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SPINK7 serine peptidase inhibitor Kazal type 7 [ Homo sapiens (human) ]

Gene ID: 84651, updated on 5-Aug-2022

Summary

Official Symbol
SPINK7provided by HGNC
Official Full Name
serine peptidase inhibitor Kazal type 7provided by HGNC
Primary source
HGNC:HGNC:24643
See related
Ensembl:ENSG00000145879 MIM:617288; AllianceGenome:HGNC:24643
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ECG2; ECRG2
Summary
Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of endopeptidase activity. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward esophagus (RPKM 102.7) See more
Orthologs
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Genomic context

See SPINK7 in Genome Data Viewer
Location:
5q32
Exon count:
4
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (148312423..148315919)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (148846934..148850430)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (147691986..147695482)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene FBXO38 divergent transcript Neighboring gene serine peptidase inhibitor Kazal type 13 Neighboring gene piggyBac transposable element derived 4 pseudogene 3 Neighboring gene serine peptidase inhibitor Kazal type 9 Neighboring gene F-box protein 38 Neighboring gene PRELI domain containing 3B pseudogene 9

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC133105, MGC133106

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cytokine production involved in inflammatory response IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
serine protease inhibitor Kazal-type 7
Names
ECRG-2
esophagus cancer-related gene 2 protein
esophagus cancer-related gene-2
serine peptidase inhibitor, Kazal type 7 (putative)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032566.3NP_115955.1  serine protease inhibitor Kazal-type 7 precursor

    See identical proteins and their annotated locations for NP_115955.1

    Status: VALIDATED

    Source sequence(s)
    AC091948, AF268198, AY359072
    Consensus CDS
    CCDS4289.1
    UniProtKB/Swiss-Prot
    P58062, Q32LY0
    Related
    ENSP00000274565.4, ENST00000274565.5
    Conserved Domains (1) summary
    cd01327
    Location:4185
    KAZAL_PSTI; Kazal-type pancreatic secretory trypsin inhibitors (PSTI) and related proteins, including the second domain of the ovomucoid turkey inhibitor and the C-terminal domain of the esophagus cancer-related gene-2 protein (ECRG-2), are members of the ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    148312423..148315919
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    148846934..148850430
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)