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ACCS 1-aminocyclopropane-1-carboxylate synthase homolog (inactive) [ Homo sapiens (human) ]

Gene ID: 84680, updated on 25-Jan-2022

Summary

Official Symbol
ACCSprovided by HGNC
Official Full Name
1-aminocyclopropane-1-carboxylate synthase homolog (inactive)provided by HGNC
Primary source
HGNC:HGNC:23989
See related
Ensembl:ENSG00000110455 MIM:608405; AllianceGenome:HGNC:23989
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ACS; PHACS
Summary
Enables identical protein binding activity. Predicted to be involved in biosynthetic process. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Ubiquitous expression in spleen (RPKM 11.2), gall bladder (RPKM 7.3) and 25 other tissues See more
Orthologs
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Genomic context

See ACCS in Genome Data Viewer
Location:
11p11.2
Exon count:
20
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (44066118..44084237)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (44087820..44105787)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene chromosome 11 open reading frame 96 Neighboring gene 1-aminocyclopropane-1-carboxylate synthase homolog (inactive) like Neighboring gene exostosin glycosyltransferase 2 Neighboring gene VISTA enhancer hs2090 Neighboring gene ALX homeobox 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NOT enables 1-aminocyclopropane-1-carboxylate synthase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables pyridoxal phosphate binding NAS
Non-traceable Author Statement
more info
PubMed 
enables transaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular amino acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
1-aminocyclopropane-1-carboxylate synthase-like protein 1
Names
ACC synthase-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001127219.2NP_001120691.1  1-aminocyclopropane-1-carboxylate synthase-like protein 1

    See identical proteins and their annotated locations for NP_001120691.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses a different splice site in its 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC134775, BC020197, DA196370
    Consensus CDS
    CCDS7907.1
    UniProtKB/Swiss-Prot
    Q96QU6
    UniProtKB/TrEMBL
    A0A0S2Z622
    Conserved Domains (2) summary
    cd00609
    Location:99476
    AAT_like; Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine ...
    PLN02450
    Location:53499
    PLN02450; 1-aminocyclopropane-1-carboxylate synthase
  2. NM_032592.4NP_115981.1  1-aminocyclopropane-1-carboxylate synthase-like protein 1

    See identical proteins and their annotated locations for NP_115981.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC134775, BC020197, DA406116, DC390076
    Consensus CDS
    CCDS7907.1
    UniProtKB/Swiss-Prot
    Q96QU6
    UniProtKB/TrEMBL
    A0A0S2Z622
    Related
    ENSP00000263776.8, ENST00000263776.9
    Conserved Domains (2) summary
    cd00609
    Location:99476
    AAT_like; Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine ...
    PLN02450
    Location:53499
    PLN02450; 1-aminocyclopropane-1-carboxylate synthase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    44066118..44084237
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024448723.1XP_024304491.1  1-aminocyclopropane-1-carboxylate synthase-like protein 1 isoform X8

    Conserved Domains (1) summary
    cl27741
    Location:2264
    Aminotran_1_2; Aminotransferase class I and II
  2. XM_011520410.2XP_011518712.1  1-aminocyclopropane-1-carboxylate synthase-like protein 1 isoform X8

    See identical proteins and their annotated locations for XP_011518712.1

    Conserved Domains (1) summary
    cl27741
    Location:2264
    Aminotran_1_2; Aminotransferase class I and II
  3. XM_024448719.1XP_024304487.1  1-aminocyclopropane-1-carboxylate synthase-like protein 1 isoform X3

    Conserved Domains (1) summary
    PLN02450
    Location:53417
    PLN02450; 1-aminocyclopropane-1-carboxylate synthase
  4. XM_024448718.1XP_024304486.1  1-aminocyclopropane-1-carboxylate synthase-like protein 1 isoform X3

    Conserved Domains (1) summary
    PLN02450
    Location:53417
    PLN02450; 1-aminocyclopropane-1-carboxylate synthase
  5. XM_024448720.1XP_024304488.1  1-aminocyclopropane-1-carboxylate synthase-like protein 1 isoform X4

    Conserved Domains (1) summary
    cd00609
    Location:6355
    AAT_like; Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine ...
  6. XM_024448721.1XP_024304489.1  1-aminocyclopropane-1-carboxylate synthase-like protein 1 isoform X6

    Conserved Domains (1) summary
    cl27741
    Location:45317
    Aminotran_1_2; Aminotransferase class I and II
  7. XM_017018421.1XP_016873910.1  1-aminocyclopropane-1-carboxylate synthase-like protein 1 isoform X7

  8. XM_011520406.2XP_011518708.1  1-aminocyclopropane-1-carboxylate synthase-like protein 1 isoform X2

    Conserved Domains (1) summary
    cd00609
    Location:200520
    AAT_like; Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine ...
  9. XM_005253170.3XP_005253227.2  1-aminocyclopropane-1-carboxylate synthase-like protein 1 isoform X1

    Conserved Domains (1) summary
    PLN02450
    Location:154600
    PLN02450; 1-aminocyclopropane-1-carboxylate synthase
  10. XM_011520407.1XP_011518709.1  1-aminocyclopropane-1-carboxylate synthase-like protein 1 isoform X4

    Conserved Domains (1) summary
    cd00609
    Location:6355
    AAT_like; Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine ...
  11. XM_006718348.2XP_006718411.1  1-aminocyclopropane-1-carboxylate synthase-like protein 1 isoform X6

    See identical proteins and their annotated locations for XP_006718411.1

    Conserved Domains (1) summary
    cl27741
    Location:45317
    Aminotran_1_2; Aminotransferase class I and II
  12. XM_005253172.2XP_005253229.1  1-aminocyclopropane-1-carboxylate synthase-like protein 1 isoform X5

    Conserved Domains (1) summary
    cd00609
    Location:9346
    AAT_like; Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine ...

RNA

  1. XR_001748009.1 RNA Sequence

  2. XR_001748010.1 RNA Sequence

  3. XR_001748004.1 RNA Sequence

  4. XR_001748003.1 RNA Sequence

  5. XR_001748006.1 RNA Sequence

  6. XR_001748007.1 RNA Sequence

  7. XR_930915.2 RNA Sequence

  8. XR_001748005.1 RNA Sequence

  9. XR_001748008.2 RNA Sequence

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