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USP38 ubiquitin specific peptidase 38 [ Homo sapiens (human) ]

Gene ID: 84640, updated on 21-Dec-2019

Summary

Official Symbol
USP38provided by HGNC
Official Full Name
ubiquitin specific peptidase 38provided by HGNC
Primary source
HGNC:HGNC:20067
See related
Ensembl:ENSG00000170185 MIM:618322
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HP43.8KD
Expression
Ubiquitous expression in bone marrow (RPKM 7.3), colon (RPKM 5.9) and 25 other tissues See more
Orthologs

Genomic context

See USP38 in Genome Data Viewer
Location:
4q31.21
Exon count:
11
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (143184917..143224429)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (144106070..144143141)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 2118 Neighboring gene uncharacterized LOC105377623 Neighboring gene microRNA 3139 Neighboring gene GRB2 associated binding protein 1 Neighboring gene ribosomal protein S2 pseudogene 20

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ35970, KIAA1891

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cysteine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
thiol-dependent ubiquitin-specific protease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
thiol-dependent ubiquitin-specific protease activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
protein deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein deubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ubiquitin carboxyl-terminal hydrolase 38
Names
deubiquitinating enzyme 38
ubiquitin specific protease 38
ubiquitin thioesterase 38
ubiquitin thiolesterase 38
ubiquitin-specific-processing protease 38
NP_001277254.1
NP_001277255.1
NP_115946.2
XP_011530662.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290325.1NP_001277254.1  ubiquitin carboxyl-terminal hydrolase 38 isoform 2

    See identical proteins and their annotated locations for NP_001277254.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains a 3' terminal exon that extends past a splice site used in variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC099549, BC039115
    Consensus CDS
    CCDS77964.1
    UniProtKB/Swiss-Prot
    Q8NB14
    Related
    ENSP00000427647.1, ENST00000510377.5
    Conserved Domains (2) summary
    cd02664
    Location:446947
    Peptidase_C19H; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam00443
    Location:445946
    UCH; Ubiquitin carboxyl-terminal hydrolase
  2. NM_001290326.1NP_001277255.1  ubiquitin carboxyl-terminal hydrolase 38 isoform 3

    See identical proteins and their annotated locations for NP_001277255.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 3, which is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AC099549, AK057992, AK093289, AK093754, BC039115
    UniProtKB/Swiss-Prot
    Q8NB14
    UniProtKB/TrEMBL
    B3KSB9
    Conserved Domains (2) summary
    cd02664
    Location:1492
    Peptidase_C19H; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam00443
    Location:1491
    UCH; Ubiquitin carboxyl-terminal hydrolase
  3. NM_032557.6NP_115946.2  ubiquitin carboxyl-terminal hydrolase 38 isoform 1

    See identical proteins and their annotated locations for NP_115946.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC099549, AK091712, BC039115, BG575871
    Consensus CDS
    CCDS3758.1
    UniProtKB/Swiss-Prot
    Q8NB14
    Related
    ENSP00000303434.4, ENST00000307017.9
    Conserved Domains (1) summary
    cd02664
    Location:446947
    Peptidase_C19H; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    143184917..143224429
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011532360.3XP_011530662.1  ubiquitin carboxyl-terminal hydrolase 38 isoform X1

    Conserved Domains (2) summary
    cd02664
    Location:412913
    Peptidase_C19H; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam00443
    Location:411912
    UCH; Ubiquitin carboxyl-terminal hydrolase
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