promote Non-Small Cell Lung Cancer Metastasis by Suppressing lncRNA MIR503HG to Activate the NF-κB/NLRP3 Inflammasome Pathway.
  8. Identification of crucial noncoding RNAs and mRNAs in hypertrophic scars via RNA sequencing.
    Title: Identification of crucial noncoding RNAs and mRNAs in hypertrophic scars via RNA sequencing.
  9. LncRNA MIR503HG promotes hypertrophic scar progression via miR-143-3p-mediated Smad3 expression.
    Title: LncRNA MIR503HG promotes hypertrophic scar progression via miR-143-3p-mediated Smad3 expression.
  10. MIR503HG Loss Promotes Endothelial-to-Mesenchymal Transition in Vascular Disease.
    Title: MIR503HG Loss Promotes Endothelial-to-Mesenchymal Transition in Vascular Disease.
Submit: New GeneRIF Correction See all GeneRIFs (22)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Markers

Other Names

  • H19 X-linked co-expressed lncRNA
  • MIR503 host gene (non-protein coding)

Clone Names

  • MGC16121, AC004383.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_024607.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AW378319, BX090522, CN297454

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    134543377..134546630 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    132868562..132871818 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_032762.2: Suppressed sequence

    Description
    NM_032762.2: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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